Propofol combined with diazepam synergistically potentiates the GABA-activated chloride current in rat sensory neurons

Chinese Medical Journal

Volumn 113, Issue 9, 2000, Pages 840-843

  Luo, Ailin ^a   Kazuhide, Sugiyama ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b NONE

Author keywords

Diazepam; Electrical; Physiology; Propofol; R aminobutyric acid

Indexed keywords

4 AMINOBUTYRIC ACID; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; CHLORIDE; DIAZEPAM; HALOTHANE; INHALATION ANESTHETIC AGENT; ISOFLURANE; PROPOFOL; SEVOFLURANE;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING SITE; CHLORIDE CURRENT; DATA ANALYSIS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG POTENTIATION; MEMBRANE POTENTIAL; NERVE CELL; NONHUMAN; PATCH CLAMP; PH; PRESSURE MEASUREMENT; RAT; RECEPTOR BINDING; SENSORY NERVE CELL; SPINAL GANGLION;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; CHLORIDE CHANNELS; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; GAMMA-AMINOBUTYRIC ACID; GANGLIA, SPINAL; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; PROPOFOL; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 0033835662     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Tanelian DL, Kosek P, Mody I, et al. The role of the GABAA receptor/chloride channel complex in anesthesia. Anesthesiology 1993;78:757-776.
2. Franks NP, Lieb WR. Molecular and cellular mechanisms of general anesthesia. Nature 1994;367:607-614.
3. Short TG, Chui PT. Propofol and midazolam act synergistically in combination. Br J Anesth 1991;67:539-545.
4. McClune S, McaKay AC, Wright PMS, et al. Synergistic interaction between midazolam and propofol. Br J Anaesth 1992;69:240-245.
5. Ailin Luo, Kazuhide Sugiyama. Propofol enhances GABA-induced chloride current in cultured rat ganglionic neurons. Chin J Anaesth 1999;19:155-157.
6. Reves JG, Glass PSA, Lubarsky DA. Nonbarbiturate intravenous anesthetics, anesthesia. In: Miller RD, ed. New York: Churchill Livingstone; 1994:247-289.
7. A receptor activation in human recombinant receptors. Eur J Pharmacol 1996;314;151-156.
8. Harris RA, Mihic SJ, Dildy-Marfield JE, et al. Actions of anesthetics on ligand-gated ion channels: role of receptor subunit composition. FASEB J 1995;9:1454-1462.
9. Short TG, Galletly DC, Plummer JL, et al. Hypnotic and anesthetic actions of thiopentone and midazolam alone and in combination. Br J Anaesth 1991;66:13-19.
10. Teh J, Short TG, Wong J, et al. Pharmacokinetic interactions between midazolam and propofol: an infusion study. Br J Anaesth 1994; 72:62-65.