A new spontaneous mouse mutation in the Kcne1 gene

Mammalian Genome

Volumn 11, Issue 10, 2000, Pages 831-835

  Letts, V A ^a   Valenzuela, A ^a   Dunbar, C ^a   Zheng, Q Y ^a   Johnson, K R ^a   Frankel, W N ^a  

^a JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; NUCLEOTIDE;

AMINO ACID SUBSTITUTION; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATAXIA; CHROMOSOMAL LOCALIZATION; CHROMOSOME 16; CHROMOSOME 21; CONTROLLED STUDY; EXON; GENE MUTATION; INBRED STRAIN; LONG QT SYNDROME; MEDICAL GENETICS; MOUSE; MOUSE MUTANT; NONHUMAN; PHENOTYPE; SEQUENCE HOMOLOGY; SPONTANEOUS MUTATION; STOP CODON;

ANIMALIA; ATAXIA; RODENTIA;

EID: 0033808723     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003350010178     Document Type: Article

References (23)

1. K(v)LQT1 and 1sK (minK) proteins associate to form the I(Ks) cardiac potassium current
2. Chromosome 16 Committee Report
3. Adult KCNE1-knockout mice exhibit a mild cardiac cellular phenotype
4. Developmental changes in ionic channel activity in the embryonic murine heart
5. Deafness and imbalance associated with inactivation of the secretory Na-K-2Cl co-transporter
6. Mutation of the Na-K-Cl co-transporter gene Slc12A2 results in deafness in mice
7. Involvement of 1sK-associated potassium channel in heart rate control of repolarization in a murine engineered model of Jervell and Lange-Nielsen syndrome
8. Mutation of the gene for 1sK associated with both Jervell and Lange-Nielsen and Romano-Ward forms of Long-QT syndrome
9. Pathology of the ear in the cardioauditory syndrome of Jervell and Lange-Nielsen (recessive deafness with electrocardiographic abnormalities)
10. Congenital deaf-mutism, functional heart disease with prolongation of the QT interval, and sudden death
11. Intracisternal A-type particle elements as genetic markers: Detection by repeat element viral element amplified locus-PCR
12. Replacement by homologous recombination of the mink gene with lacZ reveals restriction of mink expression to the mouse cardiac conduction system
13. I(SK), a slowly activating voltage-sensitive potassium channel. Characterization of multiple cDNAs and gene organization in the mouse
14. A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome
15. Coassembly of K(v)LQT1 and mink (1sK) proteins to form cardiac I(Ks), potassium channel
16. KCNE1 mutations cause Jervell and Lange-Nielsen syndrome
17. Mutations in the hminK gene cause long QT syndrome and suppress I(Ks) function
18. Alteration of channel activities and gating by mutations of slow I(SK) potassium channel
19. The MEV mouse linkage testing stock: Mapping 30 novel proviral insertions and establishment of an improved stock
20. IsK and KvLQT1: Mutation in either of the two subunits of the slow component of the delayed rectifier potassium channel can cause Jervell and Lange-Nielsen syndrome
21. Inner ear defects induced by null mutation of the isk gene
22. Subunit composition of Mink potassium channels
23. Assessment of hearing in eighty inbred strains of mice by ABR threshold analyses