Genetic polymorphisms of CYP2D6, CYP1A1, GSTM1 and p53 genes in a unique Siberian population of Tundra Nentsi

Pharmacogenetics

Volumn 10, Issue 6, 2000, Pages 531-537

  Duzhak, T ^a   Mitrofanov, D ^a   Ostashevskii, V ^a   Gutkina, N ^a   Chasovnikova, O ^a   Posukh, O ^a   Osipova, L ^a   Lyakhovich, V V ^a  

^a INSTITUTE OF MOLECULAR BIOLOGY AND BIOPHYSICS   (Russian Federation)

Author keywords

Cytochrome P450; Gene polymorphism; Mongoloids; Tundra Nentsi; Unique isolates

Indexed keywords

CYTOCHROME P450 ISOENZYME; PROTEIN P53;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER SUSCEPTIBILITY; CAUCASIAN; CHILD; COMPARATIVE STUDY; ETHNIC DIFFERENCE; FEMALE; GENE FREQUENCY; GENE MUTATION; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MONGOLOID RACE; PHARMACOGENETICS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RUSSIAN FEDERATION;

ADOLESCENT; ADULT; AGED; BASE SEQUENCE; CHILD; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2D6; DNA PRIMERS; ETHNIC GROUPS; FEMALE; GENE FREQUENCY; GLUTATHIONE TRANSFERASE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; SIBERIA;

EID: 0033821405     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200008000-00006     Document Type: Article

References (20)

1. Genetic susceptibility to lung cancer with the special emphasis on CYP1A1 and GSTM1: A study on host factors in relation to age at onset, gender and histological cancer types
2. Is polymorphism maintained by natural selection?
3. Correlation between trans-stilbene oxide-glutathione conjugation activity and the deletion mutation in the glutathione S-transferase class mu gene detected by polymerase chain reaction
4. Debrisoquine/sparteine hydroxylation genotype and phenotype: Analysis of common mutations and alleles of CYP2D6 in European populations
5. Deletion of the entire cytochrome P450 CYP2D6 gene as a case of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism
6. Identification of the primary gene defect at the cytochrome P450 CYP2D locus
7. Genetic linkage of lung cancer-associated Msp I polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P4501A1 gene
8. High susceptibility to lung cancer analyzed in terms of combined genotypes of P4501A1 and mu-class glutathione S-transferase
9. Evolutionary pharmacogenetics of CYP2D6 in Ngawbe Guaymi of Panama
10. Polymorphism of mitochondrial DNA in population of North Selkups
11. Germ line polymorphisms of p53 and CYP1A1 genes involved in human lung cancer
12. Germ line mutation in exon 5 of the p53 gene in an extended cancer family
13. Genetic polymorphism of cytochrome P450 CYP2D6 in Zimbabwean population
14. Characteristics of Mongoloid populations and immunogenetics of various diseases based on the genetic markers of human immunoglobulins
15. CYP2D6 phenotype and genotype in a Canadian native Indian population
16. The gene pool of native inhabitants of the Samburg Tundra
17. Genetic-demographic analysis of the population of native inhabitants of the Samburg Tundra
18. Molecular basis of genetic variation in debrisoquin hydroxylation in Chinese subjects: Polymorphism in RFLP and DNA sequence of CYP2D6
19. Relationship between the GSTM1 polymorphism and susceptibility to bladder, breast and colon cancer