Identification of Actinobacillus pleuropneumoniae virulence genes using signature-tagged mutagenesis in a swine infection model

Microbial Pathogenesis

Volumn 29, Issue 1, 2000, Pages 39-51

  Fuller, Troy E ^a   Martin, Stephen ^a   Teel, Janet F ^a   Alaniz, Glenn R ^a   Kennedy, Michael J ^a   Lowery, David E ^a  

^a PFIZER INC   (United States)

Author keywords

Actinobacillus pleuropneumoniae; Attenuated; Signature tagged mutagenesis (STM); Vaccine; Virulence

Indexed keywords

ACTINOBACILLUS PLEUROPNEUMONIAE VACCINE; BACTERIAL VACCINE; UNCLASSIFIED DRUG;

ACTINOBACILLUS PLEUROPNEUMONIAE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; BACTERIUM MUTANT; BRONCHOPNEUMONIA; CONTROLLED STUDY; GENE INSERTION; MUTAGENESIS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SWINE DISEASE;

ACTINOBACILLUS PLEUROPNEUMONIAE;

EID: 0033813409     PISSN: 08824010     EISSN: None     Source Type: Journal    
DOI: 10.1006/mpat.2000.0364     Document Type: Article

References (48)

1. Actinobacillus and Haemophilus
2. Serological and immmunological studies of pleuropneumonia of swine caused by Haemophilus parahaemolyticus
3. Haemophilus parahaemolyticus serotypes: Pathogenicity and cross immunity
4. Haemophilus pleuropneumoniae serotypes - Cross protection experiments
5. Vaccination and protection of pigs against pleuropneumonia with a vaccine strain of Actinobacillus pleuropneumoniae produced by Site-specific mutagenesis of the ApxII operon
6. Safety, stability, and efficacy of noncapsulated mutants of Actinobacillus pleuro, pneumoniae for use in live vaccines
7. Identification of in vivo induced genes in Actinobacillus pleuropneumoniae
8. Simultaneous identification of bacterial virulence genes by negative selection
9. Identification of Pasteurella multocida virulence genes in a septicemic mouse model using signature-tagged mutagenesis
10. Transposon mutagenesis in Actinobacillus pleuropneumoniae with a Tn10 derivative
11. Salmonella typhimurium responses to a bactericidal protein from human neutrophils
12. Sequence, genetic analysis, and expression of Actinobacillus pleuropneumoniae transferrin receptor genes
13. Functions of potA and potD proteins in spermidine-preferential uptake system in Escherichia coli
14. Genetic and immunological analyses of a 38kDa surface-exposed lipoprotein of Pasteurella haemolytica A1
15. Large-scale identification of virulence genes from Streptococcus pneumoniae
16. The major outer membrane protein of Haemophilus ducreyi consists of two OmpA homologs
17. Molecular cloning of the Pasteurella haemolytica pomA gene and identification of bovine antibodies against PomA surface domains
18. Role of fimbriae expressed by nontypeable Haemophilus influenzae in pathogenesis of and protection against otitis media and relatedness of the fimbrin subunit to outer membrane protein A
19. Selective adherence of non-typeable Haemophilus influenzae (NTHi) to mucus or epithelial cells in the chinchilla eustachian tube and middle ear
20. Binding between outer membrane proteins of nontypeable Haemophilus influenzae and human nasopharyngeal mucin
21. Adhesin-receptor interactions in Pasteurellaceae
22. Escherichia coli and other species of the Enterobacteriaceae encode a protein similar to the family of Mip-like FK506-binding proteins
23. Decreased intracellular survival of an fkpA mutant of Salmonella typhimurium Copenhagen
24. DNA sequence of mip, a Legionella pneumophila gene associated with macrophage infectivity
25. A Legionella pneumophila gene encoding a species-specific surface protein potentiates initiation of intracellular infection
26. A mutation in the mip gene results in an attenuation of Legionella pneumophilia virulence
27. The Escherichia coli trigger factor
28. A role for trigger factor and an rgg-like regulator in the transcription, secretion and processing of the cysteine proteinase of Streptococcus pyogenes
29. vacB, a novel chromosomal gene required for expression of virulence genes on the large plasmid of Shigella flexneri
30. Identification of Salmonella typhimurium genes required for colonization of the chicken alimentary tract and for virulence in newly hatched chicks
31. The heat-shock proteins
32. Induction of Yersinia enterocolitica stress proteins by phagocytosis with macrophage
33. Listeria monocytogenes can grow in macrophages without the aid of proteins induced by environmental stresses
34. Participation of the molecular chaperone DnaK in intracellular growth of Brucella suis within U937-derived phagocytes
35. Role of DnaK in in vitro and in vivo expression of virulence factors of Vibrio cholerae
36. Identification and characterization of a new Escherichia coli gene that is a dosage-dependent suppressor of a dnaK deletion mutation
37. Novel species of tRNA
38. A soluble enzyme from Escherichia coli which catalyzes the transfer of leucine and phenylalanine from tRNA to acceptor proteins
39. Mutation of the miaA gene of Agrobacterium tumefaciens results in reduced vir gene expression
40. Temperature regulation of Shigella virulence: Identification of the repressor gene virR, an analogue of hns, and partial complementation by tyrosyl transfer RNA (tRNA1 (Tyr))
41. Multiple loci of Pseudomonas syringae pv. syringae are involved in pathogenicity on bean: Restoration of one lesion-deficient mutant requires two tRNA genes
42. tRNA genes and pathogenicity islands: Influence on virulence and metabolic properties of uropathogenic Escherichia coli
43. The leuX-encoded tRNA5(Leu) but not the pathogenicity islands I and II influence the survival of the uropathogenic Escherichia coli strain 536 in CD-1 mouse bladder mucus in the stationary phase
44. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd
45. The complete genome sequence of Escherichia coli K-12
46. Identification of a putative Salmonella enterica serotype typhimurium host range factor with homology to IpaH and YopM by signature-tagged mutagenesis
47. Preparation of genomic DNA from bacteria