The effect in premature infants of prenatal corticosteroids on endogenous surfactant synthesis as measured with stable isotopes

American Journal of Respiratory and Critical Care Medicine

Volumn 162, Issue 3 I, 2000, Pages 844-849

  Bunt, J E H ^a   Carnielli, V P ^a   Wattimena, J L D ^a   Hop, W C ^a   Sauer, P J J ^a   Zimmermann, L J I ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BETAMETHASONE; CORTICOSTEROID; DEXAMETHASONE; GLUCOSE; PALMITIC ACID; PHOSPHOLIPID; STABLE ISOTOPE; SURFACTANT; TRIACYLGLYCEROL;

ARTICLE; BIOSYNTHESIS; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DRUG EFFECT; HUMAN; HUMAN CELL; INFANT; NEONATAL RESPIRATORY DISTRESS SYNDROME; PHOSPHOLIPID BLOOD LEVEL; PREMATURITY; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0033825736     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.162.3.9906139     Document Type: Article

References (44)

1. Antenatal corticosteroid therapy: A meta-analysis of the randomized trials, 1972 to 1994
2. Betamethasone and the rhesus fetus: Effect on lung morphometry and connective tissue
3. Repetitive prenatal glucocorticoid therapy reduces oxidative stress in the lungs of preterm lambs
4. Corticosteroids and surfactant change lung function and protein leaks in the lungs of ventilated premature rabbits
5. Effects of betamethasone on phospholipid content, composition and biosynthesis in the fetal rabbit lung
6. Hormonal regulation of pulmonary surfactant
7. The cellular mechanism of glucocorticoid acceleration of fetal lung maturation: Fibroblast-pneumonocyte factor stimulates choline-phosphate cytidylyltransferase activity
8. Transcriptional regulation of human pulmonary surfactant proteins SP-B and SP-C by glucocorticoids
9. Regulation of messenger RNAs for the hydrophobic surfactant proteins in human lung
10. Modulation of surfactant protein D expression by glucocorticoids in fetal rat lung
11. Glucocorticoids and thyroid hormones stimulate biochemical and morphological differentiation of human fetal lung in organ culture
12. Effect of dexamethasone upon surfactant phosphatidylcholine and phosphatidylglycerol synthesis in organotypic cultures of type II cells
13. Effect of hydrocortisone on the metabolism of phosphatidylcholine in maternal and fetal rabbit lungs and livers
14. Exogenous surfactant function in very preterm lambs with and without fetal corticosteroid treatment
15. Postnatal lung function in lambs after fetal hormone treatment: Effects of gestational age
16. Effect of interval from fetal corticosteriod treatment to delivery on postnatal lung function of preterm lambs
17. Minimum interval from fetal betamethasone treatment to postnatal lung responses in preterm lambs
18. Postnatal lung function in preterm lambs: Effects of a single exposure to betamethasone and thyroid hormones
19. Effects of antenatal thyrotropin-releasing hormone, antenatal corticosteroids, and postnatal ventilation on surfactant mobilization in premature rabbits
20. Experimental hyaline membrane disease in the premature monkey: Effects of antenatal dexamethasone
21. Glucocorticoid regulation of surfactant components in immature lambs
22. Surfactant in the lung and tracheal fluid of the fetal lamb and acceleration of its appearance by dexamethasone
23. Single dose versus two doses of betamethasone for lung maturation in preterm rabbits
24. Metabolism of endogenous surfactant in premature baboons and effect of prenatal steroids
25. Endogenous surfactant turnover in preterm infants measured with stable isotopes
26. Acute pulmonary X-ray changes in hyaline membrane disease treated with artificial ventilation and positive end-expiratory pressure (PEEP)
27. A rapid method of total lipid extraction and purification
28. Improved separation of phospholipids in thin layer chromatography
29. Conversion of octanoic acid into long-chain saturated fatty acids in premature infants fed a formula containing medium-chain triglycerides
30. Prospective evaluation of surfactant composition in bronchoalveolar lavage fluid of infants with congenital diaphragmatic hernia and of age-matched controls
31. Surfactant protein A, phosphatidylcholine, and surfactant inhibitors in epithelial lining fluid: Correlation with surface activity, severity of respiratory distress syndrome, and outcome in small premature infants
32. A simple method for the isolation and purification of total lipids from animal tissues
33. Gas chromatographic determination of polyols and aldoses in human urine as polyacetates and aldononitrile polyacetates
34. Measurement of albumin synthesis in humans: A new approach employing stable isotopes
35. Effect of corticosteroids for fetal maturation on perinatal outcomes, NIH Consensus Statement
36. Prenatal dexamethasone and exogenous surfactant therapy: Surface activity and surfactant components in airway specimens
37. Pharmacokinetics of bovine surfactant in neonatal respiratory distress syndrome
38. Effect of surfactant substitution on lung effluent phospholipids in respiratory distress syndrome: Evaluation of surfactant phospholipid turnover, pool size, and the relationship to severity of respiratory failure
39. Lecithin appearance and apparent biologic half-life in term newborn rabbit lung
40. Substrate utilization in the perinatal lung
41. The synthesis of phosphatidylcholine by adult rat lung alveolar type II epithelial cells in primary culture
42. Fatty acid biosynthesis in developing fetal lung
43. De novo fatty acid synthesis by freshly isolated alveolar type II epithelial cells
44. The developing rat lung fibroblast and alveolar type II cell actively recruit surfactant phospholipid substrate