ortho-Toluidine

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans

Volumn 77, Issue , 2000, Pages 267-322

[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLANILINE; TOBACCO SMOKE; TOLUIDINE DERIVATIVE;

AIR; ANALYTIC METHOD; CANCER RESEARCH; CARCINOGENICITY; CHEMICAL INDUSTRY; CHEMICAL STRUCTURE; CONFERENCE PAPER; ENVIRONMENTAL EXPOSURE; EXPERIMENTAL ANIMAL; FOOD; GENOTOXICITY; HUMAN; NONHUMAN; OCCUPATIONAL EXPOSURE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; SOIL; TOXICOKINETICS; WATER CONTAMINATION;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; CRICETINAE; DISEASE MODELS, ANIMAL; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; INDICATORS AND REAGENTS; MALE; MAXIMUM ALLOWABLE CONCENTRATION; MICE; NEOPLASMS; RATS; TOLUIDINES;

EID: 0033792556     PISSN: 02509555     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (217)

1. Tests for gene mutational activity in the L5178Y/TK assay system
2. Induction of various genetic effects in the yeast Saccharomyces cerevisiae strain D7
3. Progress in mutation research, evaluation of short-term tests for carcinogens
4. Indirect methods of assessing the effects of tobacco use in occupational studies
5. Study of 42 coded compounds with the Salmonella/mammalian microsome assay
6. Tests with the Salmonella plate-incorporation assay
7. Variations on the standard protocol design of the hepatocyte DNA repair assay
8. Assays for unscheduled DNA synthesis in HeLa S3 cells
9. Tests with the Syrian hamster embryo cell transformation assay
10. Genotoxicity studies with the unstable Zeste-White (UZ) system of Drosophila melanogaster: Results with ten carcinogenic compounds
11. Further studies with the somatic White-Ivory system of Drosophila melanogaster: Genotoxicity testing of ten carcinogens
12. Genotoxic evaluation of ten carcinogens in the Drosophila melanogaster wing spot test
13. Biomonitoring of aromatic amines. II: Hemoglobin binding of some monocyclic aromatic amines
14. Measurement of DNA single-strand breaks by alkaline elution in rat hepatocytes
15. Hepatic macromolecular binding and tissue distribution of ortho- and para-toluidine in rats
16. Mutagenic activity of 42 coded compounds in the Salmonella/microsome assay with preincubation
17. The induction of mitotic gene conversion in the yeast Saccharomyces cerevisiae strain JDI
18. A biological monitoring method for o-toluidine and aniline in urine using high performance liquid chromatography with electrochemical detection
19. Hemoglobin adducts of aromatic amines: Associations with smoking status and type of tobacco
20. Assays in Aspergillus nidulans for the induction of forward-mutation in haploid strain 35 and for mitotic nondisjunction, haploidization and crossing-over in diploid strain PI
21. Evaluation of the yeast DEL assay with 10 compounds selected by the International Program on Chemical Safety for the evaluation of short-term tests for carcinogens
22. Evaluation of damage to DNA after in vivo exposure to different classes of chemicals
23. Metabolism of ortho-, meta-, and para-toluidine in the adult male rat
24. ortho-Toluidine blood protein adducts: HPLC analysis with fluorescence detection after a single dose in the adult male rat
25. Drug-induced methaemoglobinaemia. Treatment issues
26. Urinary bladder amino-tumours. Possible role of occupational exposure to o-toluidine and o-aminoazotoluene
27. Tests for mutagenic activity using mutation assays at two loci in the human lymphoblast cell lines TK6 and AHH-1
28. Zoro test
29. Tests for chromosome aberrations and aneuploidy in the Chinese hamster fibroblast cell line CH1-L
30. The genetic toxicology of ortho-toluidine
31. Cell transformation test with baby hamster kidney cells
32. Cytostatic drug activity in plasma, a bioassay for detecting mutagenicity of directly and indirectly acting chemicals, an evaluation of 20 chemicals
33. Binding characteristics of ortho-toluidine to rat hemoglobin and albumin
34. L-Arabinose resistance test with Salmonella typhimurium as a primary tool for carcinogen screening
35. Alkaline sucrose sedimentation, sister-chromatid exchange and micronucleus assays in CHO cells
36. Identification and quantitative determination of aniline and toluidines in human urine
37. Organic constituents of mutagenic secondary effluents from wastewater treatment plants
38. Tests with the Chinese hamster V79 inhibition of metabolic cooperation assay
39. Method 1625
40. High production volume (HPV) chemicals list
41. Mutascreen®, an automated bacterial mutagenicity assay
42. Health implications of nitrate and nitrite in drinking water: An update on methemoglobinemia occurrence and reproductive and developmental toxicity
43. Petite mutagenesis in Saccharomyces cerevisiae strain D5
44. Use of newt larvae for in vivo genotoxicity testing of water: Results on 19 compounds evaluated by the micronucleus test
45. Mutagenicity of benzidine and related compounds employed in the detection of hemoglobin
46. Tests for mutagenic activity at the HGPRT locus in Chinese hamster V79 cells in culture
47. Testing of known carcinogens and noncarcinogens in the Syrian hamster embyro (SHE) micronucleus test in vitro; correlations with in vivo micronucleus formation and cell transformation
48. The Drosophila reversion assay using the unstable zeste-white somatic eye color system
49. Tests for the induction of mutations to ouabain or 6-thioguanine resistance in mouse lymphoma L5178Y cells
50. Testing of some azo dyes and their reduction products for mutagenicity using Salmonella typhimurium TAI538
51. Mutagenic activity of 42 coded compounds in the 'Microtiter' fluctuation test
52. Assays to measure the induction of unscheduled DNA synthesis in cultured hepatocytes
53. Effect of toluidines on drug metabolizing enzymes in rat liver, kidney and lung
54. Splenic fibrosis and sarcomas in F344 rats fed diets containing aniline hydrochloride, p-chloroaniline, azobenzene, o-toluidine hydrochloride, 4,4'-sulfonyldianiline, or D and C Red No. 9
55. A differential killing test using an improved repair-deficient strain of Escherichia coli
56. Tests for the induction of chromosomal aberrations and sister chromatid exchanges in cultured Chinese hamster ovary (CHO) cells
57. Mutagenic studies of ortho-toluidine and its potential metabolites
58. Tests for mutagenic activity in growing cells of the yeast Saccharomyces cerevisiae strain XV185-14C
59. Assays for enhanced DNA viral transformation of primary Syrian hamster embryo (SHE) cells
60. Comparative carcinogenicity of o-toluidine hydrochloride and o-nitrosotoluene in F-344 rats
61. Bioassay for carcinogenicity of 3,2'-dimethyl-4-nitrosobiphenyl, o-nitrosotoluene, nitrosobenzene and the corresponding amines in Syrian golden hamsters
62. Significance of DNA and protein adducts
63. Fluctuation test with S9 and hepatocyte activation
64. IARC monographs on the evaluation of carcinogenic risks to humans
65. IARC monographs on the evaluation of carcinogenic risks to humans
66. IARC monographs on the evaluation of carcinogenic risks to humans
67. IARC monographs on the evaluation of carcinogenic risks to humans
68. IARC monographs on the evaluation of carcinogenic risks to humans
69. IARC monographs on the evaluation of of carcinogenic risks to humans
70. Mutagen testing of a series of paired compounds with the Ames Salmonella testing system
71. Tests for genetic activity in the yeast Saccharomyces cerevisiae: Study of forward and reverse mutation, mitotic recombination and illegitimate mating induction
72. The in vitro chromosomal aberration test using Chinese hamster lung (CHL) fibroblast cells in culture
73. Genetic activity of 42 coded compounds in the mitotic gene conversion assay using Saccharomyces cerevisiae strain D4
74. The DNA-damaging activity in 42 coded compounds in the rec-assay
75. Effect of lithocholic acid on the mutagenicity of some substituted aromatic amines
76. Assessing the predictiveness of the Syrian hamster embryo cell transformation assay for determining the rodent carcinogenic potential of single ring aromatic/nitroaromatic amine compounds
77. Problems of industrial hygiene and health status of workers engaged in the production of o-toluidine
78. Maternal hematologic disorders
79. Assays for the induction of gene mutations at the thymidine kinase locus and the hypoxanthine guanine phosphoribosyltransferase locus in L5178Y mouse lymphoma cells in culture
80. Comparison of 7 azo dyes and their azo reduction products in the rat and hamster hepatocyte primary culture/DNA-repair assays
81. Estimation of N-hydroxy-o-toluidine, a urinary metabolite of o-toluidine and o-nitrosotoluene, by high performance liquid chromatography with electrochemical detection
82. Assays for the induction of mutations to 6-thioguanine resistance in Chinese hamster V79 cells in culture
83. Assays for the induction of mutations to ouabain resistance in V79 Chinese hamster cells in culture with cell- or microsome-mediated metabolic activation
84. Induction of DNA single-strand breaks in CHO cells in culture
85. Tests for the induction of sister chromatid exchanges in Chinese hamster ovary (CHO) cells in culture
