Binding properties of a selective tritiated vasopressin V2 receptor antagonist, [3H]-SR 121463

Kidney International

Volumn 58, Issue 4, 2000, Pages 1613-1622

  Serradeil Le Gal, Claudine ^a,b   Raufaste, Danielle ^a,b   Double Cazanave, Eléonore ^a,b   Guillon, Gilles ^a,b   Garcia, Corinne ^a,b   Pascal, Marc ^a,b   Maffrand, Jean Pierre ^a,b  

^a SANOFI   (France)

^b CCIPE   (France)

Author keywords

Antidiuretic hormone; Arginine vasopressin; Homeostasis; Kidney; Ligand; Water regulation

Indexed keywords

1 [1 [4 (3 ACETAMIDOPROPOXY)BENZOYL] 4 PIPERIDYL] 1,2,3,4 TETRAHYDRO 2 QUINOLINONE; 1 [4 (N TERT BUTYLCARBAMOYL) 2 METHOXYBENZENE SULFONYL] 5 ETHOXY 3 SPIRO [4 (2 MORPHOLINOETHOXY)CYCLOHEXANE]INDOL 2 ONE; ARGIPRESSIN; COMPLEMENTARY DNA; CONIVAPTAN; MOZAVAPTAN; N TERT BUTYL 4 [5' ETHOXY 4 (2 MORPHOLINOETHOXY) 2' OXOSPIRO[CYCLOHEXANE 1,3' INDOLE] 1' SULFONYL] 3 METHOXYBENZAMIDE; RELCOVAPTAN; SYNTHETIC PEPTIDE; TRITIUM; UNCLASSIFIED DRUG; VASOPRESSIN; VASOPRESSIN RECEPTOR ANTAGONIST; VASOPRESSIN V2 RECEPTOR;

ANIMAL CELL; ANTIDIURESIS; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BINDING SITE; CHEMICAL STRUCTURE; CHO CELL; HUMAN; HUMAN CELL; KIDNEY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING;

EID: 0033802337     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2000.00322.x     Document Type: Article

References (56)

1. Receptors to vasopressin and other hormones in the mammalian kidney
2. Cloning and characterization of a vasopressin in V 2 receptor and possible link to nephrogenic diabetes insipidus
3. Molecular cloning of the receptor for human antidiuretic hormone
4. 2 [8-lysine] vasopressin and oxytocin receptors from a pig kidney cell line
5. An extracellular residue determines the agonist specificity of V 2 vasopressin receptors
6. Species heterogeneity and antidiuretic hormone antagonists: What are the predictors?
7. Evidence for the existence of vasopressin V 2 receptor mRNA in rat hippocampus
8. 2 receptor mRNA in rat brain
9. 2 receptor mRNA in human lung
10. Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide
11. Vasopressin receptor expression and mutation analysis in corticotropin-secreting tumors
12. Hemodynamic and coagulation responses to 1-desamino (8-D-arginine) vasopressin in patients with congenital nephrogenic diabetes insipidus
13. cAMP and extrarenal V 2 receptors in dogs
14. 2 receptor antagonism of DDAVP-induced release of hemostasis factors in conscious dogs
15. Hyponatremia pathophysiology, differential diagnosis and new aspects of treatment
16. 2-receptor antagonists: Panaceas for hyponatremia?
17. Design, synthesis and some uses of receptor-specific agonists and antogonists of vasopressin and oxytocin
18. Molecular neurobiology and pharmacology of the vasopressin/oxytocin receptor family
19. 1(a) receptors
20. 5Tyr(Me)VP in the rat brain, pituitary and kidney
21. 5, Sar']AVP: A selective radioligand for VI vasopressin receptors
22. Characterization of a novel linear radioiodinated vasopressin antagonist: An excellent radioligand for vasopressin V 1a receptors
23. Binding of [3H]-SR 49059, a potent nonpeptide vasopressin V(1a) antagonist, to rat and human liver membranes
24. 29]OVT: A selective OT receptor ligand
25. 1(a) receptors
26. Development and therapeutic indications of orallyactive non-peptide vasopressin receptor antagonists
27. 2 receptor antagonist
28. 1(a) receptors
29. 2 receptor antagonist
30. Potent aquaretic agent: A novel nonpeptide selective vasopressin 2 antagonist (OPC-31260) in men
31. Pharmacological profile of YM087, a novel potent nonpeptide vasopressin V1a and V2 receptor antagonist, in vitro and in vivo
32. 2 receptors
33. Isolation of Chinese hamster cell mutants deficient in dihydrofalate reductase activity
34. Rapid isolation of highly productive recombinant Chinese hamster ovary cell lines
35. Effect of a new, potent, non-peptide V1a vasopressin antagonist, SR 49059, on the binding and the mitogenic activity of vasopressin on Swiss 3T3 cells
36. Molecular mechanisms of novel antidiuretic antagonist: Analysis of the effects on vasopressin binding and adenylate cyclase activation in animal and human kidney
37. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding
38. Ligand: A versatile computerized approach for characterization of ligand-binding systems
39. 50) of an enzymatic reaction
40. 3H]-SR 49059
41. 2 vasopressin isoreceptors
42. 3H]-SKandF 101926
43. 2-receptors in rat kidney
44. I-Desamino-8-D-arginine vasopressin (DDAVP) as an agonist on V 1b vasopressin receptor
45. 2 receptor antagonist radioligand
46. Hepatic vasopressin receptors (VPRs) exhibit species heterogeneity-absence of VPRs in sheep liver
47. 3 pituitary vasopressin receptor: Ligand binding profile and density-dependent signaling pathways
48. Receptor-effector coupling by G proteins
49. 1 subtype receptor
50. Functional rescue of a mutant V2 vasopressin receptor by pre-treatment with a nonpeptidic antagonist
51. Autoradiographic localization of vasopressin and oxytocin binding sites in rat kidney
52. 2 receptor messenger ribounucleic acid in the liver and kidney of embryonic, developing and adult rats
53. The aquaporin family of water channels in kidney
54. Water channels in the kidney collecting duct
55. 2-induced vasodilatation in dogs
56. V2 receptor-mediated vasodilatation in healthy humans