The G20210A transition in the prothrombin gene and venous thromboembolic disease;La transition G20210A dans le gene de la prothrombine et la maladie thromboembolique veineuse

Revue de Medecine Interne

Volumn 21, Issue 10, 2000, Pages 911-914

  Trillot, N ^a   Zawadzki, C ^a   Watel, A ^a   Jude, B ^a  

^a LILLE UNIVERSITY HOSPITAL   (France)

Author keywords

FII G20210A; Inherited thrombophilia; Venous thrombosis

Indexed keywords

ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 5 LEIDEN; DNA; HEPARIN; ORAL CONTRACEPTIVE AGENT; PROTHROMBIN; RESTRICTION ENDONUCLEASE;

3' UNTRANSLATED REGION; AGE; CLINICAL FEATURE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; HETEROZYGOTE; HUMAN; POLYMERASE CHAIN REACTION; RECURRENT DISEASE; REVIEW; VEIN THROMBOSIS;

EID: 0033789041     PISSN: 02488663     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0248-8663(00)00247-2     Document Type: Article

References (15)

1. A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
2. Linkage analysis demonstrates that the prothrombin G20210A mutation jointly influences plasma prothrombin levels and risk of thrombosis
3. Geographic distribution of the 20210G to A prothrombin variant
4. The heterozygous 20210 G/A prothrombin genotype is associated with early venous thrombosis in inherited thrombophilias and is not increased in frequency in artery disease
5. The VITA Project: Prothrombin G20210A mutation and venous thromboembolism in the general population
6. Venous thromboembolic disease and the prothrombin, Methylene tetrahydrofolate reductase and factor V genes
7. The A0 allele of the prothrombin gene is frequently associated with the factor V Arg 506 to Gln mutation but not with protein S deficiency in thrombophilic families
8. Co-inheritance of the 20210A allele of the prothrombin gene increases the risk of thrombosis in subjects with familial thrombophilia
9. The risk of early recurrent venous thromboembolism after oral anticoagulant therapy in patients with the G20210A transition in the prothrombin gene
10. The risk of recurrent venous thromboembolism in carriers and non-carriers of the GI691A allele in the coaglualation factor V gene and the G20210A allele in the prothrombin gene
11. The risk of recurrent deep venous thrombosis among heterozygous carriers of both factor V Leiden and the G20210A prothrombin mutation
12. Coexistence of factor V Leiden and factor II A20210 mutations and recurrent venous thromboembolism
13. Clinical studies and thrombin generation in patients homozygous or heterozygous for the G20210A mutation in the prothrombin gene
14. Homozygous G20210A transition in the prothrombin gene associated with severe thrombotic disease: Two cases in a French family
15. A comparison of six weeks with six months of oral anticoagulant therapy after a first episode of venous thromboembolism