Oral administration of inducible nitric oxide synthase inhibitors reduces nitric oxide synthesis but has no effect on the severity of experimental colitis

Scandinavian Journal of Gastroenterology

Volumn 35, Issue 8, 2000, Pages 832-838

  Armstrong, A M ^a   Campbell, G R ^a   Gannon, C ^a   Kirk, S J ^a   Gardiner, K R ^a  

^a Institute of Clinical Sciences B   (United Kingdom)

Author keywords

1 nitroso arginine methyl ester; Aminoguanidine; Colitis; Nitric oxide; Trinitrobenzene sulfonic acid

Indexed keywords

AMINOGUANIDINE; DRINKING WATER; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; TRINITROBENZENESULFONIC ACID;

ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BODY WEIGHT; COLITIS; COLON DISEASE; COLON MUCOSA; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME INHIBITION; EXPERIMENTAL MODEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME;

EID: 0033811660     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.1080/003655200750023200     Document Type: Article

References (31)

1. Brain nitric oxide is a haem protein
2. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
3. Cloning and characterisation of inducible nitric oxide synthase from mouse macrophages
4. Purification of a distinctive form of endotoxin induced nitric oxide synthase from rat liver
5. Nitric oxide physiology pathophysiology and pharmacology
6. Nitric oxide in physiology and pathology
7. Detectable colonic nitrate levels in ulcerative colitis-mucosal or bacterial dysfunction?
8. Increased nitric oxide synthesis in ulcerative colitis
9. Are serum concentrations of nitric oxide metabolites useful for predicting the clinical outcome of severe ulcerative colitis?
10. Nitric oxide release in response to gut injury
11. Induction of nitric oxide synthase in rat intestine and its association with tissue injury
12. Manipulation of the arginine nitric oxide pathway in experimental colitis
13. Experimental colitis is inhibited by inhibition of nitric oxide synthase activity
14. The selective beneficial effects of nitric oxide inhibition in experimental colitis
15. Isothioureas: Potent inhibitors of nitric oxide synthases with variable isoform selectivity
16. Potent and selective inhibition of nitric oxide synthases. Inhibition by non-amino acid isothioureas
17. Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease
18. Hapten induced model of chronic inflammation and ulceration in the rat colon
19. Effects of chronic nitric oxide synthase inhibition on TNB induced colitis in rats
20. Induction of nitric oxide synthase and concomitant suppression of superoxide dismutase in experimental colitis in rats
21. The effect of NOS inhibitors on TNB colitis-a comparative study
22. Differential time dependent effects of nitric oxide synthase inhibition on colonic inflammation induced by trinitrobenzenesulfonic acid in rats
23. The effect of aminoguanidine, an iNOS selective NOS inhibitor, on TNB colitis
24. Apparent hydroxyl radical production from peroxynitrite: Implications for endothelial cell injury from nitric oxide and superoxide
25. Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide
26. Peroxynitrite induced experimental colitis-a new model indicating the contribution of the NO radical to the pathogenesis of colonic inflammation
27. Nitric oxide: An overview
28. Possible involvement of cGMP in the control of cultured mouse cells
29. Actions of nitric oxide on the acute gastrointestinal damage induced by PAF in rats
30. Nitric oxide: An endogenous modulator of leukocyte adhesion
31. Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation