Environmental stimulation increases survival in mice transgenic for exon 1 of the Huntington's disease gene

Movement Disorders

Volumn 15, Issue 5, 2000, Pages 925-937

  Morita, Hiroshi ^a   Shindo, Masaomi ^b   Ikeda, Shu Ichi ^a   Yanagisawa, Nobuo ^c  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SHINSHU UNIVERSITY   (Japan)

^c NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

Behavior; Environmental stimulation; Huntington's disease; Mice; Neurodegeneration; Transgenic

Indexed keywords

TRINUCLEOTIDE;

AGE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAGE; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; EXON; FEEDING BEHAVIOR; FEMALE; GENE SEQUENCE; HEALTH STATUS; HUNTINGTON CHOREA; LIFE EXPECTANCY; MALE; MORTALITY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STIMULATION; SURVIVAL; SYMPTOMATOLOGY; TRANSGENIC MOUSE; TRINUCLEOTIDE REPEAT; WELLBEING;

ANALYSIS OF VARIANCE; ANIMAL; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEEDING BEHAVIOR; FEMALE; HUMAN; HUNTINGTON DISEASE; MALE; MICE; MICE, TRANSGENIC; PHENOTYPE; PHYSICAL STIMULATION; SUPPORT, NON-U.S. GOV'T; SURVIVAL ANALYSIS; TIME FACTORS;

EID: 0033819849     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8257(200009)15:5<925::AID-MDS1025>3.0.CO;2-Z     Document Type: Article

References (49)

1. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
2. Excitotoxic injury of the neostriatum: A model for Huntington's disease
3. Neurochemical and histologic characterisation of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid
4. Behavioral pathology induced by repeated systemic injections of 3-nitropropionic acid mimics the motoric symptoms of Huntington's disease
5. Systemic 3-nitropropionic acid: Behavioral deficits and striatal damage in adult rats
6. Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates
7. Prepulse inhibition in the rat is regulated by ventral and caudo-dorsal striatopallidal circuitry
8. Mitochondrial toxin 3-nitropropionic acid produces startle reflex abnormalities and striatal damage in rats that model some features of Huntington's disease
9. Chronic 3-nitropropionic acid treatment in baboons replicates the cognitive and motor deficits of Huntington's disease
10. Hyperactivity and hypoactivity in a rat model of Huntington's disease: The systemic 3-nitropropionic acid model
11. Quantifiable bradykinesia, gait abnormalities and Huntington's disease-like striatal lesions in rats chronically treated with 3-nitropropionic acid
12. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
13. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
14. Ultra-structural localization and progressive formation of neuropil aggregates in Huntington's disease transgenic mice
15. Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene
16. Altered neurotransmitter receptor expression in transgenic mouse models of Huntington's disease
17. Brain neurotransmitter deficits in mice transgenic for the Huntington's disease mutation
18. Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation
19. Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation
20. From neuronal inclusions to neurodegeneration: Neuropathological investigation of a transgenic mouse model of Huntington's disease
21. Brain damage, behavior, rehabilitation, recovery, and brain plasticity
22. Physical activity enhances spatial learning performance with an associated alteration in hippocampal protein kinase C activity in C57BL/6 and DBA/2 mice
23. Daily spontaneous running alters behavioral and neurochemical indexes of nigrostriatal function
24. Learning and memory in the autoimmune BXSB mouse: Effects of neocortical ectopias and environmental enrichment
25. Expression of neurotrophin-3 mRNA in the rat visual cortex and hippocampus is influenced by environmental conditions
26. Differential environmental modulations on locomotor activity, exploration and spatial behaviour in young and old rats
27. Effects of neonatal stimulation on later cognitive function and hippocampal nerve growth factor
28. Functional outcome in rats transferred to an enriched environment 15 days after focal brain ischemia
29. Environment influences functional outcome of cerebral infarction in rats
30. Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective
31. After reaching retirement age physical activity sustains cerebral perfusion and cognition
32. The impact of long-term exercise training on psychological function in older adults
33. The effect of aerobic training on the cognitive performance of elderly patients with senile dementia of Alzheimer type
34. Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the nun study
35. Risk factors for dementia in Parkinson's disease: Effect of education
36. Exercise and brain neurotrophins
37. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain
38. Physical exercise induces FGF-2 and its mRNA in the hippocampus
39. Spatial learning and physical activity contribute to the induction of fibroblast growth factor: Neural substrates for increased cognition associated with exercise
40. Environmental enrichment results in higher levels of nerve growth factor mRNA in the rat visual cortex and hippocampus
41. Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes
42. An increase in dendritic spine density on hippocampal CA1 pyramidal cells following spatial learning in adult rats suggests the formation of new synapses
43. Mechanism of altered synaptic strength due to experience: Relation to long-term potentiation
44. More hippocampal neurons in adult mice living in an enriched environment
45. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
46. Learning enhances adult neurogenesis in the hippocampal formation
47. Endurance training effects on striatal D2 dopamine receptor binding and striatal dopamine metabolite levels
48. The effects of exercise training on [3-H] spiperone binding in rat striatum