A trypsin-sensitive protein is required for utilization of exogenous cholesterol for pregnenolone synthesis by placental mitochondria

Placenta

Volumn 21, Issue 7, 2000, Pages 654-660

  Espinosa Garcia M T ^a   Strauss III, Jerome F ^b   Martinez F ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

22 HYDROXYCHOLESTEROL; ADENINE NUCLEOTIDE TRANSLOCASE; CHOLESTEROL; MITOCHONDRIAL ENZYME; PLACENTA PROTEIN; PREGNENOLONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REGULATOR PROTEIN; STEROID HORMONE; SUCCINATE DEHYDROGENASE; SUCROSE; TRYPSIN;

ADRENAL GLAND; ARTICLE; CENTRIFUGATION; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVITY; GONAD; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; MEMBRANE TRANSPORT; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; OXYGEN CONSUMPTION; PLACENTA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; STEROIDOGENESIS; SYNCYTIOTROPHOBLAST;

EID: 0033828847     PISSN: 01434004     EISSN: None     Source Type: Journal    
DOI: 10.1053/plac.2000.0562     Document Type: Article

References (43)

1. Modulatory action of benzodiazepines on human term placental steroidogenesis in vitro
2. Contact sites between mitochondrial envelope membranes. Structure and function in energy- and protein-transfer
3. The molecular structure of mitochondrial contact sites. Their role in regulation of energy metabolism and permeability transition
4. The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR)
5. Hormonal and developmental regulation of the steroidogenic acute regulatory protein
6. Pregnenolone radioimmunoassay utilizing a new fractionation technique for sheep antiserum
7. Cholesterol increase in mitochondria: Its effect on inner-membrane functions, submitochondrial localization and ultrastructural morphology
8. Regulation of steroid hormone synthesis
9. Intracellular cholesterol transport
10. Fibroblast membrane sterol kinetic domains: Modulation by sterol carrier protein-2 and liver fatty acid binding protein
11. Spontaneous and protein-mediated sterol transfer between intracellular membranes
12. Pore formation in lipid bilayer membrane made of phosphatidylinositol and oxidized cholesterol followed by means of alternating current
13. The biosynthesis of steroid hormones: An up-date
14. The human steroidogenic acute regulatory (StAR) gene is expressed in the urogenital system and encodes a mitochondrial polypeptide
15. Cytochromes P450 and the regulation of steroid synthesis
16. Steroidogenic enzymes: Structure, function, and role in regulation of steroid hormone synthesis
17. Adenine nucleotide translocation in cauliflower mitochondria
18. Regulation of cholesterol movement to mitochondrial cytochrome P450scc in steroid hormone synthesis
19. Protein measurement with the Folin phenol reagent
20. Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis
21. Cholesterol increase in mitochondria: A new method of cholesterol incorporation
22. Respiratory control induced by ATP in human term placental mitochondria
23. Structural and functional changes in mitochondria associated with trophoblast differentiation: Method to isolate enriched preparations of syncytiotrophoblast mitochondria
24. Regulation of mitochondrial cholesterol metabolism
25. Differences in cholesterol incorporation into mitochondria from hepatoma AS-30D and human term placenta
26. Distinctive properties of adrenal cortex mitochondria
27. Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: Biological role in steroidogenic cell function
28. Sterol carrier protein 2: A role in steroid hormone synthesis?
29. Role of sterols in the functional reconstitution of water-soluble mitochondrial porins from different organisms
30. Recent advances in membrane cholesterol domain dynamics and intracellular cholesterol trafficking
31. L-3-glycerol phosphate oxidation with energy coupling in submitochondrial particles from skeletal muscle mitochondria
32. The 30-kDa mitochondrial proteins induced by hormone stimulation in MA-10 mouse Leydig tumor cells are processed from larger precursors
33. Presence of identical mitochondrial proteins in unstimulated constitutive steroid-producing R2C rat Leydig tumor and stimulated nonconstitutive steroid-producing MA-10 mouse Leydig tumor cells
34. Role of the steroidogenic acute regulatory protein (StAR) in steroidogenesis
35. Placental steroid hormone synthesis: Unique features and unanswered questions
36. Human steroidogenic acute regulatory protein: Functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and pseudogene to chromosome 13
37. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
38. Cholesterol side-chain cleavage by mitochondria from the human placenta. Studies using hydroxycholesterols as substrates
39. MLN64 contains a domain with homology to the steroidogenic acute regulatory protein (StAR) that stimulates steroidogenesis
40. Affinity chromatography of human plasma low- and high-density lipoproteins
41. Cloning and expression of a cDNA encoding human sterol carrier protein 2
42. VDAC, a mitochondrial outer membrane channel: Physiological regulation and biophysical properties