The PDE inhibitor zaprinast enhances NO-mediated protection against vascular leakage in reperfused lungs

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 279, Issue 3 23-3, 2000, Pages

  Schütte, Hartwig ^a   Witzenrath, Martin ^a   Mayer, Konstantin ^a   Weissmann, Norbert ^a   Schell, Alexander ^a   Rosseau, Simone ^a   Seeger, Werner ^a   Grimminger, Friedrich ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Cyclic nucleotides; Lung transplantation; Microvascular permeability; Nitric oxide; Phosphodiesterase

Indexed keywords

CYCLIC GMP; NITRIC OXIDE; PHOSPHODIESTERASE INHIBITOR; ZAPRINAST;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; ISCHEMIA; LUNG ARTERY PRESSURE; LUNG TRANSPLANTATION; NONHUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; RABBIT; REPERFUSION INJURY;

EID: 0033826566     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2000.279.3.l496     Document Type: Article

References (44)

1. Analysis of time-dependent risks for infection, rejection, and death after pulmonary transplantation
2. Prevention of ischemia-reperfusion lung injury by inhaled nitric oxide in neonatal piglets
3. Protective effects of intravascular pressure and nitric oxide in ischemic lung injury
4. Low-dose nitric oxide inhalation during initial reperfusion enhances rat lung graft function
5. MandB 22948, a cGMP phosphodiesterase inhibitor, is a pulmonary vasodilator in lambs
6. Inhaled nitric oxide pretreatment but not post-treatment attenuates ischemia-reperfusion-induced pulmonary microvascular leak
7. Primary graft failure following lung transplantation
8. Nitric oxide, an endothelial relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase
9. Inhibition of cyclic 3'-5'-guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats
10. cGMP and nitric oxide modulate thrombin-induced endothelial permeability. Regulation via different pathways in human aortic and umbilical vein endothelial cells
11. Disparate effects of nitric oxide on lung ischemia reperfusion injury
12. Morphometric analysis of pulmonary intracapillary leukocyte pools in ex vivo-perfused rabbit lungs
13. Inhaled NO prevents IL-1-induced neutrophil accumulation and associated acute edema in isolated rat lungs
14. Modifying pulmonary ischemia-reperfusion injury by altering ventilatory strategies during ischemia
15. Chronic pulmonary hypertension increases fetal lung cGMP phosphodiesterase activity
16. Ventilation-perfusion mismatch after lung ischemia-reperfusion. Protective effect of nitric oxide
17. Cold ischemia-induced damage to vascular endothelium results in permeability alterations in transplanted lungs
18. Prolonged pulmonary vasodilator action of inhaled nitric oxide by zaprinast in awake lambs
19. Nitric oxide inhibits microvascular protein leakage induced by leukocyte adhesion-independent and adhesion-dependent inflammatory mediators
20. Preservation with 8-bromo-cyclic GMP improves pulmonary function after prolonged ischemia
21. NO donors prevent integrin-induced leukocyte adhesion but not P-selectin-dependent rolling in postischemic venules
22. Inhibition of nitric oxide production. Mechanisms of vascular albumin leakage
23. Modulation of ischemia/reperfusion-induced microvascular dysfunction by nitric oxide
24. Nitric oxide and cGMP regulate endothelial permeability and F-actin distribution in hydrogen peroxide-treated endothelial cells
25. The therapeutic potential of nitric oxide in lung transplantation
26. Role of nitric oxide in lung ischemia and reperfusion injury
27. Prevention of reperfusion injury by inhaled nitric oxide in lungs harvested from non-heart-beating donors
28. Effects of various timings and concentrations of inhaled nitric oxide in lung ischemia-reperfusion
29. Enhanced preservation of orthotopically transplanted rat lungs by nitroglycerin but not hydralazine. Requirement for graft vascular homeostasis beyond harvest vasodilation
30. Inhaled nitric oxide fails to confer the pulmonary protection provided by distal stimulation of the nitric oxide pathway at the level of cyclic guanosine monophosphate
31. The nitric oxide/cyclic GMP pathway in organ transplantation: Critical role in successful lung preservation
32. Inhaled nitric oxide prevents the increase in pulmonary vascular permeability caused by hydrogen peroxide
33. Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors
34. Effects of isoenzyme-selective inhibitors of cyclic nucleotide phosphodiesterase on microvascular leak in guinea pig airways in vivo
35. Vascular distension and continued ventilation are protective in lung ischemia reperfusion
36. Adult respiratory distress syndrome: Model systems using isolated perfused rabbit lungs
37. Ischemia-reperfusion injury in the isolated rat lung. Role of flow and endogenous leukocytes
38. Pulmonary reimplantation response in single lung transplantation
39. Role of nitric oxide and phosphodiesterase isoenzyme II for reduction of endothelial hyperpermeability
40. The cGMP phosphodiesterase inhibitor zaprinast enhances the effect of nitric oxide
41. Signalling by cGMP-dependent protein kinases
42. Structure, strength, failure, and remodeling of the pulmonary blood-gas barrier
43. Cyclic-GMP-mediated decrease in permeability of human umbilical and pulmonary artery endothelial cell monolayers
44. Nitric oxide and the lung