Human DNA-demethylating activity: A glycosylase associated with RNA and PCNA

Journal of Cellular Biochemistry

Volumn 79, Issue 2, 2000, Pages 249-260

  Vairapandi, Mariappan ^a   Liebermann, Dan A ^a   Hoffman, Barbara ^a   Duker, Nahum J ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5 meC DNA glycosylase; Base excision repair; Demethylation; PCNA; RNA

Indexed keywords

5 METHYLCYTOSINE; CYCLINE; DNA; DNA GLYCOSYLTRANSFERASE; NUCLEAR FACTOR; NUCLEAR PROTEIN; PROTEIN; RNA;

ARTICLE; CPG ISLAND; DEMETHYLATION; DNA CLEAVAGE; DNA DETERMINATION; DNA METHYLATION; DNA REPLICATION; EXCISION REPAIR; HUMAN; HUMAN CELL; ION EXCHANGE; PRIORITY JOURNAL; PROTEIN PURIFICATION; RNA ANALYSIS; TRANSCRIPTION REGULATION;

BASE SEQUENCE; CPG ISLANDS; DNA METHYLATION; DNA, SINGLE-STRANDED; HELA CELLS; HUMAN; KINETICS; N-GLYCOSYL HYDROLASES; PROLIFERATING CELL NUCLEAR ANTIGEN; RNA; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T;

EID: 0033799985     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4644(20001101)79:2<249::AID-JCB80>3.0.CO;2-Z     Document Type: Article

References (56)

1. DNA methylation: The effect of minor bases on DNA-protein interactions
2. Cloning and sequencing of a cDNA encoding DNA methyl-transferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases
3. A mammalian protein with specific demethylase activity for mCpG DNA
4. Gene expression. The amazing demethylase
5. The photochemistry of 5-methylcytosine and 5-methyldeoxycytidine in aqueous solution
6. DNA demethylase is a processive enzyme
7. Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21(WAF1)
8. DNA containing a chemically reduced apurinic site is a high affinity ligand for the E. coli formamidopyrimidine-DNA glycosylase
9. Down-regulation of human DNA-(cytosine-5)-methyltransferase induces cell cycle regulators p16(ink4A) and p21(WAF/Cip1) by distinct mechanisms
10. Demethylation of DNA by purified chick embryo 5-methylcytosine-DNA glycosylase requires both protein and RNA
11. Mutagenic and epigenetic effects of DNA methylation
12. Methylation, mutation and cancer
13. Proliferating cell nuclear antigen: More than a clamp for DNA polymerases
14. Transient DNA methylation in differentiating mouse myoblasts correlates with higher activity of 5-methyldeoxycytidine excision repair
15. Mechanisms of DNA demethylation in chicken embryos. Purification and properties of a 5-methylcytosine-DNA glycosylase
16. The RNA moiety of chick embryo 5-methylcytosine-DNA glycosylase targets DNA demethylation
17. A re-investigation of the ribonuclease sensitivity of a DNA demethylation reaction in chicken embryo and G8 mouse myoblasts
18. A chicken embryo protein related to the mammalian DEAD box protein p68 is tightly associated with the highly purified protein-RNA complex of 5-methylcytosine-DNA glycosylase
19. Structural and functional similarities of prokaryotic and eukaryotic DNA polymerase sliding clamps
20. PCNA: Structure, functions and interactions
21. Protein-PCNA interactions: A DNA-scanning mechanism?
22. Transcriptional regulation of rat cyclin D1 gene by CpG methylation status in promoter region
23. Detection of 5-methylcytosine removal from DNA of friend erythroleukemia cells following exposure to several differentiating agents
24. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
25. Suppression of intestinal neoplasia by DNA hypomethylation
26. The role of DNA methylation in cancer genetic and epigenetics
27. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
28. Genome loosses all 5-methylcytosine in a life span. How is this connected with accumulations of mutations during aging?
29. Ultrasensitive stain for proteins in polyacrylamide gels shows regional variation in cerebrospinal fluid proteins
30. The purification of a mismatch specific Thymine specific DNA glycosylase from HeLa cells
31. Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase
32. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex
33. Gene silencing in mammalian cells by direct incorporation of electroporated 5-methyldeoxycytidine-5'-triphosphate
34. Inhibition of nucleotide excision repair by the cyclin-dependent kinase inhibitor p21
35. DNA methylation is a reversible biological signal
36. Replacement of 5-methylcytosine by cytosine: A possible mechanism for transient DNA demethylation during differentiation
37. DNA methylation and gene expression
38. 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes
39. Human Alu subfamilies and their methylation revealed by blot hybridization
40. Alu: Structure, origin, evolution, significance and function of one-tenth of human DNA
41. Involvement of DNA methylation in human carcinogenesis
42. Enzymic removal of 5-methylcytosine from poly (dG-5-methyl-dC) by HeLa cell nuclear extracts is not by a DNA glycosylase
43. Analysis of putative RNase sensitivity and protease insensitivity of demethylation activity in extracts from rat myoblasts
44. DNA methylation properties: Consequences for pharmacology
45. Formation of methylation patterns in the mammalian genome
46. Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis
47. Enzymic removal of 5-methylcytosine from DNA by a human DNA-glycosylase
48. Excision of ultraviolet induced photoproducts of 5-methylcytosine from DNA
49. Partial purification and characterization of human 5-methylcytosine DNA glycosylase
50. The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21(WAF1/CIP1)
51. 5-meC in genes with methylation dependent regulation
52. Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation
53. Cytosine methylation and the ecology of intragenomic parasites