Enhancement of 2'-deoxyguanosine hydroxylation and DNA damage by coal and oil fly ash in relation to particulate metal content and availability

Chemical Research in Toxicology

Volumn 13, Issue 10, 2000, Pages 1011-1019

  Prahalad, A K ^a   Inmon, J ^b   Ghio, A J ^b   Gallagher, J E ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM; CHELATE; COAL; DEFEROXAMINE; DEOXYGUANOSINE; DNA; FERROZINE; IRON; IRON OXIDE; METAL DERIVATIVE; NICKEL; OIL; SILICATE; VANADIUM;

ARTICLE; CATALYSIS; CHEMICAL COMPOSITION; CHEMICAL REACTION KINETICS; CONCENTRATION RESPONSE; DNA DAMAGE; FLY ASH; HYDROXYLATION; PARTICULATE MATTER; SOLUBILITY;

ANIMALS; CARBON; CATALYSIS; CATTLE; CHELATING AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COAL; DEOXYGUANOSINE; DIMETHYL SULFOXIDE; DNA DAMAGE; HYDROXYLATION; INDICATORS AND REAGENTS; INDUSTRIAL WASTE; METALS; OXIDATION-REDUCTION; PARTICULATE MATTER; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0033787675     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx000110j     Document Type: Article

References (49)

1. Urban air quality and chronic respiratory disease
2. An association between air pollution and mortality in six U.S. cities
3. Air pollution and daily mortality: A review and meta analysis
4. Health effects of particulate air pollution: Time for reassessment?
5. Toxicological evidence for health effects from inhaled particulate pollution: Does it support the human experience?
6. Humic-like substances in air pollution particulates correlate with concentrations of transition metals and oxidant generation
7. In vivo evidence of free radical formation in the rat lung after exposure to an emission source air pollution particles
8. Genotoxicity of active oxygen species in mammalian cells
9. Oxidative mechanisms in the toxicity of metal ions
10. Oxidant generation and lung injury after particulate air pollutant exposure increase with the concentrations of the associated metals
11. On the relations between atmospheric pollution in urban and rural localities and mortality from cancer, bronchitis, pneumonia, with particular reference to 3,4-benzopyrene, beryllium, molybdenum, vanadium and arsenic
12. Quantitation of manganese and vanadium levels in the lungs of normal and occupationally exposed persons
13. Mutagenicity, carcinogenicity and teratogenicity of vanadium compounds
14. Vanadyl(IV) and vanadate(V) binding to selected endogenous phosphate, carboxyl, and amino ligands; calculations of cellular vanadium species distribution
15. The role of oxidative damage in metal carcinogenicity
16. Toxicity and carcinogenicity of nickel compounds
17. Decline in the lung cancer hazard: A prospective study of the mortality of iron ore miners in Cumbria
18. Cancer of the lung in iron ore miners
19. Vanadyl-induced Fenton-like reaction in RNA an ESR and spin trapping study
20. Ambient air particles: Effects on cellular oxidant generation in relation to particulate elemental chemistry
21. Luminol-enhanced chemiluminescence induced in peripheral blood-derived human phagocytes: Obligatory requirement of myeloperoxidase exocytosis by monocytes
22. DNA damage caused by oxidation, deamination, ultraviolet radiation and photoexcited psoralens
23. Metal-catalyzed oxidative degradation of DNA: Base damage and mechanistic aspects
24. Hydroxylation of deoxyguanosine at the C-8 position by ascerbic acid and other reducing agents
25. Oxidative DNA and RNA damage in the livers of Sprague-Dawley rats treated with the hepatecarcinogen 2-nitropropane
26. A procedure for the isolation of deoxyribonucleic acid from micro-organisms
27. Improvements in the analytical method for 8-hydroxydeoxyguanosine in nuclear DNA
28. Vanadium(IV)-mediated free radical generation and related 2'-deoxyguanosine hydroxylation and DNA damage
29. Enhancement of hydroxylation and deglycosylation of 2'-deoxyguanosine by carcinogenic nickel compounds
30. Properties of ambient PM responsible for human health effects: Coherence between epidemiology and toxicology
31. Radical oxidation reactions of the purine moiety of 2'-deoxyribonucleosides and DNA by iron-containing minerals
32. The effect of chelating agents on vanadium distribution in the rat body and on uptake by human erythrocytes
33. Chelates antidotes for sodium vanadate and vanadyl sulfate intoxication in mice
34. Protection of mice against the lethal effects of sodium metavanadate: A quantitative comparison of a number of chelating agents
35. -
36. Luminol-enhanced chemiluminescence after in vitro exposures of rat alveolar macrophages to oil fly ash is metal dependent
37. Antioxidant and free radical scavenging activities of the iron chelators pyoverdin and hydroxypyrid-4-ones in iron-loaded hepatocyte cultures: Comparison of their mechanism of protection with that of desferrioxamine
38. DNA damage induced by asbestos in the presence of hydrogen peroxide
39. Hydroxyl free radical mediated formation of 8-hydroxyguanosine in isolated DNA
40. Mutagenesis by the autoxidation of iron with isolated DNA
41. The structure and reaction processes of coal
42. Concentrations of metal elements in mouse lung after intratracheal administration of coal fly ash
43. Iron mobilization from crocidolite asbestos greatly enhances crocidolite-dependent formation of DNA single-strand breaks in φX174 RFI DNA
44. Mobilization of iron from coal fly ash was dependent upon the particle size and the source of coal
45. One-electron reduction of vanadate by ascorbate and related free radical generation at physiological pH
46. Mechanism of DNA oxidation
47. Iron-catalyzed hydroxyl radical formation
48. Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues
49. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G→T and A→C substitutions