Insulin-like growth factor I prevents the development of sensitivity to kainate neurotoxicity in cerebellar granule cells

Journal of Neurochemistry

Volumn 75, Issue 4, 2000, Pages 1548-1556

  Leski, Michael L ^a   Valentine, Stacey L ^a   Baer, Jesse D ^a   Coyle, Joseph T ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MCLEAN HOSPITAL   (United States)

Author keywords

Cerebellar granule cells; Insulin like growth factor I; Kainate; Neurotoxicity; p70 S6 kinase; Phosphatidylinositol 3 kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BRAIN DERIVED NEUROTROPHIC FACTOR; KAINIC ACID; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NERVE GROWTH FACTOR; NEUROTROPHIN 3; NEUROTROPHIN 4; PHOSPHATIDYLINOSITOL 3 KINASE; RAPAMYCIN; RECEPTOR; S6 KINASE; SOMATOMEDIN C; SPIDER VENOM; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CEREBELLUM; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GRANULE CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; CULTURE MEDIA, SERUM-FREE; DOSE-RESPONSE RELATIONSHIP, DRUG; INSULIN; INSULIN-LIKE GROWTH FACTOR I; KAINIC ACID; NEUROPROTECTIVE AGENTS; NEUROTOXINS; NIFEDIPINE; RATS; RECEPTORS, AMPA; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; SPIDER VENOMS;

ANIMALIA; ARANEAE;

EID: 0033812747     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0751548.x     Document Type: Article

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