Cytotoxicity and probable mechanism of action of sulphimidazole

Journal of Antimicrobial Chemotherapy

Volumn 46, Issue 4, 2000, Pages 541-550

  Castelli, Mario ^a   Malagoli, Monica ^a   Lupo, Lucia ^a   Roffia, Sergio ^b   Paolucci, Francesco ^b   Cermelli, Claudio ^a   Zanca, Andrea ^c   Baggio, Giosuè ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c CARLO POMA HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROIMIDAZOLE; FUNCTIONAL GROUP; METRONIDAZOLE; NIMORAZOLE; NITROIMIDAZOLE; ORNIDAZOLE; RADICAL; SECNIDAZOLE; SULFADIAZINE; SULFAMETHOXAZOLE; SULFANILAMIDE; SULFONAMIDE; SULPHIMIDAZOLE; TINIDAZOLE; TRIMETHOPRIM; UNCLASSIFIED DRUG;

AEROBIC BACTERIUM; ANAEROBIC BACTERIUM; ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; CELL LYSATE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENTIATION; DRUG STRUCTURE; HYPOTHESIS; IN VITRO STUDY; MICROBIOLOGY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PROTEIN CONTENT; STRUCTURE ACTIVITY RELATION; VERO CELL;

EID: 0033793591     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/46.4.541     Document Type: Article

References (31)

1. Synthesis and biological properties of 1-methyl-2-((4-aminophenyl)-sulfonyl-)amino-5-nitro-imidazole
2. In vitro activity of sulphimidazole alone and in association with trimethoprim against enteric pathogens
3. In vitro activity of trimethoprim in association with sulfimidazole against aerobic gram-negative and gram-positive microorganisms and Clostridia
4. Inhibitory effects of prostaglandin A2 on c-myc expression and cell cycle progression in human leukaemia cell line HL-60
5. A quantitative and qualitative analysis of proteins found in vespid venoms
6. Antibiotic sensitivity testing. Report of an international collaborative study
7. In-vitro studies of two 5-nitroimidazole derivatives
8. Electron transfer rate constants for redox systems Fe(III)/Fe(II) complexes with 2,2'-bipyridine and/or cyanide ion as measured by the galvanostatic double pulse method
9. Electrochemical monitoring of valence bond isomers interconversion in bipyridyl-C61 anions
10. Stripping voltammetry
11. Electrochemical Methods
12. A very simple solid electrode with periodical renewal of the diffusion layer
13. Steady state voltammetry
14. Nanosecond time resolved cyclic voltammetry. Direct observation of electro-generated intermediates with bimolecular diffusion controlled decay using scan rates in the megavolt per second range
15. Thymidine content in commercially prepared media
16. Nitroimidazole drugs-action and resistance mechanisms. I. Mechanisms of action
17. Drug therapy: Metronidazole
18. Chemotherapeutically active nitro compounds. 4. 5-Nitroimidazoles
19. Nitroimidazoles with antibacterial activity against Neisseria gonorrhoeae
20. Nitroimidazoles: In vitro activity and efficacy in anaerobic infections
21. Effetto del trimethoprim sull'attivita antibatterica degli acidi nalidixico e oxolinico
22. Trimethoprim enhances the antibacterial activity of nalidixic and oxolinic acids and delays the emergence of resistance
23. Oxolinic acid-trimethoprim combination: Effects on DNA synthesis and on viability of Escherichia coli
24. Interaction of nitroimidazole drugs with DNA in vitro: Structure-activity relationships
25. Structure-cytotoxicity relationships of nitroimidazoles in an in-vitro system
26. Electrochemical characteristics of nitro-heterocyclic compounds of biological interest. IV. Lifetime of the metronidazole radical anion
27. Rapid mixing studies on the time-scheme of radiation damage in cells
28. Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine
29. Antibacterial activity and electron affinity of nitro-heterocyclic compounds
30. The activity of nitro-compounds against Bacteroides fragilis is related to their electron affinity
31. Effect of hyperthermia on differential cytotoxicity of a hypoxic cell radiosensitizer, Ro-07-0582, on mammalian cells in vitro