Myristoylation-dependent N-terminal cleavage of the myristoylated alanine-rich C kinase substrate (MARCKS) by cellular extracts

Biochimie

Volumn 82, Issue 8, 2000, Pages 705-715

  Braun, Thomas ^a   McIlhinney, R A Jeffrey ^b   Vergères, Guy ^a,c  

^a UNIVERSITY OF BASEL   (Switzerland)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c ZLB Zentrallaboratorium   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN EXTRACT; CELL EXTRACT; LYSINE; MARCKS PROTEIN; PROTEINASE; THREONINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BRAIN CELL; CATTLE; CELL ACTIVITY; ESCHERICHIA COLI; HUMAN; MACROPHAGE FUNCTION; MEMBRANE BINDING; MOLECULAR RECOGNITION; MOUSE; MYRISTYLATION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN MODIFICATION;

EID: 0033814234     PISSN: 03009084     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-9084(00)01154-8     Document Type: Article

References (49)

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5. MARCKS deficiency in mice leads to abnormal brain development and perinatal death
6. Neural tube defects and abnormal brain development in F52-deficient mice
7. Disruption of the MacMARCKS gene prevents cranial neural tube closure and results in anencephaly
8. Activation of protein kinase C results in the displacement of its myristoylated, alanine-rich substrate from punctate structures in macrophage filopodia
9. MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin
10. Signal transduction and the actin cytoskeleton: The roles of MARCKS and profilin
11. Calmodulin and protein kinase C cross-talk: The MARCKS protein is an actin filament and plasma membrane cross-linking protein regulated by protein kinase C phosphorylation and by calmodulin
12. Protein kinase C regulates MARCKS cycling between the plasma membrane and lysosomes in fibroblasts
13. A role for MARCKS, the alpha isozyme of protein kinase C and myosin I in zymosan phagocytosis by macrophages
14. Overexpression of the myristoylated alanine-rich C-kinase substrate in Rat1 cells increases sensitivity to calmodulin antagonists
15. Myristoylated alanine-rich C kinase substrate (MARCKS) produces reversible inhibition of phospholipase C by sequestering phosphatidylinositol 4,5-bisphosphate in lateral domains
16. Phosphorylation and associated translocation of the 87-kDa protein, a major protein kinase C substrate, in isolated nerve terminals
17. Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane
18. Expression of the major protein kinase C substrate, the acidic 80- kilodalton myristoylated alanine-rich C kinase substrate, increases sharply when Swiss 3T3 cells move out of cycle and enter G0
19. Distribution of the protein kinase C substrates MARCKS and MRP in the postnatal developing rat brain
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23. Poly(ADP-ribose) modulates the properties of MARCKS proteins
24. Demyristoylation of the major substrate of protein kinase C (MARCKS) by the cytoplasmic fraction of brain synaptosomes
25. Decreased susceptibility of a 70-kDa protein to cathepsin L after phosphorylation by protein kinase C
26. Protein kinase C-mediated phosphorylation of the myristoylated alanine-rich C-kinase substrate protects it from specific proteolytic cleavage
27. Identification and characterization of cathepsin B as the cellular MARCKS cleaving enzyme
28. MARCKS-related protein (MRP) is a substrate for the Leishmania major surface protease leishmanolysin (gp63)
29. Down-regulation of MARCKS-related protein (MRP) in macrophages infected with Leishmania
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31. The myristoyl moiety of myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein is embedded in the membrane
32. Protein kinase C-mediated phosphorylation and calmodulin binding of recombinant myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein
33. Characterization of a polyhistidine-tagged form of human myristoyl-CoA: Protein N-myristoyltransferase produced in Escherichia coli
34. Membrane targeting via protein N-myristoylation
35. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
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37. Phosphate analysis
38. Protein measurement with the Folin phenol reagent
39. The biology and enzymology of eukaryotic protein acylation
40. Myristoylation does not modulate the properties of MARCKS-related protein (MRP) in solution
41. Evidence for a non-myristoylated pool of the 80 kDa protein kinase C substrate of rat brain
42. Analysis of the immunoglobulin A protease gene of Streptococcus sanguis
43. A novel endopeptidase with a strict specificity for threonine residues at the P1'position
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45. Isolation of the non-myristoylated form of a major substrate of protein kinase C (MARCKS) from bovine brain
46. Specific proteolytic cleavage of the myristoylated alanine-rich C kinase substrate between Asn 147 and Glu 148 also occurs in brain
47. Phosphorylation reverses the membrane association of peptides that correspond to the basic domains of MARCKS and neuromodulin
48. Phosphorylation, high ionic strength, and calmodulin reverse the binding of MARCKS to phospholipid vesicles