Effects of nilvadipine, nicardipine and verapamil on acute rise of aqueous flare induced by iris photocoagulation or intravenous lipopolysaccharides in pigmented rabbits

Ophthalmic Research

Volumn 32, Issue 5, 2000, Pages 205-209

  Zhang, Xue Yun ^a   Hiraki, Shigeyoshi ^a   Kadoi, Chiharu ^a   Hayasaka, Seiji ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Aqueous flare; Argon laser photocoagulation; Lipopolysaccharides; Nicardipine; Nilvadipine; Verapamil

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; NICARDIPINE; NILVADIPINE; VERAPAMIL;

ANIMAL EXPERIMENT; ARGON LASER; ARTICLE; DRUG EFFECT; EYE INFLAMMATION; LASER COAGULATION; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

EID: 0033828492     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000055614     Document Type: Article

References (21)

1. 2 reaction in rabbit eyes. J Jpn Ophthalmol Soc 1994;98: 825-831.
2. Kaji Y, Hiraki S, Hirata H, Hayasaka S: Nicardipine inhibits acute rise of aqueous flare and intraocular pressure induced by argon laser photocoagulation. Ocul Immunol Inflamm 1996;4:139-144.
3. 2 in pigmented rabbits. Ophthalmic Res 1998;30: 135-141.
4. Sawa M, Tsurimaki Y, Tsuru T, Shimizu H: New quantitative method to determine protein concentration and cell number in aqueous in vivo. Jpn J Ophthalmol 1988;32:132-142.
5. Yano H, Hiraki S. Hayasaka S: Effects of Kakkon-to and Sairei-to on experimental elevation of aqueous flare in pigmented rabbits. Jpn J Ophthalmol, in press.
6. Weinreb RN, Weaver D, Mitchell MD: Prostanoids in rabbit aqueous humor: Effect of laser photocoagulation of the iris. Invest Ophthalmol Vis Sci 1985;26:1087-1092.
7. Joo CK, Kim JH: Prostaglandin E in rabbit aqueous humor after Nd-YAG laser photodisruption of iris and the effect of topical indomethacin pretreatment. Invest Ophthalmol Vis Sci 1992;33:1685-1689.
8. Taniguchi T, Kawakami H, Sawada A, Iwaki M. Tsuji A, Sugiyama K, Kitazawa Y: Effects of nitric oxide synthase inhibitor on intraocular pressure and ocular inflammation following laser irradiation in rabbits. Curr Eye Res 1998; 17:308-315.
9. Cousins SW, Guss RB, Howes EL, Rosenbaum JT: Endotoxin-induced uveitis in the rat: Observations on altered vascular permeability, clinical findings and histology. Exp Eye Res 1984;39:665-676.
10. Howes EL, Cole PW, Adair TM, Cruse VK, Pollycove M: Cellular and vascular responses in acute experimental ocular inflammation. Invest Ophthalmol Vis Sci 1994;35:4031-4038.
11. Devos AF, Vanharen MAC, Verhagen VHC, Verhagen C, Hoekzema R, Kijlstra A: Kinetics of intraocular tumor necrosis factor and interleukin-6 in endotoxin-induced uvetis in the rat. Invest Ophthalmol Vis Sci 1994;35:1100-1106.
12. Yoshida M, Yoshimura N, Hangai M, Tanihara H, Honda Y: Interleukin-1α, interleukin-1β and tumor necrosis factor gene expression in endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 1994;35:1107-1113.
13. Fischer BE, Van Zee KJ, Marano MA, Rock C, Kenney JS, Poutsiaka D, Dinarello C, Lowry SF, Moldawer LL: Interleukin-1 receptor antagonist circulates in experimental inflammation and in human disease. Blood 1992;79: 2196-2200.
14. Herbort CP, Okumura A, Mochizuki M: Endotoxin-induced uveitis in the rat: A study of the role of inflammation mediators. Graefe's Arch Clin Exp Ophthalmol 1988;226:553-558.
15. Bellot JL, Palmero M, Alcoriza N, Blanco A, Garcia-Cabanes C, Hariton C, Orts A: Concomitant treatment with a 5-lipoxygenase inhibitor improves the anti-inflammatory effect of the inhibition of nitric oxide synthase during the early phase of endotoxin-induced uveitis in the rabbit. Ophthalmic Res 1997;29:227-236.
16. G-nitro-L-arginine. Invest Ophthalmol Vis Sci 1994;35:3673-3680.
17. Parks D, Cheung MK, Chan CC, Roberge FG: The role of nitric oxide in uveitis. Arch Ophthalmol 1994;112:544-547.
18. Oyanagui Y, Sato S: Inhibition by nilvadipine of ischemie and carrageenan paw edema as well as of superoxide radical production from neutrophils and xanthine oxidase. Arzneimittelforschung (Drug Res) 1991;41:469-474.
19. Gallar J, de la Rubia PG, Gonzalez GG, Belmonte C: Irritation of the anterior segment of the eye by ultraviolet radiation: Influence of nerve blockade and calcium antagonists. Curr Eye Res 1995;5:827-835.
20. Northover AM: Inhibition by calcium antagonists of shape changes induced in vitro by proinflammatory mediators in venous endothelial cells. Agents Actions 1992;36:237-242.
21. 2) activity by nifedipine and nisoldipine is independent of their calcium channel-blocking activity. Inflammation 1987; 11:353-364.