Identification of an amino acid sequence motif in the cytoplasmic domain of the NCAM-140 kDa isoform essential for its neuritogenic activity

Journal of Neurochemistry

Volumn 75, Issue 3, 2000, Pages 1274-1282

  Kolkova, Kateryna ^a   Pedersen, Nina ^a   Berezin, Vladimir ^a   Bock, Elisabeth ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Cytoplasmic domain; Fibroblasts; NCAM; Neurite outgrowth

Indexed keywords

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

EID: 0033836365     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.751274.x     Document Type: Article

References (46)

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7. 2+ channels
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14. Functional characterization of NCAM fibronectin type III domains: Demonstration of modulatory effects of the proline-rich sequence encoded by alternatively spliced exons a and AAG
15. The first immunoglobulin-like neural cell adhesion molecule (NCAM) domain is involved in double-reciprocal interaction with the second immunoglobulin-like NCAM domain and in heparin binding
16. NCAM-stimulated neurite outgrowth depends on activation of protein kinase C and the Ras-mitogen activated protein kinase pathway
17. Phenotypic properties of neoplastic cell lines developed from fetal rat brain cells in culture after exposure to ethylnitrosourea in vivo
18. VASE-encoded peptide modifies NCAM and L1-mediated neurite outgrowth
19. Expression of the cell adhesion molecules N-CAM and L1 in B16 melanoma cells
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21. Alternatively spliced mRNAs code for different polypeptide chains of the chicken neural cell adhesion molecule (N-CAM)
22. Immunoelectron-microscopic localization of the 180 kD component of the neural cell adhesion molecule N-CAM in postsynaptic membranes
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26. Homophilic adhesion mediated by the neural cell adhesion molecule involves multiple immunoglobulin domains
27. Identification of a peptide sequence involved in homophilic binding in the neural cell adhesion molecule NCAM
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29. Identification of a neuritogenic ligand of the first Ig module of NCAM by means of a combinatorial library of synthetic peptides
30. Expression of NCAM containing VASE in neurons can account for a developmental loss in their neurite outgrowth response to NCAM in a cellular substratum
31. NCAM requires a cytoplasmic domain to function as a neurite outgrowth-promoting neuronal receptor
32. Expression of a dominant negative FGF receptor inhibits axonal growth FGF receptor phosphorylation stimulated by CAMs
33. The homophilic binding site of the neural cell adhesion molecule NCAM is directly involved in promoting neurite outgrowth from cultured neural retinal cells
34. Differential exon usage involving an unusual splicing mechanism generates at least eight types of NCAM cDNA in mouse brain
35. NCAM stimulates the Ras-MAPK pathway and CREB phosphorylation in neuronal cells
36. A role for the neural cell adhesion molecule (NCAM) in a late, consolidating phase of glycoprotein synthesis six hours following passive avoidance training of the young chick
37. Expression of the unique NCAM VASE exon is independently regulated in distinct tissues during development
38. Identification of a cDNA clone that contains the complete coding sequence for a 140-kD rat NCAM polypeptide
39. The neural cell adhesion molecules L1 and NCAM-180 act in different steps of neurite outgrowth
40. The three-dimensional structure of the first domain of neural cell adhesion molecule
41. Genetic deletion of a neural cell adhesion molecule variant (N-CAM-180) produces distinct defects in the central nervous system
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44. Unbiased stereological estimation of the number of neurons in the human hippocampus
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