The effect of FSH on male germ cell survival and differentiation in vitro is mimicked by pentoxifylline but not insulin

Molecular Human Reproduction

Volumn 6, Issue 10, 2000, Pages 877-881

  Tesarik, Jan ^a,b   Mendoza, Carmen ^b,c   Greco, Ermanno ^d  

^a LABORATOIRE D EYLAU   (France)

^b Molecular Assisted Reproduction and Genetics   (Spain)

^c UNIVERSITY OF GRANADA   (Spain)

^d EUROPEAN HOSPITAL   (Italy)

Author keywords

FSH; In vitro spermatogenesis; Insulin; Male germ cell; Pentoxifylline

Indexed keywords

CYCLIC AMP; DNA; FOLLITROPIN; INSULIN; PENTOXIFYLLINE; SOMATOMEDIN C RECEPTOR;

APOPTOSIS; ARTICLE; AZOOSPERMIA; CELL DIFFERENTIATION; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; GERM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MALE; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; SPERMATOGENESIS;

EID: 0033804511     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/6.10.877     Document Type: Article

References (39)

1. Evidence that secretion of immunoreactive inhibin by seminiferous tubules from the adult rat testis is regulated by specific germ cell types: Correlation between in vivo and in vitro studies
2. Severe impairment of spermatogenesis in mice lacking the CREM gene
3. Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men
4. The actions of insulin-like growth factors I and II on cultured Sertoli cells
5. Pituitary adenylate cyclase-activating polypeptide gene expression regulated by a testis-specific promoter in germ cells during spermatogenesis
6. The cytology of the testis
7. Induction of CREM activator proteins in spermatids: Down-stream targets and implications for haploid germ cell differentiation
8. Humanacrosome biogenesis: Immunodetection of proacrosin in primary spermatocytes and of its partitioning pattern during meiosis
9. CBP-independent activation of CREM and CREB by the LIM-only protein ACT
10. Pituitary hormone FSH directs the CREM functional switch during spermatogenesis
11. Insulin-like growth factor (IGF)-II binding to IGF-1 binding proteins and IGF receptors is modified by deletion of the N-terminal hexapeptide or substitution of arginine for glutamate-6 in IGF-II
12. In vitro, follicle-stimulating hormone prevents apoptosis and stimulates deoxyribonucleic acid synthesis in the rat seminiferous epithelium in a stage-specific fashion
13. Inhibin B: A likely candidate for the physiologically important form of inhibin in men
14. DNA damage in round spermatids of mice with a targeted disruption of the Pplcγ gene and in testicular biopsies of patients with non-obstructive azoospermia
15. The influence of insulin and insulin-like growth factor-I on hexose transport by Sertoli cells
16. Stage and cell-specific expression of the adenosine 3',5' monophosphate-diesterase genes in the rat seminierous epithelium
17. Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice
18. Developmental regulation of unique adenosine 3',5'-monophosphate-specific phosphodiesterase variants during rat spermatogenesis
19. Regulation of the seminiferous epithelium
20. Regulation of Sertoli cell inhibin production and of inhibin α-subunit mRNA levels by specific germ cell types
21. Insulin-like growth factors and their binding proteins
22. Round spermatids show normal testis-specific Hlt but reduced cAMP-responsive element modulator and transition protein I expression in men with round-spermatid maturation arrest
23. Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility
24. Differentiation of spermatogenic cells during in-vitro culture of testicular biopsy samples from patients with obstructive azoospermia: Effect of recombinant follicle stimulating hormone
25. Human spermatogenesis in vitro: Respective effects of follicle-stimulating hormone and testosterone on meiosis, spermiogenesis, and Sertoli cell apoptosis
26. Germ cell apoptosis in men with complete and incomplete spermiogenesis failure
27. Restoration of fertility by in-vitro spermatogenesis
28. In-vitro spermatogenesis
29. In vitro culture facilitates the selection of healthy spermatids for assisted reproduction
30. In-vitro spermatogenesis resumption in men with maturation arrest: Relationship with in-vivo blocking stage and serum FSH
31. Immunoreactive sites and accumulation of somatomedin-C in rat Sertoli-spermatogenic cell co-cultures
32. Insulin-like growth factor-I (IGF-I)and IGF-I receptor in human testis: An immunohistochemical study
33. Androgens promote oocyte insulin-like growth factor I expression and initiation of follicle development in the primate ovary
34. Role of transcription factors CREB and CREM in cAMP-regulated transcription during spermatogenesis
35. Testicular cAMP responsive element modulator (CREM) protein is expressed in round spermatids but is absent or reduced in men with round spermatid maturation arrest
36. Effects of follicle-stimulating hormone and serum substitution on the in-vitro growth of human ovarian follicles
37. Stage-specific regulation of stem cell factor gene expression in the rat seminiferous epithelium
38. Stem cell factor protects germ cells from apoptosis in vitro