Anisotropic effects of sodium channel blockers on the wavelength for ventricular excitation in dogs

Japanese Circulation Journal

Volumn 64, Issue 9, 2000, Pages 689-694

  Watanabe, T ^a   Yamaki, M ^a   Tachibana, H ^a   Yamauchi, S ^a   Kubota, I ^a   Tomoike, H ^a  

^a YAMAGATA UNIVERSITY   (Japan)

Author keywords

Anisotropy; Proarrhythmia; Wavelength

Indexed keywords

DISOPYRAMIDE; FLECAINIDE; LIDOCAINE; SODIUM CHANNEL AFFECTING AGENT;

ANIMAL EXPERIMENT; ARRHYTHMOGENESIS; ARTICLE; CONTROLLED STUDY; DOG; DRUG EFFECT; ELECTROCARDIOGRAM; HEART ARRHYTHMIA; HEART VENTRICLE ARRHYTHMIA; INTRACORONARY INFUSION; NONHUMAN; SODIUM CHANNEL;

ACTION POTENTIALS; ANIMAL; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIA; DISOPYRAMIDE; DOGS; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGY; FLECAINIDE; HEART CONDUCTION SYSTEM; HEART VENTRICLE; LIDOCAINE; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SUPPORT, NON-U.S. GOV'T; TACHYCARDIA, VENTRICULAR; VENTRICULAR FIBRILLATION;

EID: 0033813435     PISSN: 00471828     EISSN: None     Source Type: Journal    
DOI: 10.1253/jcj.64.689     Document Type: Article

References (33)

1. Reentrant Mechaisms Underlying Atrial Fibrillation
2. Reentrant and focal arrhythmias in low potassium in isolated rabbit atrium
3. Length of excitation wave and susceptibility to reentrant atrial arrhythmias in normal conscious dogs
4. Electrophysiological effects of myocardial ischaemia: Relationship with early ventricular arrhythmias
5. Effects of procainamide and dl-sotalol on the changes of atrial electrophysiology induced by high current stimulation
6. Effects of adenosine on wavelength of premature atrial complexes in patients without structural heart disease
7. The discontinuous nature of propagation in normal canine cardiac muscle: Evidence for recurrent discontinuities of intracellular resistance that affect the membrane currents
8. The functional role of structural complexities in the propagation of depolarization in the atrium of the dog: Cardiac conduction disturbances due to discontinuities of effective axial resistivity
9. Anisotropic conduction and functional dissociation of ischemic tissue during reentrant ventricular tachycardia in canine myocardial infarction
10. Antiarrhythmic drug classification: New science and practical applications
11. Proarrhythmic response to sodium channel blockade: Theoretical model and numerical experiments
12. Kinetics of onset of rate-dependent effects of Class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification
13. Relation between activation sequence fluctuation and arrhythmogenicity in sodium-channel blockades
14. Effects of activation sequence on monophasic action potential configuration in the dog
15. Electrophysiologic effects of sodium channel blockade on anisotropic conduction and conduction block in canine myocardium: Preferential slowing of longitudinal conduction by flecainide versus disopyramide or lidocaine
16. + channel on ECG ST segment elevation during a bout of myocardial ischemia: A study on epicardial mapping in dogs
17. Discordant S-T alternans contributes to formation of reentry: A possible mechanism of reperfusion arrhythmia
18. Intracoronary flecainide induces ST alternans and reentrant arrhythmia on intact canine heart: A role of 4-aminopyridine-sensitive current
19. Relation between recovery sequence estimated from body surface potentials and T wave shape in patients with negative T waves and normal subjects
20. Correlation between in vivo transmembrane action potential durations and activation-recovery intervals from electrograms: Effects of interventions that alter repolarization time
21. Correlation between refractory periods and activation-recovery intervals from electrograms: Effects of rate and adrenergic interventions
22. Cycle length dependence of human action potential duration in vivo: Effects of single extrastimuli, sudden sustained rate acceleration and deceleration, and different steady-state frequencies
23. Reentrant tachycardia in a thin layer of ventricular subepicardium: Effects of d-sotalol and lidocaine
24. Effect of acute ventricular dilatation on fibrillation thresholds in the isolated rabbit heart
25. Interaction of hypokalemia and ventricular dilatation in isolated rabbit hearts
26. Comparative mechanisms of antiarrhythmic drug action in experimental atrial fibrillation: Importance of use-dependent effects on refractoriness
27. Idiopathic atrial fibrillation in dogs: Electrophysiologic determinants and mechanisms of antiarrhythmic action of flecainide
28. Mechanism of interruption of atrial flutter by moricizine: Electrophysiological and multiplexing studies in the canine sterile pericarditis model of atrial flutter
29. Optical mapping in a new guinea pig model of ventricular tachycardia reveals mechanisms for multiple wavelengths in a single reentrant circuit
30. Preliminary report: Effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction
31. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation
32. Class I antiarrhythmic drugs: Quinidine, procainamide, disopyramide, lidocaine, mexiletine, tocainide, phenytoin, moricizine, flecainide, propafenone
33. Propagating depolarization in anisotropic human and canine cardiac muscle; apparent directional differences in membrane capacitance: A simplified model for selective directional effects of modifying the sodium conductance on Vmax, tau foot, and the propagation safety factor