Amine group of guanine enhances the binding of norfloxacin antibiotics to DNA

European Journal of Biochemistry

Volumn 267, Issue 19, 2000, Pages 6018-6024

  Lee, Eun Jeong ^a   Yeo, Jeong Ah ^a   Cho, Chang Beom ^a   Lee, Gil Jun ^a   Han, Sung Wook ^b   Kim, Seog K ^a  

^a Yeungnam University   (South Korea)

^b Kyungwoon University   (South Korea)

Author keywords

DNA; Fluorescence spectroscopy; Norfloxacin; Polarized spectroscopy; Quinolone

Indexed keywords

AMINE; GUANINE; NORFLOXACIN; POLYNUCLEOTIDE;

ABSORPTION SPECTROSCOPY; ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; DIPOLE; DNA HELIX; DRUG DNA BINDING; FLUORESCENCE SPECTROSCOPY; INTERCALATION COMPLEX; LINEAR DICHROISM; MELTING POINT; PRIORITY JOURNAL;

ANIMALS; ANTI-INFECTIVE AGENTS; CALORIMETRY; CATTLE; CIRCULAR DICHROISM; DNA; GUANINE; NORFLOXACIN; SPECTROMETRY, FLUORESCENCE;

EID: 0033797983     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01677.x     Document Type: Article

References (23)

1. Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: The target of the drugs is DNA
2. Mechanism of inhibition of DNA gyrase by quinolone antibacterials: A cooperative drug-DNA binding model
3. Quinolone binding to DNA is mediated by magnesium ions
4. Binding mode of norfloxacin to calf thymus DNA
5. Interaction between norfloxacin and single stranded DNA
6. The orientation of norfloxacin bound to double-stranded DNA
7. Base specific complex formation of norfloxacin with DNA
8. Mechanism of quinolone inhibition of DNA gyrase
9. Mechanism of inhibition of DNA gyrase by quinolone antibacterials: Specificity and cooperativity of drug binding to DNA
10. A reply: 'Do quinolones bind to DNA?' - Yes
11. Do quinolones bind to DNA?
12. The CD of ligand-DNA systems. 1. Poly(dG-dC) B-DNA
13. The CD of ligand-DNA systems. 2. Poly(dA-dT) B-DNA
14. Critical aspects of measurement of circular and linear dichroism; a device for absolute calibration
15. Linear dichroism spectroscopy of nucleic-acids
16. Analyzing DNA complexes by circular and linear dichroism
17. Binding of ethidium bromide to a DNA triplex; evidence for intercalation
18. Intercalative interactions of ethidium dyes with triplex structures
19. Binding of 4',6-diamidino-2-phenylindole (Dapi) to at regions of DNA; evidence for an allosteric conformational change
20. 2] studied by CD, LD and normal absorption
21. DNA structural features responsible for sequence-dependent binding geometries of Hoechst-33258