Monoselenolipoic acid may be an outstanding pharmaceutical antioxidant with direct thioredoxin-like activity

Medical Hypotheses

Volumn 55, Issue 3, 2000, Pages 185-186

  McCarty, M F ^a  

^a Pantox Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; MONOSELENOLIPOIC ACID; SELENIUM DERIVATIVE; THIOCTIC ACID; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; CEREBROVASCULAR DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETIC NEUROPATHY; ENZYME ACTIVITY; HUMAN; MULTICENTER STUDY; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SHORT SURVEY; STROKE;

EID: 0033805962     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1054/mehy.1999.1009     Document Type: Article

References (23)

1. Dihydrolipoic acid - A universal antioxidant both in the membrane and in the aqueous phase
2. Alpha-lipoic acid as a biological antioxidant
3. Neuroprotection by the metabolic antioxidant α-lipoic acid
4. α-Lipoic acid reduction by mammalian cells to the dithiol form, and release into the culture medium
5. Glutathione reductase and lipoamide dehydrogenase have opposite sterospecificities for α-lipoic acid enantiomers
6. Reduction of lipoic acid by lipoamide dehydrogenase
7. Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase
8. Thioredoxin fragment 31-36 is reduced by dihydrolipoamide and reduces oxidized protein
9. Thioredoxin catalyzes the reduction of insulin disulfides by dithiothreitol and dihydrolipoamide
10. α-Lipoic acid is a potent inhibitor of NF-κB activation in human T cells
11. Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1
12. Differential reactivity of the functional sulfhydryl groups of cysteine-32 and cysteine-35 present in the reduced form of thioredoxin from Escherichia coli
13. Selenocysteine
14. Mutants of Escherichia coli K-12 that are resistant to a selenium analog of lipoic acid identify unknown genes in lipoate metabolism
15. Thioctic acid protects against ischemia-reperfusion injury in the isolated perfused Langendorff heart
16. Cardiac recovery during post-ischemic reperfusion is improved by combination of vitamin E with dihydrolipoic acid
17. Effect of α-lipoic acid and dihydrolipoic acid on ischemia/reperfusion injury of the heart and heart mitochondria
18. The influence of vitamin E and dihydrolipoic acid on cardiac energy and glutathione status under hypoxia-reoxygenation
19. The free radical scavenger, alpha-lipoic acid, protects against cerbral ischemia-reperfusion injury in gerbils
20. Alpha-Lipoic acid protects against reperfusion following cerebral ischemia in rats
21. Efficacy of thioctic acid in the therapy of peripheral diabetic neuropathy
22. Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant α-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN study)
23. Effects of treatment with the antioxidant α-lipoic acid on cardiac autonomic neuropathy in NIDDM patients. A 4-month randomized controlled multicenter trial (DEKAN study)