86. Assays for the induction of morphological transformation in C3H/10T 1/2 cells in culture with and without S9-mediated metabolic activation
87. The induction of gene mutations in the mouse lymphoma L5178Y/TK(+/-) assay and the Chinese hamster V79/HGPRT assay
88. Determination of polar organic solutes in oil-shale retort wastes
89. Induction of xenobiotic biotransformation by the insecticide chlordimeform, a metabolite 4-chloro-o-toluidine and a structurally related chemical o-toluidine
90. Mutation tests with Salmonella using 8-azaguanine resistance as the genetic marker
91. Chlorocarbons, -hydrocarbons (toluenes)
92. Induction of sister-chromatid exchanges by direct and indirect mutagens in human lymphocytes, co-cultured with intact rat liver cells. Effect of enzyme induction and preservation of the liver cells by freezing in liquid nitrogen
93. Assays for forward mutation in Schizosaccharomyces pombe strain PI
94. Salmonella/Microsome tests on 42 coded chemicals
95. The DNA repair inhibitors hydroxyurea and cytosine arabinoside enhance the sensitivity of the alkaline single-cell gel electrophoresis ('comet') assay in metabolically-competent MCL-5 cells
96. Mutation tests on Salmonella typhimurium by the preincubation method
97. Assays for morphological transformation and mutation to ouabain resistance of Balb/c-3T3 cells in culture
98. Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals
99. Assays of three carcinogen/non-carcinogen chemical pairs for in vivo induction of chromosome aberrations, sister chromatid exchanges and micronuclei
100. Tests for genetic activity in the yeast Saccharomyces cerevisiae using strains D7-144, XV185-14C and RM52
101. Mutagenic activity of 42 encoded compounds in the haploid yeast reversion assay, strain XV185-14C
102. Carcinogenesis by chemicals: An overview - G.H.A. Clowes Memorial Lecture
103. Assays for the induction of gene mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells in culture
104. Demonstration of mutagenicity of aniline and o-toluidine by norharman
105. Differences in effects of norharman with various classes of chemical mutagens and amounts of S-9
106. Mutagenic activity of 42 coded compounds in the Salmonella/microsome assay
107. SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: Examination with 151 chemicals
108. Tests for chromosome aberrations and sister-chromatid exchanges in Chinese hamster ovary (CHO) cells in culture
109. Chemically-induced sister-chromatid exchange in vivo in bone marrow of Chinese hamsters. An evaluation of 24 compounds
110. Tests with the C3H/10T 1/2 clone 8 morphological transformation bioassay
111. Primary and secondary amines in the human environment
112. Tests for the induction of sister-chromatid exchanges in human peripheral lymphocytes in culture
113. Tests for the induction of forward mutation at the thymidine kinase locus of L5178Y mouse lymphoma cells in culture
114. Occupational safety and health standards
115. A mortality survey of men engaged in the manufacture of organic dyes
116. Tests for the induction of chromosomal aberrations in Chinese hamster ovary (CHO) cells in culture
117. Induction of mitotic aneuploidy in the yeast strain D6 by 42 coded compounds
118. Tests for effects on mitosis and the mitotic spindle in Chinese hamster primary liver cells (CH1-L) in culture
119. The detection of mitotic gene conversion, point mutation and mitotic segregation using the yeast Saccharomyces cerevisiae strain D7
120. The induction of mitotic aneuploidy, point mutation and mitotic crossing-over in the yeast Saccharomyces cerevisiae strains D61-M and D6
121. Evaluation of the sister chromatid exchange method in mammalian cells as a screening system for carcinogens
122. Mortality among rubber chemical manufacturing workers
123. 4) cells
124. Tests for the induction of DNA-repair synthesis in primary cultures of adult rat hepatocytes
125. Mutation tests with Salmonella using the plate-incorporation assay
126. Mutagenic activity of 42 coded compounds in the Salmonella/microsome assay
127. Biomonitoring of urinary aromatic amines and arylamine, hemoglobin adducts in exposed workers and nonexposed control persons
128. Evaluation of the mutagenicity and DNA-modifying activity of carcinogens and noncarcinogens in microbial systems
129. DNA polymerase deficient assay
130. Mutagenicity of carcinogens and noncarcinogens in the Salmonella/microsome test
131. The carcinogenic effect of aromatic amines: An epidemiological study on the role of o-toluidine and 4,4'-methylene bis(2-methylaniline) in inducing bladder cancer in man
