A phase II pharmacodynamic study of pyrazoloacridine in patients with metastatic colorectal cancer

Cancer Chemotherapy and Pharmacology

Volumn 46, Issue 3, 2000, Pages 251-254

  Pelley, Robert ^a   Ganapathi, Ram ^a   Wood, Laura ^a   Rybicki, Lisa ^a   McLain, Denise ^a   Budd, G Thomas ^a,a   Peereboom, David ^a   Olencki, Thomas ^a   Bukowski, Ronald M ^a  

^a TAUSSIG CANCER INSTITUTE   (United States)

Author keywords

Colorectal cancer; Metastatic; Phase II trial; Pyrazoloacridine

Indexed keywords

2 (2 DIMETHYLAMINOETHYL) 9 METHOXY 5 NITROPYRAZOLO[3,4,5 KL]ACRIDINE;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CLINICAL ARTICLE; CLINICAL TRIAL; COLORECTAL CANCER; DOSE RESPONSE; DRUG BLOOD LEVEL; FEMALE; HUMAN; MALE; METASTASIS; NEUROLOGIC DISEASE; NEUTROPENIA; PHARMACODYNAMICS; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL;

ACRIDINES; ADULT; AGED; ANTINEOPLASTIC AGENTS; COLONIC NEOPLASMS; FEMALE; HUMANS; INTERCALATING AGENTS; MALE; MIDDLE AGED; NEOPLASM METASTASIS; NERVOUS SYSTEM DISEASES; NEUTROPENIA; PYRAZOLES; RECTAL NEOPLASMS;

EID: 0033797810     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800000139     Document Type: Article

References (23)

1. Current status of pyrazoloacridine as an anticancer agent
2. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate
3. Relation between two continuous variables
4. A phase II study of pyrazoloacridine in patients with advanced renal cell carcinoma
5. Phase I trial and pharmacokinetic study of pyrazoloacridine in children and young adults with refractory cancers
6. A phase II study of pyrazoloacridine in patients with advanced renal cell carcinoma
7. Cancer of the colon
8. A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal cancer
9. Pharmacokinetics of 9-methoxy-N,N-dimethyl-5-nitropyrazolo [3,4,5-k] acridine-2 (6H)-propanamine (PZA, PD 115394, NSC 366140) in mice: Guidelines for early clinical trials
10. Cytotoxicity and DNA damage associated with pyrazoloacridine in MCF-7 breast cancer cells
11. Biochemical and experimental chemotherapy studies of the pyrazoloacridines
12. The pyrazoloacridines: Approaches to the development of a carcinoma-selective cytotoxic agent
13. Nonparametric estimation from incomplete observations
14. Phase I clinical trial of pyrazoloacridine NSC 366140 (PD 115934)
15. Phase I and pharmacologic study of intermittent twice-daily oral therapy with capecitabine in patients with advanced and/or metastatic cancer
16. Reporting results of cancer treatment
17. Phase II trial of uracil and tegafur plus oral leucovorin: An effective oral regimen in the treatment of metastatic colorectal carcinoma
18. Phase I and pharmacologic studies of pyrazoloacridine, a novel DNA intercalating agent, on single-dosing and multiple-dosing schedules
19. Activity of the pyrazoloacridines against multidrug-resistant tumor cells
20. The final results of a large phase II study of the potent thymidylate synthase inhibitor Tomudex in advanced colorectal carcinoma
21. Phase II study of pyrazoloacridine in patients with advanced colorectal carcinoma
22. Evaluation of pyrazoloacridine in patients with advanced pancreatic carcinoma