Extensive intra-tumor heterogeneity in primary human glial tumors as a result of locus non-specific genomic alterations

Journal of Neuro-Oncology

Volumn 48, Issue 1, 2000, Pages 1-12

  Misra, A ^a   Chattopadhyay, P ^a   Dinda, A K ^a   Sarkar, C ^a   Mahapatra, A K ^a   Hasnain, S E ^b   Sinha, S ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

Author keywords

DNA fingerprinting; Genetic heterogeneity; Human astrocytic tumors; p53; RAPD analysis

Indexed keywords

DNA; PROTEIN P53;

ARTICLE; ASTROCYTOMA; CANCER GRADING; CARCINOGENESIS; CELL COMPARTMENTALIZATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA FINGERPRINTING; GENE LOCUS; GENETIC ANALYSIS; GENETIC HETEROGENEITY; GLIOBLASTOMA; GLIOMA; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; RANDOM AMPLIFIED POLYMORPHIC DNA; RANDOMIZED CONTROLLED TRIAL; TUMOR;

BRAIN NEOPLASMS; DNA FINGERPRINTING; GENETIC HETEROGENEITY; GLIOBLASTOMA; HUMANS; LOSS OF HETEROZYGOSITY; RANDOM AMPLIFIED POLYMORPHIC DNA TECHNIQUE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033834289     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006435201961     Document Type: Article

References (49)

1. Tumor heterogeneity
2. Differential response by human melanoma cells to 1,3-bis-(1-nitrosourea) and bleomycin
3. Clinical and pharmacological implications of cancer cell differentiation and heterogeneity
4. Heterogeneous expression of cell surface antigens in normal epithelia and their tumors revealed by monoclonal antibodies
5. Monoclonal antibody against tumor derived cell line, shows heterogeneity of altered hepatocytes during AFB-induced carcinogenesis
6. Gamma-glutamyl-transpeptidase and the ras-induced transformation of a rat liver cell line
7. Heterogeneity of tumor cells from a single mouse mammary tumor
8. Tumor etiology and chromosome pattern
9. The chromosomes of fifty primary Rous rat sarcomas
10. The shifting balance theory and macroevolution
11. Intratumoral histologic heterogeneity of gliomas. A quantitative study
12. Regional heterogeneity in the proliferative activity of human gliomas as measured by the Ki-67 labeling index
13. BCNU-sensitivity in parental cells and clones from four freshly resected near-diploid human gliomas: An astrocytoma, an anaplastic astrocytoma and two glioblastoma multiforme
14. Immunohistochemical determination of protein kinase C expression and proliferative activity in human brain tumors
15. Regional glucose metabolism and histopathology of gliomas
16. Isolation, karyotype, and clonal growth of heterogeneous subpopulations of human malignant gliomas
17. Regional heterogeneity in the DNA content of human gliomas
18. Cytogenetic and flow cytometry DNA analysis of regional heterogeneity in a low grade human glioma
19. Clonal expansion of p53 mutant cells is associated with brain tumor progression
20. Cellular and tumoral heterogeneity of EGFR gene amplification in human malignant gliomas
21. Loss of heterozygosity of a locus on 17p13.3, independent of p53, is associated with higher grades of astrocytic tumors
22. Alterations in brain tumor DNA detected by a fingerprinting probe
23. Alteration in brain tumor genomes identified by RAPD analysis
24. Detection of genomic instability in lung cancer tissues by random amplified polymorphic DNA analysis
25. p53 activates expression of HIC-1, a new candidate tumor suppressor gene on 17p13.3
26. Biological and experimental consequences of the zonal composition of solid tumours
27. Loss of heterozygosity of p53 in oral cancers demonstrated by the polymerase chain reaction
28. Polymerase chain reaction detection of a highly polymorphic VNTR segment in intron 1 of human p53 gene
29. Dinucleotide repeat polymorphism mapping to the critical region for lissencephaly (17p13.3)
30. Genetic analysis using random amplified polymorphic DNA markers
31. Detection of somatic changes in human cancer DNA by DNA fingerprinting analysis
32. DNA fingerprinting survey of various human tumors and their metastases
33. Artifactual variation in randomly amplified polymorphic DNA banding patterns
34. Heteroduplex molecules formed between allelic sequences cause nonparental RAPD bands
35. Randomly amplified polymorphic DNA fingerprinting using combinations oligonucleotide primers
36. Anomalies in direct pair wise comparisons of RAPD fragments for genetic analysis
37. Effect of transition interval between melting and annealing temperature on RAPD analysis
38. Assessment of genomic damage in colorectal cancer by DNA fingerprinting: Prgnostic applications
39. DNA amplification fingerprinting using very short arbitrary oligonucleotide primers
40. Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction
41. Detection of mutation(s) or polymorphic loci in the genome of experimental animal and human cancer tissues by RAPD/AP-PCR depends on DNA polymerase
42. Patterns of tumor growth and problems associated with histological typing of low-grade gliomas
43. Oligodendrogliomas. Part I: Patterns of growth, histological diagnosis, clinical and imaging correlations: A study of 153 cases
44. Evidence of focal genetic microheterogeneity in glioblastoma multiforme by area specific CGH on microdissected tumor cells
45. Anti-angiogenic therapy of experimental cancer does not induce acquired drug resistance
46. Growth interaction in vivo between tumor subpopulations derived from a single mouse mammary tumor
47. Tumors of the nervous system
48. Postoperative radiotherapy of supra-tentorial low-grade gliomas