A beneficial aspect of a CB1 cannabinoid receptor antagonist: SR141716A is a potent inhibitor of macrophage infection by the intracellular pathogen Brucella suis

Journal of Leukocyte Biology

Volumn 67, Issue 3, 2000, Pages 335-344

  Gross, A ^a   Terraza, A ^a   Marchant, J ^a   Bouaboula, M ^a   Ouahrani Bettache, S ^a   Liautard, J P ^a   Casellas, P ^a   Dornand, J ^a  

^a INSERM   (France)

Author keywords

CP55,940; Gram negative bacteria; Marijuana; WIN 55212 2

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; CANNABINOID RECEPTOR ANTAGONIST; FORSKOLIN; REACTIVE OXYGEN METABOLITE; RIMONABANT;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; BRUCELLA SUIS; CONTROLLED STUDY; GRAM NEGATIVE BACTERIUM; HUMAN; HUMAN CELL; LEUKOCYTE; MACROPHAGE; MONOCYTE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL;

BACTERIA (MICROORGANISMS); BRUCELLA; BRUCELLA MELITENSIS BIOVAR SUIS; CANNABIS SATIVA; NEGIBACTERIA;

EID: 0033817453     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.67.3.335     Document Type: Article

References (55)

1. Cannabinoid receptors and immunity
2. Secondary immunity to Legionella pneumophila and Th1 activity are suppressed by delta-9-tetrahydrocannabinol injection
3. In vitro and in vivo suppressive effects of delta-9-tetrahydrocannabinol on interferon production by murine spleen cells
4. Drugs and Immunity: Cannabinoids and their role in decreased resistance to infectious disease
5. Marijuana components suppress induction and cytolytic functions of murine cytotoxic T cells in vivo and in vitro
6. 9-tetrahydrocannabinol, cytokines, and immunity to Legionella pneumophilia
7. Marijuana and immunity: Tetrahydrocannabinol mediated inhibition of lymphocyte blastogenesis
8. Marijuana inhibition of cytotoxic T lymphocyte activity
9. Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein coupled mechanism
10. Influence of marijuana components (THC and CBD) on human mononuclear cytokine secretion in vitro
11. 9-Tetrahydrocannabinol (THC), on the synthesis of tumor necrosis factor by human large granular lymphocytes
12. 9 Tetrahydrocannabinol inhibition of tumor necrosis factor-α: Suppression of post-translational events
13. Tetrahydrocannabinol treatment suppresses growth restriction of Legionella pneumophila in murine macrophage cultures
14. 9-Tetrahydrocannabinol (THC) modulates IL-1 bioactivity in human monocyte/macrophage cell lines
15. Cannabinoid enhance human B-cell growth at low nanomolar concentrations
16. Identification of a functionally relevant cannabinoid receptor on mouse spleen cells, that is involved in cannabinoid-mediated immune modulation
17. Molecular characterization of a peripheral receptor for cannabinoids
18. Localization of cannabinoid receptors and non-saturable high density cannabinoid binding sites in peripheral tissue of the rat: Implications for receptor-mediated immunomodulation by cannabinoids
19. Cannabinoid-receptor expression in human leukocytes
20. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
21. Molecular aspects of cannabinoid receptors
22. Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor
23. Regulation of immune functions in rat splenocytes after acute and chronic in vivo treatment with CP-55,940, a synthetic cannabinoid compound
24. 1 cannabinoid receptors in haemorrhagic shock
25. Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes
26. SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
27. SR144528, the first potent and selective antagonist of the CB2 cannabinoid receptor
28. Live Brucella spp. fail to induce tumor necrosis factor alpha excretion upon infection of U937-derived phagocytes
29. Brucella species release a specific, protease-sensitive, inhibitor of TNF-α expression, active on human macrophage-like cells
30. Expression and bactericidal activity of nitric oxide synthase in Brucella-suis infected murine macrophages
31. pBBR1-GFP: A broad-host-range vector for prokaryotic promoter studies
32. 3-differentiated U937 cells
33. A selective inverse agonist for central cannabinoid receptor inhibits protein kinase activation stimulated by insulin or insulin-like growth factor 1
34. Nitric oxide production in human macrophagic cells phagocytizing opsonised zymosan: Direct characterization by measurement of the luminol dependent chemiluminescence
35. 9-tetrahydrocannabinol is mediated through the inhibition of nuclear factor-κB/Rel activation
36. SR 144528, an antagonist for the peripheral cannabinoid receptor that behaves as an inverse agonist
37. Regulation of the cAMP cascade, gene expression and immune function by cannabinoid receptors
38. The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells
39. Interaction between professional phagocytes and Brucella spp
40. 2 receptors
41. Expression of cannabinoid receptor mRNA in murine and human leukocytes
42. Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 knockout mice
43. 9-tetrahydrocannabinol-induced responses and apparent agonist activity
44. Modulation of CB1 cannabinoid receptor functions after a long-term exposure to agonist in the Chinese hamster ovary cell expression system
45. Macrophage response to microbial pathogens: Modulation of the expression of adhesion, CD14, and MHC class II molecules by viruses, bacteria, protozoa, and fungi
46. CD14+ monocytes, CD14+CD16+ subset and soluble CD14 as biological markers of inflammatory systemic diseases and monitoring immunosuppressive therapy
47. Involvement of Gi in the inhibition of adenylate cyclase by cannabimetic drugs
48. Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells
49. Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1
50. Stimulation of cannabinoid receptor CB1 induces Krox-24 expression in human astrocytoma cells
51. Dialogue between the CNS and the immune system in lymphoid organs
52. Cannabinoid receptor proteins are increased in Jurkat, human T-cell line after mitogen activation
53. Effects of the cannabinoid CB1 receptor antagonist SR141716A on the behavior of pigeons and rats
54. Acidification of phagosome containing Salmonella typhimurium in murine macrophages
55. Early acidification of phagosomes containing Brucella suis is essential for intracellular survival in murine macrophages