Downregulation of the CCR5 β-chemokine receptor and inhibition of HIV-1 infection by stable VA1-ribozyme chimeric transcripts

Antisense and Nucleic Acid Drug Development

Volumn 10, Issue 4, 2000, Pages 251-261

  Cagnon, L ^a   Rossi, J J ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; RIBOZYME;

ARTICLE; CHIMERA; ENZYME STRUCTURE; GENE THERAPY; HOMOZYGOTE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; RECEPTOR INTRINSIC ACTIVITY; SEQUENCE HOMOLOGY; VIRUS STRAIN;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0033811703     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/108729000421439     Document Type: Article

References (32)

1. CC CKR5: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion co-factor for macrophage-tropic HIV-1
2. Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease
3. The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localization
4. Facilitation of hammerhead ribozyme catalysis by the nucleocapsid protein of HIV-1 and the heterogeneous nuclear ribonucleoprotein A1
5. Protection of a T-cell line from human immunodeficiency virus replication by the stable expression of a short antisense RNA sequence carried by a shuttle RNA molecule
6. Inhibition of HIV type 1 Ba-L replication by MIP-1alpha, MIP-1beta, and RANTES in macrophages
7. The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection
8. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene
9. Identification of a major coreceptor for primary isolates of HIV-1
10. The binding of double-stranded RNA and adenovirus VA1 RNA to the interferon-induced protein kinase
11. Beta-chemokines and protection from HIV type 1 disease
12. Binding of the adenovirus VA1 RNA to the interferon-induced 68-kDa protein kinase correlates with function
13. Expression of small, therapeutic RNAs in human cell nuclei
14. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression
15. Adenovirus VA1 RNA complexes with the 68 000 Mr protein kinase to regulate its autophosphorylation and activity
16. Packaging system for rapid production of murine leukemia virus vectors with variable tropism
17. Translation inhibition by an mRNA coding region secondary structure is determined by its proximity to the AUG initiation codon
18. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply exosed individuals to HIV-1 infection
19. Growth of macrophage-tropic and primary human immunodeficiency virus type 1 (HIV-1) isolates in a unique CD4+ T-cell clone (PM1): Failure to downregulate CD4 and to interfere with cell line-tropic HIV-1
20. CCR5-delta 32 gene deletion in HIV-1 infected patients
21. Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production
22. Advanced mammalian gene transfer: High titer retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
23. Inhibition of HIV-1 infection by the beta-chemokine MDC
24. The HIV type 1 coreceptor CCR5 and its role in viral transmission and disease progression
25. An alternate method for synthesis of double-stranded DNA segments
26. Sequence requirements of the hammerhead RNA self-cleavage reaction
27. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
28. Cytoplasmic asembly of snRNP particles from stored proteins and newly transcribed snRNA's in L929 mouse fibroblasts
29. Adenovirus VA1-RNA regulates gene expression by controlling stability of ribosome-bound RNAs
30. A novel effect of adenovirus VA RNA1 on cytoplasmic mRNA abundance
31. Chemokines: Understanding their role in T-lymphocyte biology