A specific structural alteration in the heparan sulphate of human glomerular basement membrane in diabetes

Diabetologia

Volumn 43, Issue 8, 2000, Pages 1056-1059

  Edge, A S B ^a   Spiro, R G ^a  

^a JOSLIN DIABETES CENTER   (United States)

Author keywords

3 O Sulphated glucosamine; Diabetic glomerular basement membrane alterations; Glomerular anionic filter; Glomerular basement membrane; Heparan sulphate binding; Heparan sulphate sulphation sites; Hydrazine nitrous acid fragmentation; Iduronic acid

Indexed keywords

ANTITHROMBIN; GLUCOSAMINE DERIVATIVE; HEPARAN SULFATE; HYDRAZINE; IDURONIC ACID; NITROUS ACID; SULFOTRANSFERASE;

ADULT; AGED; ARTICLE; CADAVER; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENZYME ACTIVITY; GLOMERULUS BASEMENT MEMBRANE; HUMAN; HUMAN TISSUE; PATHOGENESIS; PRIORITY JOURNAL; SULFATION;

AGED; AGED, 80 AND OVER; AUTOPSY; BASEMENT MEMBRANE; DIABETES MELLITUS; DISACCHARIDES; HEPARAN SULFATE PROTEOGLYCANS; HEPARITIN SULFATE; HUMANS; KIDNEY GLOMERULUS; MIDDLE AGED; REFERENCE VALUES;

EID: 0033838261     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051489     Document Type: Article

References (10)

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4. Studies on the macromolecular components of human glomerular basement membrane and alterations in diabetes. Decreased levels of heparan sulphate proteoglycan and laminin
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7. Regulated diversity of heparan sulfate
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9. Evaluation of the cell specificity and sulfate dependence of glomerular extracellular matrix proteoglycan synthesis
10. A novel role for 3-O-sulphated heparan sulphate in herpes simplex virus 1 entry