132. Identification of toxic impurities in commercial diphenylamine
133. Mutagenic activity of 41 compounds in the in vivo micronucleus assay
134. Tests with the Syrian hamster embryo (SHE) cell transformation assay
135. Assays for inhibition of metabolic cooperation between mammalian cells in culture
136. Reevaluating the carcinogenicity of ortho-toluidine: A new conclusion and its implications
137. Progress in mutation research, evaluation of short-term tests for carcinogens
138. Use of repair-deficient strains of yeast to assay the activity of 40 coded compounds
139. Induction of mitotic gene conversion by 41 coded compounds using the yeast culture JD1
140. Subacute toxicity of several ring-substituted dialkylanilines in the rat
141. In vitro mutagenicity assays of chemical carcinogens and related compounds with Salmonella typhimurium
142. Mutagenic activity of 42 coded compounds using 8-azaguanine resistance as a genetic marker in Salmonella typhimurium
143. 14C]toluidine in the F344 rat
144. Mortality study of workers employed at a plant manufacturing chemicals for the robber industry: 1955-86
145. A further cohort study of workers employed at a factory manufacturing chemicals for the rubber industry, with special reference to the chemicals 2-mercaptobenzothiazole (MBT), aniline, phenyl-beta-naphthylamine and o-toluidine
146. Carcinomas of the urinary bladder in a 4-chloro-o-toluidine cohort
147. GC/MS analysis of biologically important aromatic amines. Application to human dosimetry
148. Organic contaminants in groundwater near an underground coal gasification site in northeastern Wyoming
149. Activity of 42 coded compounds in the BHK-21 cell transformation test
150. + ATPase loci in two different mouse lymphoma cell lines in culture
151. Metabolic aspects of the comutagenic action of norharman
152. Assay for the carcinogenicity of chemical agents using enhancement of anchorage-independent survival of retrovirus-infected Fischer rat embryo cells
153. Mutagenicity of extracts of urine from rats treated with aromatic amines
154. Biological monitoring for occupational exposures to o-toluidine and aniline
155. Mutagenic activity of 42 coded compounds in the lambda induction assay
156. The induction of bacterial mutation and hepatocyte unscheduled DNA synthesis by monosubstituted anilines
157. Metabolism, mutagenicity and carcinogenicity of aromatic amines
158. Do induced sperm-head abnormalities in mice specifically identify mammalian mutagens rather than carcinogens?
159. Evaluation of some chemicals by the sperm morphology assay
160. Activity of coded compounds in the micronucleus test
161. Activity of 42 coded compounds in a differential killing test using Escherichia coli strains WP2, WP67 (uvrA polA), and CM871 (uvrA lexA recA)
162. Assays for inhibition of metabolic cooperation by a microassay method
163. The in vitro micronucleus test on isolated human lymphocytes
164. New volatile constituents of black tea aroma
165. The Drosophila somatic recombination and mutation assay (SRM) using the white-coral somatic eye color system
166. Bladder cancer in workers exposed to aniline
167. Excess number of bladder cancers in workers exposed to ortho-toluidine and aniline
168. A re-examination of the cause of excess bladder cancers in chemical plant workers
169. Monitoring of aromatic amine exposure in workers at a chemical plant with a known bladder cancer excess
170. Toxicity of and biological monitoring for 1,3-diamino-2,4,6-trinitrobenzene and other nitro-amino derivatives of benzene and chlorobenzene
171. Testing of twenty-one environmental aromatic amines or derivatives for long-term toxicity or carcinogenicity
172. The test for sister-chromatid exchanges in Chinese hamster V79 cells in culture
173. Tests with the rat hepatocyte primary culture/DNA-repair test
174. Water-soluble components of four fuel oils: Chemical characterization and effects on growth micro algae
175. Somatic mutation and recombination test in wings of Drosophila melanogaster
176. Assays for the induction of mutations to 6-thioguanine and ouabain resistance in Chinese hamster ovary (CHO) cells in culture
177. Assays for the induction of cell transformation in Chinese hamster ovary (CHO) cells and in Syrian hamster embryo (SHE) cells
178. Tests with a preincubation modification of the Salmonella/microsome assay
179. Induction of mitotic gene conversion in strain D7 of Saccharomyces cerevisiae by 42 coded chemicals
180. Tests for the induction of mitotic aneuploidy in the yeast Saccharomyces cerevisiae strain D61.M