Suppressive effect of rebamipide, an antiulcer agent, against activation of human neutrophils exposed to formyl-methionyl-leucyl-phenylalanine

Histology and Histopathology

Volumn 15, Issue 4, 2000, Pages 1067-1076

  Kobayashi, T ^a   Zinchuk, V S ^a   Garcia Del Saz, E ^a   Jiang, F ^a   Yamasaki, Y ^a   Kataoka, S ^a   Okada, T ^a   Tsunawaki, S ^a   Seguchi, H ^a  

^a KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

Alkaline phosphatase; CD16; Chemotaxis; NADPH oxidase; Rebamipide

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM ION; CD16 ANTIGEN; FORMYLMETHIONYLLEUCYLPHENYLALANINE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; REBAMIPIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; DRUG INHIBITION; DRUG MECHANISM; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; LEUKOCYTE ACTIVATION; NEUTROPHIL CHEMOTAXIS; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; ULCER;

ALANINE; ALKALINE PHOSPHATASE; ANTI-ULCER AGENTS; CALCIUM; CELL MOVEMENT; CHEMOTACTIC FACTORS; CHEMOTAXIS; FLOW CYTOMETRY; HUMANS; INDICATORS AND REAGENTS; MACROPHAGE ACTIVATION; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NADPH OXIDASE; NEUTROPHILS; QUINOLONES; RECEPTORS, IGG; SECRETORY VESICLES; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 0033809602     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Molecular analysis of suppression of interleukin-8 production by rebamipide in Helicobacter pylori-stimulated gastric cancer cell lines
2. NADPH oxidase: An update
3. Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases
4. Chemoattractant signaling and leukocyte activation
5. Granules of the human neutrophilic polymorphonuclear leukocytes
6. Identification of a highly mobilizable subset of human neutrophil intracellular vesicles that contains tetranectin and latent alkaline phosphatase
7. Human neutrophil granules and secretory vesicles
8. The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-coupled receptors
9. Evidence for small intracellular vesicles in human blood phagocytes containing cytochrome b558 and the adhesion molecule CD11b/CD18
10. Calcium signaling
11. Nonopsonic activation of neutrophils by Helicobacter pylori is inhibited by rebamipide
12. A reference procedure to study chemiluminescence induced in polymorphonuclear leukocytes by Neisseria meningitidis
13. Preventive effect of rebamipide on gastric mucosal cell damage evoked by activation of formyl-methionyl-leucyl-phenylalanine receptors of rabbit neutrophils
14. A novel intracellular compartment with unusual secretory properties in human neutrophils
15. Novel insight into current models of NADPH oxidase regulation, assembly and localization in human polymorphonuclear leukocytes
16. Identification of intracellular sites of superoxide production in stimulated neutrophils
17. Detection of oxidant producing-sites in glutaraldehyde-fixed human neutrophils and eosinophils stimulated with phorbol myristate acetate
18. Actin-binding membrane proteins identified by F-actin blot overlays
19. Gastric mucosal injury and repair: Effect of aging
20. The microestimation of succinate and the extinction coefficient of cytochrome c
21. Superoxide dismutase: An enzymatic function for erythrocuprein (hemocuprein)
22. Actin polymerization induces FcgammaRIII (CD16) from human neutrophils
23. Chemotaxis of chinese hamster ovary cells expressing the human neutrophil formyl peptide receptor: Role of signal transduction molecules and α5Ab1 integrin
24. Involvement of CD44 and the cytoskeletal linker protein ankyrin in human neutrophil bacterial phagocytosis
25. Rebamipide prevents indomethacin-induced gastric mucosal lesion formation by inhibiting activation of neutrophils in rats
26. IFN-gamma-induced iNOS mRNA expression is inhibited by rebamipide in murine macrophage RAW264.7 cells
27. Effect of rebamipide, a novel anti-ulcer agent, on acute gastric mucosal injury induced by ischemia-reperfusion in rats
28. Hydroxyl radical scavenging by rebamipide and related compounds: Electron paramagnetic resonance study
29. Studies and perspectives of protein kinase C
30. Antiulcer mechanism of action of rebamipide, a novel antiulcer compound, on diethyldithiocarbamate-induced antral gastric ulcers in rats
31. A new flow cytometric assay for the evaluation of phagocytes and the oxidative burst in whole blood
32. The microanatomy of calcium stores in human neutrophils: Relationship of structure to function
33. A simple method for ultrastructural enzyme cytochemistry on small volumes and numbers of isolated cells
34. The NADPH oxidase complex of phagocytic leukocytes: A biochemical and cytochemical view
35. Protection by rebamipide against acetic acid-induced colitis in rats: Relationship with its antioxidative activity
36. Control of exocytosis in early neutrophil activation
37. Role of neutrophils in hemorrhagic shock-induced gastric mucosal injury in the rat
38. Effect of rebamipide on the glycosaminoglycan content of the ulcerated rat stomach
39. A low-viscosity epoxy resin embedding medium for electron microscopy
40. The gastro-duodenal epithelium in peptic ulceration
41. Protective effect of rebamipide against ammonia-induced gastric mucosal lesions
42. Rebamipide treatment activates epidermal growth factor and its receptor expression in normal and ulcerated gastric mucosa in rats: One mechanism for its ulcer healing action?
43. Cerium-based histochemical demonstration of oxidative stress in taurocholate-induced acute pancreatitis in rates: A confocal laser scanning microscopic study
44. Role of neutrophils in a rat model of gastric ulcer recurrence caused by interleukin-1β
45. Transient elevations of cytosolic free calcium retard subsequent apoptosis in neutrophils in vivo
46. Ultra-high-resolution scanning electron microscopy of the sarcoplasmic reticulum of the rat atrial myocardial cells
47. Influence of rebamipide on indometacin-induced gastric hemorrhage in rats under restraint stress
48. Free radical scavenging activity of the novel anti-ulcer agent rebamipide studied by electron spin resonance
49. Rebamipide protects against activation of neutrophils by Helicobacter pylori