Entamoeba invadens: Protein kinase C inhibitors block the growth and encystation

Experimental Parasitology

Volumn 95, Issue 4, 2000, Pages 288-290

  Makioka, Asao ^a   Kumagai, Masahiro ^a   Ohtomo, Hiroshi ^a   Kobayashi, Seiki ^b   Takeuchi, Tsutomu ^b  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

DMSO, dimethyl sulfoxide; Encystation; Entamoeba invadens; PKC, protein kinase C; PMA, phorbol 12 myristate 13 acetate; Protozoa; Signal transduction

Indexed keywords

CALPHOSTIN C; CHELERYTHRINE; PROTEIN KINASE C INHIBITOR; SPHINGOSINE; STAUROSPORINE;

ARTICLE; CONCENTRATION RESPONSE; ENTAMOEBA INVADENS; ENZYME INHIBITOR COMPLEX; GROWTH INHIBITION; INHIBITION KINETICS; LIFE CYCLE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ENTAMOEBA INVADENS; PROTOZOA;

EID: 0033810056     PISSN: 00144894     EISSN: None     Source Type: Journal    
DOI: 10.1006/expr.2000.4538     Document Type: Article

References (11)

1. A new medium for the axenic cultivation of Entaoemeba histolytica and other Entamoeba
2. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets
3. Chelerythrine is a potent and specific inhibitor of protein kinase C
4. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C
5. Encystation in Entamoeba invadens
6. Studies and perspectives of protein kinase C
7. Staurosporine, K-252 and UCN-01: Potent but nonspecific inhibitors of protein kinases
8. Identification of a developmentally regulated transcript expressed during encystation of Entamoeba invadens
9. Entamoeba histolytica: PKC transduction pathway activation in the trophozoite-fibronectin interaction
10. ++ dependent protein kinase
11. Phorbol esters specifically enhance the cytolytic activity of Entamoeba histolytica