Contribution of natural amino acid substitutions in SHV extended-spectrum β-lactamases to resistance against various β-lactams

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 10, 2000, Pages 2759-2763

  Randegger, C C ^a   Keller, A ^a   Irla, M ^a   Wada, A ^a   Hachler, H ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; AZTREONAM; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; CEFALOTIN; CEFEPIME; CEFOTAXIME; CEFOXITIN; CEFPODOXIME; CEFTAZIDIME; CEFTRIAXONE; ENZYME SHV 1; ENZYME SHV 8; PLASMID DNA; SIGNAL PEPTIDE; TETRACYCLINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; ESCHERICHIA COLI; EXPRESSION VECTOR; GENETIC RESISTANCE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STRAIN DIFFERENCE; STRUCTURAL GENE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; ANTIBIOTICS, LACTAM; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CLONING, MOLECULAR; DNA, BACTERIAL; ESCHERICHIA COLI; GENETIC VECTORS; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES; PHENOTYPE; PLASMIDS; PROTEIN SORTING SIGNALS; SUPPORT, NON-U.S. GOV'T;

EID: 0033797679     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.10.2759-2763.2000     Document Type: Article

References (37)

1. Substitution of alanine for aspartate at position 179 in the SHV-6 extended-spectrum β-lactamase
2. Role of the omega-loop in the activity, substrate specificity, and structure of class A β-lactamase
3. SHV-7, a novel cefotaxime-hydrolyzing β-lactamase, identified in Escherichia coli isolates from hospitalized nursing home patients
4. A functional classification scheme for β-lactamases and its correlation with molecular structure
5. Use of an isogenic Escherichia coli panel to design tests for discrimination of β-lactamase functional groups of Enterobacteriaceae
6. Extended-spectrum β-lactamases: A plague of plasmids
7. Tem1 β-lactamase structure solved by molecular replacement and refined structure of the S235A mutant
8. β-Lactamase gene promoters of 71 clinical strains of Klebsiella oxytoca
9. Bases of variation in resistance to β-lactams in Klebsiella oxytoca isolates hyperproducing K1 β-lactamase
10. Studies on transformation of Escherichia coli with plasmids
11. Role of Ser-238 and Lys-240 in the hydrolysis of 3rd-generation cephalosporins by SHV-type β-lactamases probed by site-directed mutagenesis and 3-dimensional modeling
12. New shuttle vectors for Escherichia coli and Bacillus subtilis. IV. The nucleotide sequence of pHY300PLK and some properties in relation to transformation
13. More extended-spectrum β-lactamases
14. Detection of Klebsiella pneumoniae and Escherichia coli strains producing extended-spectrum β-lactamases
15. Evolution of plasmid-coded resistance to broad-spectrum cephalosporins
16. Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens
17. Extended-spectrum and inhibitor-resistant TEM-type β-lactamases: Mutations, specificity, and three-dimensional structure
18. β-Lactamases in laboratory and clinical resistance
19. Extended spectrum β-lactamases
20. Molecular bases for interactions between β-lactam antibiotics and β-lactamases
21. Catalytic properties of class A β-lactamases: Efficiency and diversity
22. Structural basis of extended spectrum TEM β-lactamases: Crystallographic, kinetic, and mass spectrometric investigations of enzyme mutants
23. Molecular characterization of the gene encoding SHV-3 β-lactamase responsible for transferable cefotaxime resistance in clinical isolates of Klebsiella pneumoniae
24. New system based on site-directed mutagenesis for highly accurate comparison of resistance levels conferred by SHV β-lactamases
25. Structural features related to hydrolytic activity against ceftazidime of plasmid-mediated SHV-type CAZ-5 β-lactamase
26. Systematic mutagenesis of the active site omega loop of TEM-1 β-lactamase
27. Extended-spectrum β-lactamases
28. Different promoters of SHV-2 and SHV-2a β-lactamase lead to diverse levels of cefotaxime resistance in their bacterial producers
29. Evolution of extended-spectrum β-lactam resistance (SHV-8) in a strain of Escherichia coil during multiple episodes of bacteremia
30. DNA sequencing with chain-termination inhibitors
31. Extended-spectrum plasmid-mediated β-lactamases
32. A simple and reliable method to screen isolates of Escherichia coli and Klebsiella pneumoniae for the production of TEM- and SHV-derived extended-spectrum β-lactamases
33. Characterization of TEM-1 β-lactamase mutants from positions 238 to 241 with increased catalytic efficiency for ceftazidime
34. SHV-13, a novel extended-spectrum β-lactamase, in Klebsiella pneumoniae isolates from patients in an intensive care unit in Amsterdam