Sustained long-term hematologic recovery despite a marked quantitative defect in the stem cell compartment of patients with aplastic anemia after immunosuppressive therapy

American Journal of Hematology

Volumn 65, Issue 2, 2000, Pages 123-131

  Maciejewski, J P ^a   Kim, S ^a   Sloand, E ^a   Selleri, C ^b   Young, N S ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Aplastic anemia; Long term bone marrow cultures; Progenitors; Stem cells

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR;

APLASTIC ANEMIA; ARTICLE; BLOOD SAMPLING; BONE MARROW CELL; CELL COMPARTMENTALIZATION; CELL MATURATION; CELL PROLIFERATION; COLONY FORMING CELL; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RECEPTOR UPREGULATION; RETICULOCYTE; STEM CELL;

ANEMIA, APLASTIC; BLOOD CELL COUNT; BONE MARROW CELLS; CLONE CELLS; DISEASE-FREE SURVIVAL; HEMATOPOIESIS; HEMOGLOBINURIA, PAROXYSMAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KARYOTYPING; PROSPECTIVE STUDIES; STEM CELLS; TIME FACTORS;

EID: 0033828359     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-8652(200010)65:2<123::AID-AJH6>3.0.CO;2-M     Document Type: Article

References (25)

1. Long-term culture initiating cells of blood and marrow are severely reduced in number and clonogenicity in severe aplastic anemia
2. Quantitative analysis of cobblestone area-forming cells in bone marrow of patients with aplastic anemia by limiting dilution assay
3. Stem cells, stroma, and growth factors
4. Aplastic anemia
5. The treatment of severe acquired aplastic anemia
6. Long lasting decrease of marrow and circulating long-term culture initiating cells after allogeneic bone marrow transplant
7. Deficient reconstitution of early progenitors after allogeneic bone marrow transplantation
8. Long-term marrow culture in patients with aplastic anemia compared with marrow transplant recipients and normal donors
9. The assessment of the hematopoietic reservoir after immunosuppressive therapy or bone marrow transplantation in severe aplastic anemia
10. Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro
11. Characterization of primitive hematopoietic cells in normal human peripheral blood
12. Direct comparison by limiting dilution analysis of long-term culture initiating cells in human bone marrow, umbilical cord and blood stem cells
13. Severe aplastic anemia: A prospective study of the effect of early marrow transplantation on acute mortality
14. Functional characterization of individual human hematopoietic stem cells culture at limiting dilution on supportive marrow stromal layers
15. Phenotypic and functional analysis of bone marrow progenitor cell compartment in bone marrow failure
16. Haemopoietic progenitor cells are reduced in aplastic anaemia
17. The hematopoietic defects in aplastic anemia assessed by long-term marrow culture
18. Comparison of long-term outcome of children with severe aplastic anemia treated with immuno-suppression versus bone marrow transplantation
19. Lack of in vitro colony formation in patients with severe aplastic anemia after autologous hematologic reconstitution
20. Progressive telomere shortening in aplastic anemia
21. Telomere length in myelodysplastic syndromes
22. In vivo telomere dynamics of human hematopoietic stem cells
23. Stem cell proliferation: Ex vivo and in vivo observations
24. Changes of telomere length in children after hematopoietic stem cell transplantation
25. The problem of clonality in aplastic anemia