Three leucine-rich sequences and the N-terminal region of double-stranded RNA-activated protein kinase (PKR) are responsible for its cytoplasmic localization

Journal of Biochemistry

Volumn 128, Issue 3, 2000, Pages 471-476

  Takizawa, Takenori ^a   Tatematsu, Chizuru ^a   Watanabe, Masami ^b   Yoshida, Minoru ^c   Nakajima, Katsuhisa ^d  

^a INSTITUTE FOR DEVELOPMENTAL RESEARCH   (Japan)

^b Institute for Developmental Researchm Aichi Human Service Center   (Nigeria)

^c UNIVERSITY OF TOKYO   (Japan)

^d NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

EGFP; Leptomycin B; NES; NLS; PKR

Indexed keywords

DOUBLE STRANDED RNA; PROTEIN KINASE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CYTOPLASM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN LOCALIZATION;

ANIMALIA;

EID: 0033809167     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a022776     Document Type: Article

References (33)

1. The double stranded RNA-activated protein kinase induced by interferon: Dsrna-PK
2. Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon
3. The role of the dsRNA-activated kinase, PKR, in signal transduction
4. The eIF-2α protein kinases, regulators of translation in eukaryotes from yeasts to humans
5. Antiviral actions of interferon, interferon-regulated cellular proteins and their surprisingly selective antiviral activities
6. Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2
7. The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis
8. Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase
9. Double-stranded RNA-activated protein kinase (PKR) fused to green fluorescent protein induces apoptosis of human embryonic kidney cells: Possible role in the fas signaling pathway
10. Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase
11. Tumor suppresser function of the interferon-induced double-stranded RNA-activated protein kinase
12. Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation
13. Localization of Epstein-Barr virus-encoded RNAs EBER-1 and EBER-2 in interphase and mitotic Burkitt lymphoma cells
14. Identification and requirement of three ribosome binding domains in dsRNA-dependent protein kinase (PKR)
15. Nuclear localization of the interferon-inducible protein kinase PKR in human cells and transfected mouse cells
16. Organization of the double-stranded RNA-activated protein kinase DAI and virus-associated VA RNAI in adenovirus-2-infected HeLa cells
17. Potential Alu function: Regulation of the activity of double-stranded RNA-activated kinase PKR
18. Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control
19. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
20. Nucleocytoplasmic transport: Signals, mechanisms and regulation
21. Identification of a signal for rapid export of proteins from the nucleus
22. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs
23. Nuclear export receptors: From importin to exportin
24. Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression
25. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1
26. Possible involvement of double-stranded RNA-activated protein kinase (PKR) in the cell death by influenza virus infection
27. DNA sequencing with chain-terminating inhibitors
28. Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase
29. Activation of the apoptotic fas antigen-encoding gene upon influenza virus infection involving spontaneously produced beta-interferon
30. Double-stranded RNA-activated protein kinase (PKR) is negatively regulated by 60S ribosomal subunit protein L18
31. Double-stranded RNA-independent dimerization of interferon-induced protein kinase PKR and inhibition of dimerization by the cellular P58(IPK) inhibitor
32. The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro