Coumarin

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans

Volumn 77, Issue , 2000, Pages 193-225

[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

COUMARIN; FRAGRANCE;

ANALYTIC METHOD; CANCER RESEARCH; CARCINOGENICITY; CHEMICAL INDUSTRY; CHEMICAL STRUCTURE; CONFERENCE PAPER; DRUG INDUSTRY; ENVIRONMENTAL EXPOSURE; EXPERIMENTAL ANIMAL; FOOD AND DRUG ADMINISTRATION; FOOD CONTAMINATION; GENOTOXICITY; HUMAN; NONHUMAN; OCCUPATIONAL EXPOSURE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; TOXICOKINETICS;

ANIMALS; ANTICOAGULANTS; ANTINEOPLASTIC AGENTS; CARCINOGENICITY TESTS; COUMARINS; CRICETINAE; DISEASE MODELS, ANIMAL; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; MALE; MICE; NEOPLASMS, EXPERIMENTAL; RATS; REPRODUCTION;

EID: 0033791240     PISSN: 02509555     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (134)

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5. Possible coumarin hepatotoxicity (Letter to the Editor)
6. Coumarin
7. Synthesis and reactivity of coumarin 3,4-epoxide
8. Selective Clara cell injury in mouse lung following acute administration of coumarin
9. Development of tolerance to Clara cell necrosis with repeat administration of coumarin
10. o-Hydroxyphenylacetaldehyde is a hepatotoxic metabolite of coumarin
11. Effects of coumarin following perinatal and chronic exposure in Sprague-Dawley rats and CD-1 mice
12. Frequency of coumarin hepatotoxicity
13. Treatment of lymphedema of the arms and legs with 5,6-benzo-[α]pyrone
14. Comparison of a novel thin-layer chromatographic-fluorescence detection method with a spectrofluorimetric method for the determination of 7-hydroxycoumarin in human urine
15. Critical review of the toxicology of coumarin with special reference to interspecies differences in metabolism and hepatotoxic response and their significance to man
16. Strain-specific enhancement or inhibition of coumarin hepatotoxicity in mice following pretreatment with two different liver enzyme-inducing agents
17. The rarity of liver toxicity in patients treated with coumarin (1,2-benzopyrone)
18. Phase II study of coumarin and cimetidine in patients with metastatic renal cell carcinoma
19. Lack of effect of coumarin on unscheduled DNA synthesis in the in vivo rat hepatocyte DNA repair assay
20. Rapid and sensitive determination of coumarin and 7-hydroxycoumarin and its glucuronide conjugate in urine and plasma by high-performance liquid chromatography
21. The pharmacology, metabolism, analysis and application of coumarin, and coumarin related compounds
22. Coumarin toxicity in different strains of mice
23. Council Directive of 22 June 1988 on the approximation of the laws of the Member States relating to flavourings for use in foodstuffs and to source materials for their production (88/388/EEC)
24. Two-year toxicity study on coumarin in the baboon
25. Studies on the induction of cholangiofibrosis by coumarin in the rat
26. Toxic hepatitis due to benzo-pyrone
27. Comparison of the effects of inducers of cytochrome P450 on Mongolian gerbil and rat hepatic microsomal monooxygenase activities
28. Metabolism of coumarin by rat, gerbil and human liver microsomes
29. Species differences in the metabolism and hepatotoxicity of coumarin
30. o-Hydroxyphenylacetaldehyde: A major novel metabolite of coumarin formed by rat, gerbil and human liver microsomes
31. Species differences in the hepatotoxicity of coumarin: A comparison of rat and Mongolian gerbil
32. A genetic polymorphism in coumarin 7-hydroxylation: Sequence of the human CYP2A genes and identification of variant CYP2A6 alleles
33. Comparison of in viva and in vitro rat hepatic toxicity of coumarin and methyl analogues, and application of quantitative morphometry to toxicity in vivo
34. Food and drugs
35. Toxicity of coumarin (1,2-benzopyrone) on human peripheral blood mononuclear cells and human and murine bone marrow progenitor stem cells
36. Studies on the metabolism and hepatotoxicity of coumarin in the baboon
37. Comparison of responses of base-specific Salmonella tester strains with the traditional strains for identifying mutagens: The results of a validation study
38. Coumarin chemoprotection against aflatoxin B1-induced gene mutation in a mammalian cell system: A species difference in mutagen activation and protection with chick embryo and rat liver S9
39. Co-mutagenicity of coumarin (1,2-benzopyrone) with aflatoxin B1 and human liver S9 in mammalian cells
40. Liver response tests. IX. Cytopathological changes in the enlarged but histologically normal rat liver
41. Pathological findings on the carcinogenic action of laboratory animals
42. Teratogenicity test of a coumarin-rutin combination by examination of fetal skeleton
43. Examination of the active substances coumarin and rutin in a teratogenic trial with rabbits
44. Test of combination of the agents coumarin and troxerutin for embryotoxic and teratogenic side-effects in Gottingen miniature pigs
45. Intraperitoneal administration of coumarin causes tissue-selective depletion of cytochromes P450 and cytotoxicity in the olfactory mucosa
46. CYP2A6 gene polymorphism and risk of liver cancer and cirrhosis
47. A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin
48. Food flavourings and compounds of related structure. II. Sobacute and chronic toxicity
49. Dose-related pharmacokinetics of coumarin, 7-hydroxycoumarin and 7-hydroxycoumarin glucuronide upon intraperitoneal administration of coumarin and 7-hydroxycoumarin in the rat
50. Salmonella mutagenicity test results for 250 chemicals
51. Toxicity of coumarin
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53. Coumarin mercapturic acid isolated from rat urine indicates metabolic formation of coumarin 3,4-epoxide
54. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man
55. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
56. 14C]coumarin by human liver microsomes
57. Interindividual variability of coumarin 7-hydroxylation in a Turkish population
58. The effects of 5,6-benzo-[a]-pyrone (coumarin) and DEC in filaritic lymphoedema and elephantiasis in India. Preliminary results
59. 14C]coumarin
60. Acute cytolytic hepatitis caused by coumarin. 2 cases
61. Investigations into the mechanism of coumarin-induced hepatotoxicity in the rat
62. Coumarin metabolism, toxicity and carcinogencity: Relevance for human risk assessment
63. Effect of pretreatment with some mixed-function oxidase enzyme inducers on the acute hepatotoxicity of coumarin in the rat
64. Comparison of the hepatotoxicity of coumarin in the rat, mouse, and Syrian hamster: A dose and time response study
65. 14C]coumarin in the rat and marmoset (Callithrix jacchus)
66. Studies on the mechanism of coumarin-induced toxicity in rat hepatocytes: Comparison with dihydrocoumarin and other coumarin metabolites
67. Studies on the hepatotoxicity and metabolism of coumarin in the rat and Syrian hamster
68. 14C]coumarin to polar and covalently bound products by hepatic microsomes from the rat, Syrian hamster, gerbil and humans
69. Identification of o-hydroxyphenylacetaldehyde as a major metabolite of coumarin in rat hepatic microsomes
70. Studies on the acute effects of coumarin and some coumarin derivatives in the rat
71. Properties of Organic Compounds
72. Effects of dietary anticarcinogens on rat gastrointestinal glutathione peroxidase activity
73. Coumarin-induced hepatotoxicity
74. Genetic variation in the metabolism of coumarin in mouse liver
75. Genetic variation between mice in their metabolism of coumarin and its derivatives
76. Coumarin in vanilla extracts: Its detection and significance
77. Treatment of metastatic renal cell carcinoma with coumarin (1,2-benzopyrone) and cimetidine: A pilot study
78. Treatment of non-small cell lung cancer with coumarin and cimetidine
79. Treatment of advanced malignant melanoma with coumarin and cimetidine: A pilot study
80. Treatment of hormone-refractory stage D carcinoma of prostate with coumarin (1,2-benzopyrone) and cimetidine: A pilot study
81. An updated review of the clinical development of coumarin (1,2-benzopyrone) and 7-hydroxycoumarin
82. Determination of 2-hydroxyphenylacetic acid (2 HPPA) in urine after oral and parenteral administration of coumarin by gas-liquid chromatography with flame-ionization detection
83. Coumarin inhibits micronuclei formation induced by benzo-[a]pyrene in male but not female ICR mice
84. Evaluation studies on the in vitro rat hepatocyte micronucleus assay
85. Mouse steroid 15α-hydroxylase gene family: Identification of type II P-450(15α) as coumarin 7-hydroxylase
86. Combined treatment of advanced malignant melanoma with coumarin and cimetidine
87. o-Hydroxyphenylethanol, a novel lactone ring-opened metabolite of coumarin
88. Anti-mutagenic effects of coumarin and umbelliferone on mutagenesis induced by 4-nitroquinoline 1-oxide or UV irradiation in E. coli
89. Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase
90. Anticoagulants
91. Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: Effects on coumarin, dicumarol, and testosterone oxidation
92. The metabolism of coumarin
93. The natural occurrence and uses of the toxic coumarins
94. Comparison of the toxicity of allyl alcohol, coumarin and menadione in precision-cut rat, guinea-pig, cynomolgus monkey and human liver slices
95. Natural ingredients based cosmetics. Content of selected fragrance sensitizers
96. Deodorants on the European market: Quantitative chemical analysis of 21 fragances
97. Metabolism and toxicity of coumarin on cultured human, rat, mouse and rabbit hepatocytes
98. Interindividual variability of coumarin 7-hydroxylation in healthy volunteers
99. Pharmacokinetics of coumarin and 7-hydroxycoumarin upon i.v. and p.o. administration in the euthyroid and hypothyroid beagle dog
100. Pharmacokinetics of coumarin, 7-hydroxycoumarin and 7-hydroxycoumarin glucuronide in the blood and brain of gerbils following intraperitoneal administration of coumarin
101. Pilot study on bioavailability of coumarin and 7-hydroxycoumarin upon peroral administration of coumarin in a sustained-release dosage form
102. Transdermal absorption and topical bioavailability of coumarin
103. Pharmacokinetics of coumarin upon i.v. administration in man
104. Pharmacokinetics of coumarin and its 7-hydroxy-metabolites upon intravenous and peroral administration of coumarin in man
105. First-pass effect of coumarin in man
106. Pharmacokinetics of coumarin and 7-hydroxycoumarin in the rhesus monkey after intravenous and peroral administration
107. Effect of coumarin (o-hydroxycinnamic acid-lactone) on pregnant female mice
108. An inhibitory monoclonal antibody to human cytochrome P450 2A6 defines its role in the metabolism of coumarin, 7-ethoxycoumarin and 4-nitroanisole in human liver
109. Inhibition of the genotoxic effects of heterocyclic amines in human derived hepatoma cells by dietary bioantimutagens
110. Studies of the role of the intestinal microflora in the metabolism of coumarin in rats
111. Metabolism of coumarin in man
112. Detection of natural bioantimutagens and their mechanisms of action with bacterial assay-system
113. Glutathione S-transferase activity: Enhancement by compounds inhibiting chemical carcinogenesis and by dietary constituents
114. Evaluation of two in vitro assays to screen for potential developmental toxicants
115. Examination of Mexican vanilla extracts for coumarin adulteration. III. Quantitative determination of coumarin
116. 14C]-7-hydroxycoumarin in the rat
117. Prevention of early recurrence of high risk malignant melanoma by coumarin
118. Non-carcinogenic response to coumarin in Syrian golden hamsters
119. 14C]coumarin in baboons
120. Antitumor-activities of coumarin, 7-hydroxycoumarin and its glucuronide in several human tumor cell lines
121. The influence of enterohepatic circulation on toxicity of drugs
122. Chemical mutagenesis testing in Drosophila. IV. Results of 45 coded compounds tested for the National Toxicology Program
123. Percutaneous absorption and metabolism of coumarin in human and rat skin
124. Biotransformation of coumarin by rodent and human cytochromes P-450: Metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice