Modulation of humoral immune responses in the rat by centrally applied Met-Enk and opioid receptor antagonists: Functional interactions of brain OP1, OP2 and OP3 receptors

Immunopharmacology

Volumn 49, Issue 3, 2000, Pages 255-262

  Dimitrijevi, Mirjana ^a   Stanojevi, Stanislava ^a   Kovacevi Jovanovi, Vesna ^a   Mileti, Tatjana ^a   Vuji Redzi, Vesna ^b   Radulovi, Jelena ^c  

^a Institute of Virology Vaccines and Sera Torlak Immunology Research Centre Branislav Jankovi   (Serbia)

^b Dedinje Cardiovascular Institute   (Serbia)

^c Max Planck Institute for Experimental Medicine   (Serbia)

Author keywords

Central nervous system; Leucine enkephalin; Methionine enkephalin; OP1; OP2; OP3; Opioid receptors; Plaque forming cell response

Indexed keywords

BETA FUNALTREXAMINE; BINALTORPHIMINE; BRAIN RECEPTOR; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR ANTAGONIST; LEUCINE ENKEPHALIN; METENKEPHALIN; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR ANTAGONIST; N,N DIALLYLTYROSYL 2 METHYLALANYL 2 METHYLALANYLPHENYLALANYLLEUCINE; NALTRINDOLE; OPIATE; OPIATE AGONIST; OPIATE ANTAGONIST; OPIATE RECEPTOR; RECEPTOR SUBTYPE; SIGMA 1 OPIATE RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SPECIFICITY; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOSTIMULATION; MALE; NONHUMAN; PLAQUE FORMING CELL; PRIORITY JOURNAL; RAT;

EID: 0033829010     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-3109(00)00213-7     Document Type: Article

References (34)

