Incomplete penetrance of MHC susceptibility genes: Prospective analysis of polygenic MHC-determined traits

Tissue Antigens

Volumn 56, Issue 3, 2000, Pages 199-206

  Alper, C A ^a,b   Awdeh, Z ^a  

^a CENTER FOR BLOOD RESEARCH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Autoimmunity; Incomplete penetrance; Major histocompatibility complex; Polygenic disease

Indexed keywords

ARTICLE; AUTOIMMUNITY; DOMINANT INHERITANCE; ENVIRONMENTAL FACTOR; GENE EXPRESSION; GENETIC SUSCEPTIBILITY; IMMUNOGLOBULIN DEFICIENCY; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL;

ENVIRONMENT; GENES, DOMINANT; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOGLOBULINS; MAJOR HISTOCOMPATIBILITY COMPLEX; MULTIFACTORIAL INHERITANCE; PEDIGREE; PENETRANCE; PROSPECTIVE STUDIES; TWIN STUDIES;

EID: 0033822153     PISSN: 00012815     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0039.2000.560301.x     Document Type: Article

References (27)

1. Diabetes mellitus - A geneticist's nightmare
2. Diabetes mellitus
3. Diabetes in identical twins: A study of 200 pairs
4. Meaning of concordance and discordance in estimation of penetrance and gene frequency
5. Extended HLA/complement allele haplotypes: Evidence for T/t-like complex in man
6. HLA-DR2, [HLA-B7, SC31, DR2], and [HLA-B8, SC01, DR3] haplotypes distinguish subjects with asthma from those with rhinitis only in ragweed pollen allergy
7. Extended major histocompatibility complex haplotypes in patients with gluten-sensitive enteropathy
8. An approach to the localization of the susceptibility gene for generalized myasthenia gravis by mapping recombinant ancestral haplotypes
9. Major histocompatibility complex susceptibility genes for dermatitis herpetiformis compared with those for gluten-sensitive enteropathy
10. Major histocompatibility complex haplotype studies in Ashkenazi Jewish patients with pemphigus vulgaris
11. Extended major histocompatibility complex haplotypes in type I diabetes mellitus
12. Evidence for HL-A-linked genes in 'juvenile' diabetes mellitus
13. The affected sib method. IV. Sib trios
14. A simple estimate of the general population frequency of the MHC susceptibility gene for autoimmune polygenic disease
15. The genetic analysis of HLA and disease association
16. BF types and the mode of inheritance of insulin-dependent diabetes mellitus
17. Linkage of pemphigus antibody to the major histocompatibility complex in healthy relatives of patients
18. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: An animal model of HLA-B27-associated human disorders
19. Class I-induced resistance to natural killing: Identification of nonpermissive residues in HLA-A2
20. Nonresponsiveness to hepatitis B vaccine in health care workers. Results of revaccination and genetic typings
21. Genetic prediction of nonresponse to hepatitis B vaccine
22. The immune response to hepatitis B vaccine in man: Inheritance patterns in families
23. Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes
24. Beta cell autoantibodies in infants and toddlers without IDDM relatives: Diabetes autoimmunity study in the young (DAISY)
25. Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland
26. Prospective analysis suggests susceptibility genes for deficiencies of IgA and several other immunoglobulins on the [HLA-B8, SC01, DR3] conserved extended haplotype
27. The [HLA-B18, F1C30, DR3] conserved extended haplotype carries a susceptibility gene for IgD deficiency