Ethanol pharmacokinetics in white women: Nonlinear model fitting versus zero-order elimination analyses

Alcoholism: Clinical and Experimental Research

Volumn 24, Issue 9, 2000, Pages 1353-1362

  Mumenthaler, Martin S ^a   Taylor, Joy L ^b   Yesavage, Jerome A ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

Compartmental Model; Ethanol Pharmacokinetics; Female; Michaelis Menten; Zero Order Kinetics

Indexed keywords

ALCOHOL;

ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; ARTICLE; BREATH ANALYSIS; COMPARTMENT MODEL; CONTROLLED STUDY; FEMALE; HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INTERMETHOD COMPARISON; MENSTRUAL CYCLE; MICHAELIS MENTEN KINETICS; NONLINEAR SYSTEM; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0033829144     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2000.tb02103.x     Document Type: Article

References (53)

1. Sex differences in the metabolism of ethanol and acetaldehyde in normal subjects
2. SAAM II: Simulation, analysis, and modeling software for tracer and pharmacokinetic studies
3. Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism
4. Validation of simple and complex models in physiology and medicine
5. Compartmental models: Theory and practice using the SAAM II software system
6. Ethanol metabolism in men and women
7. Developing and testing integrated multicompartment models to describe a single-input multiple-output study using the SAAM II software system
8. High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism
9. Pharmacokinetics of ethanol drinking - Absorption kinetics and first-pass effect
10. Parallel first-order and Michaelis-Menten elimination kinetics of ethanol. Respective role of alcohol dehydrogenase (ADH), non-ADH and first-order pathways
11. On the identification of Michaelis-Menten elimination parameters from a single does-response curve
12. A pharmacokinetic/pharmacodynamic comparison of SAAM II and PC/WinNonlin modeling software
13. Clinical pharmacokinetics of ethanol
14. The effects of several weeks of ethanol consumption on ethanol kinetics in normal men and women
15. Interindividual variations in the disposition and metabolism of ethanol in healthy men
16. Ethanol metabolism in women taking oral contraceptives
17. Neue Methoden zur pharmakokinetischen Beschreibung des Alkohols und seiner Metaboliten bei weiblichen und mannlichen Versuchspersonen
18. Problems associated with average alcohol consumption and frequency of intoxication in a medical population
19. The kinetics of alcohol elimination in man
20. The pharmacokinetics of alcohol in human breath, venous and arterial blood after oral ingestion
21. A twin study of ethanol metabolism
22. Incidence of ovulation in young women
23. Computational problems of compartment models with Michaelis-Menten-type elimination
24. Human zinc metabolism: Advances in the modeling of stable isotope data
25. More rapid elimination of alcohol in women as compared to their male siblings
26. Fitting curves to data using nonlinear regression: A practical and nonmathematical review
27. Effects of menstrual cycle and female sex steroids on ethanol pharmacokinetics
28. Gender differences in moderate drinking effects
29. Survival after high blood alcohol levels associated with first order elimination kinetics
30. Parameter estimation in a three-compartment model for blood alcohol curves
31. Ethanol 'dose dependent' elimination: Michaelis Menten v classical kinetic analysis
32. The mathematics behind modeling
33. Non-uniformity of blood ethanol elimination: Its exaggeration after chronic consumption
34. Mathematical modelling of ethanol metabolism in normal subjects and chronic alcohol misusers
35. Acute alcohol intoxication: Sex comparison on pharmacokinetic and mood measures
36. Acute alcohol intoxication in women: Relationship to dose and menstrual cycle phase
37. Acute alcohol intoxication, mood states and alcohol metabolism in women and men
38. Alcohol elimination and simulator performance of male and female aviators: A preliminary report
39. Kinetic evaluation of nonlinear drug elimination by a disposition decomposition analysis. Application to the analysis of the nonlinear elimination kinetics of erythropoietin in adult humans
40. Aging and ethanol metabolism
41. Parameters V(m)' and K(m) for elimination of alcohol in young male subjects following low doses of alcohol
42. Elimination of alcohol from human blood
43. Total body water volumes for adult males and females estimated from simple anthropometric measurements
44. Prediction of blood alcohol concentrations in human subjects: Updating the Widmark equation
45. Pharmacokinetics of ethanol after oral administration in the fasting state
46. Menstrual cycle and oral contraceptive effects on alcohol pharmacokinetics in Caucasian females