Bypassing the kinetic trap of serpin protein folding by loop extension

Protein Science

Volumn 9, Issue 8, 2000, Pages 1497-1502

  Im, Hana ^a   Ahn, Hee Young ^a   Yu, Myeong Hee ^a  

^a Korea Institute of Science and Technology   (South Korea)

Author keywords

Kinetic trap; Loop extension; Polypeptide connectivity; Protein folding; 1 antitrypsin

Indexed keywords

ALPHA 1 ANTITRYPSIN; SERINE PROTEINASE INHIBITOR; VIRUS ENVELOPE PROTEIN;

ARTICLE; CHEMICAL BOND; CONFORMATIONAL TRANSITION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE;

EID: 0033837714     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.9.8.1497     Document Type: Article

References (34)

1. Principles that govern the folding of protein chains
2. Metastable states and folding free energy barriers
3. Influenza hemagglutinin: Kinetic control of protein function
4. Plasma serine proteinase inhibitors (serpins) exhibit major conformational changes and a large increase in conformational stability upon cleavage at their reactive sites
5. Influenza hemagglutinin is spring-loaded by a metastable native conformation
6. A spring-loaded mechanism for the conformational change of influenza hemagglutinin
7. Mobile reactive centre of serpins and the control of thrombosis
8. Core structure of gp41 from the HIV envelope glycoprotein
9. Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation
10. Protein folding. Up the kinetic pathway
11. The prosegment-subtilisin BPN' complex: Crystal structure of a specific 'foldase'
12. Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants
13. 1-antitrypsin for structure and function of serpins
14. 1-antitrypsin
15. 1-antitrypsin that confer enhancement in thermal stability
16. The serpin-proteinase complex revealed
17. Purification of active human plasminogen activator inhibitor-1 from Escherichia coli. Comparison with natural and recombinant forms purified from eucaryotic cells
18. 1-antitrypsin
19. 1-antitrypsin. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function
20. 1-antitrypsin
21. 1-protease inhibitor probed by limited proteolysis
22. Structural basis of latency in plasminogen activator inhibitor-1
23. A peptide model of a protein folding intermediate
24. Regulation of Drosophila heat shock factor trimerization: Global sequence requirements and independence of nuclear localization
25. Measuring the conformational stability of a protein
26. Significance of secondary structure predictions on the reactive center loop region of serpins: A model for the folding of serpins into a metastable state
27. Evidence for a molten globule state as a general intermediate in protein folding
28. 1- antitrypsin at 2.7 Å
29. Structure of α-lytic protease complexed with its pro region
30. Role of a subdomain in the folding of bovine pancreatic trypsin inhibitor
31. What do dysfunctional serpins tell us about molecular mobility and disease?
32. Kinetically controlled folding of the serpin plasminogen activator inhibitor I
33. Reexamination of the folding of BPTI: Predominance of native intermediates
34. The structure and function of the hemagglutinin membrane glycoprotein of influenza virus