Estimation following extension of a study on the basis of conditional power

Journal of Biopharmaceutical Statistics

Volumn 10, Issue 2, 2000, Pages 131-144

  Denne, J S ^a  

^a DE MONTFORT UNIVERSITY   (United Kingdom)

Author keywords

Bias; Clinical trials; Conditional power; Early stopping; Interim monitoring; Internal pilot; Resizing; Sample size; Two stage procedure

Indexed keywords

COLESTYRAMINE; PLACEBO;

BIOSTATISTICS; CLINICAL RESEARCH; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; HUMAN; HYPERLIPIDEMIA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; REVIEW; SAMPLING; STATISTICAL PARAMETERS; TREATMENT OUTCOME;

ALGORITHMS; ANTICHOLESTEREMIC AGENTS; BIAS (EPIDEMIOLOGY); CHOLESTYRAMINE; CORONARY DISEASE; DATA INTERPRETATION, STATISTICAL; RESEARCH DESIGN; SAMPLE SIZE;

EID: 0033813326     PISSN: 10543406     EISSN: None     Source Type: Journal    
DOI: 10.1081/BIP-100101018     Document Type: Review

References (9)

1. Designed extension of studies based on conditional power
2. The role of internal pilot-studies in increasing the efficiency of clinical trials
3. Planning and revising the sample size for a trial
4. Estimating the sample size for a t-test using an internal pilot
5. Internal pilot studies I: Type I error rate of the naive t-test
6. Sequential estimation for 2-stage and 3-stage clinical-trials
7. Statistical approaches to interim monitoring of medical trials: A review and commentary
8. Point and interval estimation following a sequential clinical trial