Effects of the 2-amino-3hydroxy-5-methyl-4-isoxazole-proprionic acid/kainate antagonist LY293558 on spontaneous and evoked postoperative pain

Clinical Pharmacology and Therapeutics

Volumn 68, Issue 3, 2000, Pages 320-327

  Gilron, Ian ^a,b,c   Max, Mitchell B ^a,b,c   Lee, Gloria ^a,b,c   Booher, Susan L ^a,b,c   Sang, Christine N ^a,b,c   Chappell, Amy S ^a,b,c   Dionne, Raymond A ^a,b,c  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR ANTAGONIST; DECAHYDRO 6 [2 (1H TETRAZOL 5 YL)ETHYL] 3 ISOQUINOLINECARBOXYLIC ACID; KETOROLAC TROMETAMOL; LIDOCAINE; MIDAZOLAM; PLACEBO;

ADULT; ANALGESIA; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERANCE; EVOKED RESPONSE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; ORAL SURGERY; PAIN ASSESSMENT; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEDATION; SURGICAL TECHNIQUE; TOOTH EXTRACTION; TREATMENT OUTCOME; VISUAL IMPAIRMENT;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; ISOQUINOLINES; KETOROLAC; MALE; ORAL SURGICAL PROCEDURES; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; TETRAZOLES;

EID: 0033830023     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1067/mcp.2000.108677     Document Type: Article

References (30)

1. The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury
2. Role of excitatory amino acid receptors in the mediation of the nociceptive response to formalin in the rat
3. Antinociceptive effects of NMDA and non-NMDA receptor antagonists in the tail flick test in mice
4. Kainate GluR5 receptor subtype mediates the nociceptive response to formalin in the rat
5. Actions of kainate and AMPA selective glutamate receptor ligands on nociceptive processing in the spinal cord
6. Kainate-receptor-mediated sensory synaptic transmission in mammalian spinal cord
7. Region-specific expression of subunits of ionotropic glutamate receptors (AMPA-type, KA-type and NMDA receptors) in the rat spinal cord with special reference to nociception
8. Peripheral administration of NMDA, AMPA or KA results in pain behaviors in rats
9. Neuropharmacology of AMPA and kainate receptors
10. AMPA/kainate antagonist LY293558 reduces capsaicin-evoked hyperalgesia but not pain in normal skin in humans
11. Contribution of central neuroplasticity to pathological pain: Review of clinical and experimental evidence
12. Preemptive analgesia - Treating postoperative pain by preventing the establishment of central sensitization
13. Oral surgery
14. Pencil and paper tests-sensitivity to psychotropic drugs
15. Clinical evaluation of H1 receptor and H2 receptor antagonists for acute postoperative pain
16. Comparison of the efficacy and safety of ketorolac and meperidine in the relief of dental pain
17. Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus
18. Pain sensation and nociceptive reflex excitability in surgical patients and human volunteers
19. Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery
20. The nurse-observer and the conduct of clinical trials
21. Postoperative pain after inguinal herniorrhaphy with different types of anesthesia
22. Preemptive effect of fentanyl and ketamine on postoperative pain and wound hyperalgesia
23. Alfentanil dose-response relationships for relief of postoperative pain
24. Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: Stereospecificity and selectivity profiles
25. Pharmacological discrimination of GluR5 and GluR6 kainate receptor subtypes by (3S,4aR,6R,8aR)-6-[2(1(2)H-tetrazole-5-yl)ethyl]decahydroisdoquinoline-3 carboxylic-acid
26. Glutamate receptor profile of the AMPA/kainate receptor antagonist LY293558
27. Reduction in joint swelling and hyperalgesia following post-treatment with a non-NMDA glutamate receptor antagonist
28. Analgesic interaction between intrathecal midazolam and glutamate receptor antagonists on thermal-induced pain in rats
29. The role of non-N-methyl-D-aspartate ionotropic glutamate receptors in the spinal transmission of nociception in normal animals and animals with carrageenan inflammation
30. Generation and analysis of GluR5(Q636R) kainate receptor mutant mice