Pivagabine decreases stress-related hormone secretion in women with hypothalamic amenorrhea

Journal of Endocrinological Investigation

Volumn 23, Issue 8, 2000, Pages 526-532

  Genazzani, A D ^a   Stomati, M ^b   Bersi, C ^b   Luisi, S ^b   Fedalti, M ^c   Santuz, M ^c   Esposito, G ^d   Petraglia, F ^c   Genazzani, A R ^b  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c UNIVERSITY OF UDINE   (Italy)

^d Università Politecnica delle Marche ACRAF Gruppo Angelini   (Italy)

Author keywords

Hypothalamic amenorrhea; Hypothalamus pituitary adrenal axis; Pivagabine; Stress; Weight loss

Indexed keywords

CORTICOTROPIN; FOLLITROPIN; GROWTH HORMONE; HYDROCORTISONE; LUTEINIZING HORMONE; PIVAGABINE; PROLACTIN;

AMENORRHEA; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FEMALE; HORMONAL REGULATION; HORMONE BLOOD LEVEL; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; NEUROENDOCRINE SYSTEM; PULSATILE HORMONE RELEASE; RANDOMIZED CONTROLLED TRIAL; REGULATORY MECHANISM; STRESS; WEIGHT REDUCTION;

EID: 0033796657     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03343769     Document Type: Article

References (37)

1. Psychogenic or 'hypothalamic' amenorrhea
2. Neuroendocrine aberrations in women with functional hypothalamic amenorrhea
3. Spontaneous episodic release of adenohypophyseal hormones in hypothalamic amenorrhea
4. Hypothalamic amenorrhea: Neuroendocrine mechanisms/stress-induced anomalies
5. Menstrual cycles: Fatness as a determinant of minimum weight for height necessary for their maintenance or onset
6. Stress and the reproductive cycle
7. Naltrexone treatment restores menstrual cycles in patients with weight loss-related amenorrhea
8. Treatment with naltrexone in hypothalamic ovarian failure: Induction of ovulation and pregnancy
9. Acetyl-l-carnitine as possible drug in the treatment of hypothalamic amenorrhea
10. The role of endogenous opiates on LH secretion during the menstrual cycle
11. Impairment of opioid control of luteinizing hormone secretion in menstrual disorders
12. Opioid control of LH secretion in humans: Menstrual cycle, menopause and aging reduce effect of naloxone but not of morphine
13. GABAa receptors and anxiety
14. GABAergic and dopaminergic transmission in the rat cerebral cortex: Effect of stress, anxiolytic and anxiogenic drugs
15. Foot shock and anxiogenic beta-carbolines increase t-[35S]-butylbicyclophosphorotionate binding in the rat cerebral cortex, an effect opposite to anxiolytic and gamma-aminobutyric acid mimetics
16. In vitro and in vivo effects of the triazolobenzodiazepine alprazolam and hypothalamic-pituitary-adrenal function: Pharmacological and clinical implications
17. Chlordiazepoxide attenuates stress-induced accumulation of corticotropin-releasing factor mRNA in the paraventricular nucleus
18. Chlordiazepoxide attenuates stress-induced activation of neurons, corticotropin-releasing factor (CRF) gene transcription and CRF biosynthesis in the paraventricular nucleus (PVN)
19. Properties of two derivatives of gamma-aminobutyric acid (GABA) capable of abolishing Cardiazol- and bicuculline-induced convulsions in the rat
20. Pivagabine: A novel psychoactive drug
21. Antagonism by pivagabine of stress-induced changes in GABA a receptor function and corticotropin-releasing factor concentrations in rat brain
22. Long-term GnRH agonist administration revealed a GnRH independent mechanism stimulating FSH discharge in humans
23. Evaluation of methods for detection of pulsatile hormone secretion: Sensitivity vs. specificity
24. Detection and characterization of peaks and estimation of instantaneous secretory rate for episodic pulsatile hormone secretion
25. Regulation of reproductive hormone secretion in primates by short-term changes in nutrition
26. Effects of pivagabine on psychophysical performance and behavioural response in experimental models of stress
27. Role of pivagabine in the treatment of climateric syndrome
28. Modulatory role of estrogens and progestins on growth hormone episodic release in women with hypothalamic amenorrhea
29. Hypothalamic amenorrhea: Evidence of a central derangement of hypothalamic-pituitary-adrenal cortex axis activity
30. Corticotropin releasing factor and amphetamine exaggerate partial agonist properties of benzodiazepine antagonist Ro 15-1788 in the conflict test
31. Brain benzodiazepine receptor control of stress hormones
32. Acute effects of alprazolam and adinazolam on the concentrations of corticotropin-releasing factor in the rat brain
33. Corticotropin-releasing hormone inhibition of growth hormone-releasing hormone-induced growth hormone release in man
34. Neurosteroids: Biosynthesis and function
35. Stress-induced elevation of γ-aminobutyric acid type A receptor-active steroids in the rat brain
36. Stressful life events and affective disorders inhibit pulsatile LH secretion in hypothalamic amenorrhea