Synthesis and HIV protease inhibitory activity of new 4-hydroxy-2-pyrone derivatives

Archiv der Pharmazie

Volumn 333, Issue 10, 2000, Pages 319-322

  Lee, Yong Sup ^a   Kim, Sun Nam ^a   Lee, Yong Sil ^a   Lee, Jae Yeol ^a   Lee, Chong Kyo ^b   Kim, Hae Soo ^b   Park, Hokoon ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

4 hydroxy 2 pyrone; HIV; Nonpeptide; Protease inhibitors; Sulfonamide

Indexed keywords

2 PYRONE DERIVATIVE; 4 CYANO N [3 [(CYCLOPROPYL)(5,6,7,8,9,10 HEXAHYDRO 4 HYDROXY 2 OXO 2H CYCLOOCTA[B]PYRAN 3 YL)METHYL]PHENYL]BENZENESULFONAMIDE; 4 HYDROXY 2 PYRONE; PNU 96988; PROTEINASE INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIVIRAL ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LETTER; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

HIV PROTEASE INHIBITORS; PYRONES; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T;

EID: 0033788780     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4184(200010)333:10<319::AID-ARDP319>3.0.CO;2-A     Document Type: Letter

References (15)

1. Obstacles to Drug Development from Peptide Leads