Does full-term pregnancy at a young age protect women against breast cancer through hcg?

Obstetrics and Gynecology

Volumn 96, Issue 5, 2000, Pages 783-786

  Rao, Ch V ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; LUTEINIZING HORMONE;

ADOLESCENT PREGNANCY; ANTINEOPLASTIC ACTIVITY; BREAST CANCER; CANCER INCIDENCE; CANCER PREVENTION; CANCER RISK; CANCER TISSUE; HUMAN; HUMAN CELL; HUMAN TISSUE; MENOPAUSE; OVARIECTOMY; PRIORITY JOURNAL; PROGNOSIS; REVIEW;

BREAST NEOPLASMS; CHORIONIC GONADOTROPIN; FEMALE; HUMANS; LUTEINIZING HORMONE; MATERNAL AGE; PREGNANCY; RECEPTORS, ESTROGEN; RECEPTORS, GONADOTROPIN; RECEPTORS, LH;

EID: 0033791681     PISSN: 00297844     EISSN: 1873233X     Source Type: Journal    
DOI: 10.1016/s0029-7844(00)00983-2     Document Type: Editorial

References (13)

1. MacMahon B, Cole P, Liu M, Lowe CR, Mirra AP, Ravinhar H, et al. Age at birth and breast cancer risk. Bull World Health Org 1970;34:209-21.
2. Sinha DK, Pazik JE, Dao TL. Prevention of mammary carcinogenesis in rats by pregnancy: Effect of full-term and interrupted pregnancy. Br J Cancer 1988;57:390-4.
3. Russo IH, Russo J. Chorionic gonadotropin; a tumoristatic and preventive agent in breast cancer. In: Teicher BA, ed. Drug resistance in oncology. New York: Marcel Dekker 1993:537-60.
4. Guzman RC, Yang J, Rajkumar L, Thordarson G, Chen X, Nandi S. Hormonal prevention of breast cancer: Mimicking the protective effect of pregnancy. Proc Natl Acad Sci U S A 1999;96:2520-5.
5. Lojun S, Bao S, Lei ZM, Rao CV. The presence of functional luteinizing hormone-chorionic gonadotropin receptors in human breast cell lines: Implications supporting the premise that hCG protects women against breast cancer. Biol Reprod 1997;57:1202-10.
6. Tao YX, Lei ZM, Rao CV. Luteinizing hormone/human chorionic gonadotropin receptors in lactating rat mammary glands. Life Sci 1997;60:1297-303.
7. Meduri G, Charnaux N, Loosfelt H, Jolivet A, Spyratos F, Brailly S, et al. Luteinizing hormone-human chorionic gonadotropin receptors in breast cancer. Cancer Res 1997;57:857-64.
8. Hu YL, Lei ZM, Rao CV. Cis-acting elements and trans-acting proteins in the transcription of luteinizing hormone/human chorionic gonadotropin receptors gene in human breast cells. Breast J 1999;5:186-93.
9. Bernstein L, Hanisch R, Sullivan-Halley J, Ross RK. Treatment with human chorionic gonadotropin and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 1995;4:437-40.
10. Alvarado MV, Alvarado NE, Russo J, Russo IH. Human chorionic gonadotropin inhibits proliferation and induces expression of inhibin in human breast epithelial cells in vitro. in Vitro Cell Dev Biol 1994;30A:4-8.
11. Srivastava P, Russo J, Russo IH. Chorionic gonadotropin inhibits rat mammary carcinogenesis through activation of programmed cell death. Carcinogenesis 1997;18:1799-808.
12. Huynh H. in vivo regulation of the insulin-like growth factor system of mitogens by human chorionic gonadotropin. Int J Oncol 1998;13:571-5.
13. Huang Y, Bove B, Wu Y, Russo IH, Yang X, Russo J. Microsatellite instability during the immortalization and transformation of human breast epithelial cells in vitro. Mol Carcinogenesis 1999;24:118-27.