Comparative bioavailability of two formulations containing atenolol and chlortalidone associated in a 4:1 fixed combination

Arzneimittel-Forschung/Drug Research

Volumn 50, Issue 9, 2000, Pages 802-808

  Marzo, A ^a   Ceppi Monti, N ^a   Dal Bo, L ^a   Mazzucchelli, P ^a   Crivelli, F ^a   Aleotti Tettamanti, R ^a   Ismaili, S ^a   Uhr, M R ^a   Ronchi, C ^a   Porziotta, E ^a  

^a IPAS   (United States)

Author keywords

Atenolol bioavailability, pharmaceutical combination; CAS 29122 68 7; CAS 77 36 1; Chlortalidone, bioavailability, pharmaceutical combination

Indexed keywords

ATENOLOL; CHLORTALIDONE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG MARKETING; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPERTENSION; MALE; PRACTICE GUIDELINE; STATISTICAL ANALYSIS; SYSTOLIC BLOOD PRESSURE;

EID: 0033799885     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300292     Document Type: Article

References (12)

1. Atenolol: A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disorders
2. Pharmacokinetic studies with chlortalidone (Hygroton®) in man
3. Pharmacokinetic analysis, bioavailability and operating guidelines
4. Bioequivalence: An updated reappraisal addressed to applications of interchangeable multi-source pharmaceutical products
5. A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability
6. An approach for widening the bioequivalence acceptance limits in the case of highly variable drugs
7. Sample size determination: Extended tables for the multiplicative model and bioequivalence ranges of 0.90 to 1.11 and 0.70 to 1.43
8. A comparison of the pharmacokinetics of atenolol, metoprolol, oxprenolol and propranolol in elderly hypertensive and young healthy subjects
9. Clinical pharmacological observations on atenolol, a beta-adrenoceptor blocker
10. Kinetics and absolute bioavailability of atenolol
11. Dose-dependent urinary excretion of chlortalidone