1. W.T. Adamson R.T. Windh S. Blackford C.M. Kuhn Ontogeny of mu- and kappa-opiate receptor control of the hypothalamo-pituitary-adrenal axis Endocrinology 129 1991 959 964
2. L. Alessio S. Govoni G. Salar F. Battaini R. Iavicoli M. Trabucchi Age-related-changes of methionine–enkephalin and beta-endorphin beta-lipotropin immunoreactivity in human CSF Life Sci. 43 1988 1545 1550
3. J. Antić T. Vasiljević S. Stanojević V. Vujić V. Kovac̆ević-Jovanović D. Djergović C̆. Miljević B.M. Marković J. Radulović Suppression of adjuvant arthritis by κ-opioid receptor agonist: effects of route of administration and strain differences Immunopharmacology 34 1996 105 112
4. D.G. Baker S.A. West D.N. Orth K.K. Hill W.E. Nicholson N.N. Ekhator A.B. Bruce M.D. Wortman P.E. Keck T.D. Geracioti Cerebrospinal fluid and plasma beta-endorphin in combat veterans with post-traumatic stress disorder Psychoneuroendocrinology 22 1997 517 529
5. E.A. Barnard C. Demoliou-Mason Molecular properties of opioid receptors Br. Med. Bull. 39 1983 37 46
6. S. Basu P.S. Dasgupta Dopamine, a neurotransmitter, influences the immune system J. Neuroimmunol. 102 2000 113 124
7. M. Bertolucci C. Perego M.G. De Simoni Central opiate modulation of peripheral IL-6 in rats NeuroReport 7 1996 1181 1184
8. T.-H. Bian X.-F. Wang X.-Y. Li Effects of morphine and naloxone on proliferation of lymphocytes in vitro Acta Pharmacol. Sinica 16 1995 315 318
9. D.J. Carr B.M. Gebhardt D. Paul Alpha adrenergic and mu-2 opioid receptors are involved in morphine-induced suppression of splenocyte natural killer activity J. Pharmacol. Exp. Ther. 264 1993 1179 1186
10. R. D'Amato J.W. Holaday Multiple opioid receptors in endotoxic shock: evidence for δ involvement and μ–δ interactions in vivo Proc. Natl. Acad. Sci. 81 1984 2898 2901
11. F. Fecho L.A. Dykstra D.T. Lysle Evidence for beta adrenergic receptor involvement in the immunomodulatory effects of morphine J. Pharmacol. Exp. Ther. 265 1993 1079 1087
12. C. Gavériaux-Ruff H.W. Matthes J. Peluso B.L. Kieffer Abolition of morphine-immunosuppression in mice lacking the mu-opioid receptor gene Proc. Natl. Acad. Sci. U. S. A. 95 1998 6326 6330
13. R.V. House P.T. Thomas H.N. Bhargava A comparative study of immunomodulation produced by in vitro exposure to delta opioid receptor agonist peptides Peptides 17 1996 75 81
14. T.K. Eisenstein J.J. Meissler Jr. T.J. Rogers E.B. Geller W.M. Adler Mouse strain differences in immunosuppression by opioids in vitro J. Pharmacol. Exp. Ther. 275 1995 1484 1489
15. B.D. Janković J. Radulović Enkephalins, brain and immunity: modulation of immune responses by methionine–enkephalin injected into the cerebral cavity Int. J. Neurosci. 67 1992 241 270
16. B.D. Janković J. Radulović Quaternary naltrexone: its immunomodulatory activity and interaction with brain delta and kappa opioid receptors Immunopharmacology 28 1994 105 112
17. B.D. Janković N.H. Spector Effects on the immune system of lesioning and stimulation of the nervous system: neuroimmunomodulation N.P. Plotnikoff R.E. Faith A.J. Murgo R.A. Good Enkephalins and endorphins Stress and the Immune System 1986 Plenum New York 189 220
18. M. Langemark F.W. Bach R. Ekman J. Olesen Increased cerebrospinal-fluid met–enkephalin immunoreactivity in patients with chronic tension-type headache Pain 63 1995 103 107
19. A. Mansour H. Khatchaturian M.E. Lewis H. Akil S.J. Watson Anatomy of CNS opioid receptors Trends Neurosci. 11 1988 308 314
20. H.W. Matthes C. Smadja O. Valverde J.L. Vonesch A.S. Foutz E. Boudinot M. Denavit-Saubié C. Severini L. Negri B.P. Roques R. Maldonado B.L. Kieffer Activity of the delta-opioid receptor is partially reduced, whereas activity of the kappa-receptor is maintained in mice lacking mu-receptor J. Neurosci. 18 1998 7285 7295
21. R.D. Mellon B.M. Bayer Decreased blood lymphocyte proliferative responses mediated by central μ-receptors Soc. Neurosci. Abstr. 22 1996 1314
22. F. Porreca A.E. Takemori M. Sultana P.S. Porthogese W.D. Bowen H.I. Mosberg Modulation of mu-mediated antinociception in the mouse involves opioid delta-2 receptors J. Pharmacol. Exp. Ther. 263 1992 147 152
23. J. Radulović B.D. Janković Opposing activities of brain opioid receptors in the regulation of humoral and cell-mediated immune responses in the rat Brain Res. 661 1994 189 195
24. J. Radulović C̆. Miljević D. Djergović V. Vujić J. Antić S. Von Hörsten B.D. Janković Opioid-receptor mediated suppression of humoral immune response in vivo and in vitro: involvement of κ opioid receptors J. Neuroimmunol. 57 1995 55 62
25. J. Radulović Z. Manc̆ev S. Stanojević T. Vasiljević V. Kovac̆ević-Jovanović G. Pešić Modulation of humoral immune response by central administration of leucine–enkephalin: effects of μ, δ and κ opioid receptor antagonists J. Neuroimmunol. 65 1996 155 161
26. R.B. Rothman J.B. Long V. Bykov A.E. Jacobson K.C. Rice J.W. Holaday β-FNA binds irreversibly to opiate receptor complex: in vivo and in vitro evidence J. Pharmacol. Exp. Ther. 247 1988 405 416
27. B.M. Sharp N.A. Shahabi W. Heagy K. McAllen M. Bell C. Huntoon D.J. McKean Dual signal transduction through delta opioid receptors in a transfected human T-cell line Proc. Natl. Acad. Sci. 93 1996 8294 8299
28. Y. Shavit A. DePaulis F.C. Martin G.W. Terman R.N. Pechnick C.J. Zane R.P. Gale J.C. Liebeskind Involvement of brain opiate receptors in the immunosuppressive effects of morphine Proc. Natl. Acad. Sci. U. S. A. 83 1986 7114 7717
29. Y. Shavit G.W. Terman J.W. Lewis C.J. Zane R.P. Gale J.C. Liebeskind Effects of footshock stress and morphine on natural killer lymphocytes in rats: studies on tolerance and cross-tolerance Brain Res. 372 1986 382 385
30. M. Sofuoglu P.S. Porthogese A.E. Takemori Differential antagonism of delta opioid agonost by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes J. Pharmacol. Exp. Ther. 257 1991 676 680
31. 5]enkephalin-induced analgesia Eur. J. Pharmacol. 324 1997 R1 R2
32. D.D. Taub T.K. Eisenstein E.B. Geller M.W. Adler T.J. Rogers Immunomodulatory activity of mu-and kappa-selective opioid agonists Proc. Natl. Acad. Sci. U. S. A. 88 1991 360 364
33. S. Von Hörsten H. Nave J. Ballof F. Helfritz D. Meyer R.E. Schmidt M. Stalp N.G. Exton M.S. Exton R.H. Straub J. Radulović R. Pabst Centrally applied NPY mimics immunoactivation induced by non-analgesic doses of met–enkephalin NeuroReport 9 1998 3881 3885
34. R.Q. Wan V.M. Wiegant W. deJong D. deWied Alterations of beta-endorphin-like immunoreactivity in CSF following behavioral training using a passive avoidance procedure Psychoneuroendocrinology 21 1996 503 513