Elimination of both cell-free and cell-associated HIV infectivity in plasma by a filtration/methylene blue photoinactivation system

Transfusion

Volumn 40, Issue 9, 2000, Pages 1081-1087

  Abe, Hideki ^a,b   Yamada Ohnishi, Yoshiko ^a   Hirayama, Junichi ^a   Owada, Takashi ^a   Ikeda, Hisami ^a   Ikebuchi, Kenji ^a  

^a JAPANESE RED CROSS SOCIETY   (Japan)

^b NONE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLENE BLUE;

ARTICLE; BLOOD CLOTTING; BLOOD FILTRATION; ERYTHROCYTE COUNT; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; INOCULATION; LEUKOCYTE COUNT; NONHUMAN; PHOTOACTIVATION; PLASMA; THROMBOCYTE COUNT; VIRUS INACTIVATION; VIRUS INFECTIVITY; VIRUS TRANSMISSION;

BLOOD COAGULATION; BLOOD COMPONENT REMOVAL; CELL CULTURE TECHNIQUES; CELL-FREE SYSTEM; ERYTHROCYTE TRANSFUSION; FILTRATION; HIV INFECTIONS; HUMANS; LEUKAPHERESIS; METHYLENE BLUE; PHOTOTHERAPY; PLATELETPHERESIS; VIRUS ACTIVATION;

EID: 0033822826     PISSN: 00411132     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1537-2995.2000.40091081.x     Document Type: Article

References (12)

1. Photoinactivation of viruses in human fresh plasma by phenothiazine dyes in combination with visible light
2. Analysis of viral DNA, protein and envelope damage after methylene blue, phthalocyanine derivatives, or merocyanine 540 photosensitization
3. Hepatitis C and human immunodeficiency virus RNA degradation by methylene blue/ light treatment of human plasma
4. Potential involvement of both Type I and Type II mechanisms in M13 virus inactivation by methylene blue photosensitization
5. Target structures for HIV-1 inactivation by methylene blue and light
6. Rapid inactivation of HW-1 in Single donor preparations of human fresh frozen plasma by methylene blue/light treatment
7. Contamination of fresh-frozen plasma with viable white cells and proliferable stem cells
8. Leukocytes can be eliminated from plasma by filtration prior to viral inactivation with methylene blue
9. Inhibition of replication and cytopathic effect of human T cell lymphotropic virus type III/lymphadenopathy-associated virus by 3'-azido-3'-deoxythymidine in vitro
10. A simple method of estimating 50 percent endpoints
11. Quantitation of human immunodeficiency virus type 1 in the blood of infected persons
12. Leukocyte-derived bioactive substances in fresh frozen plasma