Levels of mycophenolic acid and its glucuronide derivative in the plasma of liver, small bowel and kidney transplant patients receiving tacrolimus and cellcept combination therapy

Transplant Immunology

Volumn 8, Issue 2, 2000, Pages 143-146

  Tsaroucha, Alexandra K ^a,c   Zucker, Keith ^a,b   Esquenazi, Violet ^a,b   De Faria, Ludmilla ^a,b   Miller, Joshua ^a,b   Tzakis, Andreas G ^a,b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c NONE   (Greece)

Author keywords

Immunosuppression; Kidney transplantation; Liver; Mycophenolate mofetil; Mycophenolic acid; Mycophenolic acid glucuronide derivative levels; Small bowel; Tacrolimus

Indexed keywords

GLUCURONIDE; GLUCURONIDE DERIVATIVE; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG MECHANISM; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INTESTINE TRANSPLANTATION; KIDNEY DISEASE; KIDNEY TRANSPLANTATION; LIVER DISEASE; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; ORGAN DONOR; PRIORITY JOURNAL; SMALL INTESTINE DISEASE;

ADOLESCENT; ADULT; FEMALE; GLUCURONIDES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTESTINE, SMALL; KIDNEY TRANSPLANTATION; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; MYCOPHENOLIC ACID; TACROLIMUS;

EID: 0033824342     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0966-3274(00)00012-5     Document Type: Article

References (13)

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6. Tolerance induction in adult mice: CsA inhibits RS-61443-induced tolerance
7. RS-61443 for treatment-resistant human liver rejection
8. Bioavailability of mycophenolic acid through amino acid derivatization
9. RS-61443 - A phase I clinical trial and pilot rescue study
10. Metabolism and biochemistry of mycophenolic acid
11. High-performance liquid chromatographic method for the determination of mycophenolate mofetil in human plasma
12. Unexpected augmentation of mycophenolic acid pharmacokinetics in renal transplant patients receiving tacrolimus and mycophenolate mofetil in combination therapy, and analogous in vitro findings