Organic vanadium chelators potentiate vanadium-evoked glucose metabolism in vitro and in vivo: Establishing criteria for optimal chelators

Molecular Pharmacology

Volumn 58, Issue 4, 2000, Pages 738-746

  Goldwaser, Itzhak ^a   Qian, Sun ^a   Gershonov, Eytan ^a   Fridkin, Mati ^a   Shechter, Yoram ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 14; CATION; CHELATING AGENT; GLUCOSE; LIGAND; PIG INSULIN; VANADIUM DERIVATIVE;

ADIPOCYTE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL FREE SYSTEM; CONTROLLED STUDY; DIABETES MELLITUS; DRUG POTENTIATION; GLUCOSE METABOLISM; INSULIN TREATMENT; LIGAND BINDING; LIPOGENESIS; MALE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; SACCHAROMYCES CEREVISIAE;

EID: 0033802966     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.58.4.738     Document Type: Article

References (37)

1. The role of vanadium in the management of diabetes
2. The coordination and redox chemistry of vanadium in aqueous solution
3. Reaction chemistry of BMOV, bis(maltolato)oxovanadium (IV)- A potent insulin mimetic agent
4. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus
5. Enzyme interactions with labile oxovanadates and other polyoxometalates
6. Interaction of trace levels of vanadium (IV) and vanadium (V) in biological systems
7. Vanadate activates membranous nonreceptor protein tyrosine kinase in rat adipocytes
8. Vanadium activates or inhibits receptor and non-receptor protein tyrosine kinases in cell-free experiments, depending on its oxidation state. Possible role of endogenous vanadium in controlling cellular protein tyrosine kinase activity
9. Pervanadate [peroxide(s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase
10. In vivo and in vitro studies of vanadate in human and rodent diabetes mellitus
11. L-Glutamic acid γ-monohydroxamate. A potentiator of vanadium-evoked glucose metabolism in vitro and in vivo
12. The insulin-like effect of sodium vanadate on adipocyte glucose transport is mediated at a post-insulin-receptor level
13. Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects
14. Acid phosphatase
15. Evidence for the distinct vanadyl(+4)-dependent activating system for manifesting insulin-like effects
16. Vanadium-an element in search of a role
17. Bis(maltolato)oxovanadium(IV) is a potent insulin mimic
18. Oral administration of vanadate normalizes blood glucose levels in streptezotocin-treated rats. Characterization and mode of action
19. A simple free fat cell bioassay for insulin
20. The insulin-like effects of vanadate on lipolysis in rat adipocytes is not accompanied by an insulin-like effect on tyrosine phosphorylation
21. Vanadium compounds as insulin mimics
22. Komplexe XXXVII. Die EDTA-Komplexe des vanadiun (V)
23. Metabolism of isolated fat cells. I. Effect of hormones on glucose metabolism and lipolysis
24. Orally active and long-term acting insulin-mimetic vanadyl complex:bis(picolinato)oxovanadium (IV)
25. Kinetic analysis and comparison of uptake, distribution, and excretion of 48V-labeled compounds in rats
26. Insulin-mimetic effects of vanadate. Possible implications for future treatment of diabetes
27. Insulin-like stimulation of glucose oxidation in rat adipocytes by vanadyl (IV) ions
28. Insulin-like actions of vanadate are mediated in an insulin-receptor-independent manner via non-receptor protein tyrosine kinases and protein phosphotyrosine phosphatases
29. Hydrophobic carriers of vanadyl ions augment the insulinomimetic actions of vanadyl ions in rat adipocytes
30. A novel approach for evaluating tyrosine kinase activity based on the radioimmunological determination of phosphotyrosine
31. Quercetin selectively inhibits insulin receptor function in vitro and the bioresponses of insulin and insulinomimetic agents in rat adipocytes
32. Role of cytosolic tyrosine kinase in mediating insulin-like actions of vanadate in rat adipocytes
33. Vanadium and metabolic problems
34. The insulin-mimetic effect of vanadate is not correlated with insulin receptor tyrosine kinase activity, nor phosphorylation in mouse diaphragm in-vivo
35. Letter: Transition metal ion inhibition of enzyme-catalyzed phosphate ester displacement reactions
36. Antidiabetic action of vanadyl in rats independent of in vivo insulin-receptor kinase activity
37. Metabolism of added orthovanadate to vanadyl and high-molecular weight vanadates by Saccharomyces cerevisiae