Functional analysis of the CD8+CD57+ cell population in normal healthy individuals and matched unrelated T-cell-depleted bone marrow transplant recipients

British Journal of Haematology

Volumn 110, Issue 2, 2000, Pages 315-321

  Rowbottom, A W ^a   Garland, R J ^a   Lepper, M W ^a   Kaneria, S S ^a   Goulden, N J ^a,b   Oakhill, A ^b   Steward, C G ^a,b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b BRISTOL ROYAL HOSPITAL FOR CHILDREN   (United Kingdom)

Author keywords

Bone marrow transplantation. CD8. CD57; Cytomegalovirus; Interleukin 2

Indexed keywords

CD57 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 2;

ALLOGENIC BONE MARROW TRANSPLANTATION; ANTIGEN EXPRESSION; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS INFECTION; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; VIRUS REACTIVATION;

ADOLESCENT; ADULT; ANTIGENS, CD3; ANTIGENS, CD57; ANTIGENS, CD8; BONE MARROW TRANSPLANTATION; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-2; LYMPHOCYTE DEPLETION; T-LYMPHOCYTES; TRANSPLANTATION IMMUNOLOGY; TUMOR NECROSIS FACTOR-ALPHA; VIRUS ACTIVATION;

EID: 0033836257     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.02107.x     Document Type: Article

References (12)

1. + T lymphocytes are derived from CD57- precursors by differentiation occurring in late immune responses
2. Expansion of CD8+CD57+ T cells after allogeneic BMT is related with a low incidence of relapse and with cytomegalovirus infection
3. The use of Teflon cell culture bags to expand functionally active CD8+ cytotoxic T lymphocytes
4. Recall response to cytomegalovirus in allograft recipients: Mobilization of CD57+, CD28+ cells before expansion of CD57+, CD28- cells within the CD8+ T lymphocyte compartment
5. The enigma of CD57 + CD28- T cell expansion - Anergy or activation?
6. Anergy and apoptosis in CD8+ T cells from HIV-infected persons
7. Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts
8. Interleukin-10-induced CD8 cell proliferation
9. A lectin-binding soluble factor released by CD8+CD57+ lymphocytes from AIDS patients inhibits T cell cytotoxicity
10. An inhibitor of cytotoxic functions produced by CD8+CD57+ T lymphocytes from patients suffering from AIDS and immunosuppressed bone marrow recipients
11. CD8 (high) (CD57+) T cells in normal, healthy individuals specifically suppress the generation of cytotoxic T lymphocytes to Epstein-Barr virus-transformed B cell lines
12. CD8highCD57+ T lymphocytes in normal, healthy individuals are oligoclonal and respond to human cytomegalovirus