S-adenosylmethionine prevents hepatic tocopherol depletion in carbon tetrachloride-injured rats

Clinical Science

Volumn 99, Issue 4, 2000, Pages 315-320

  Deulofeu, R ^a   Pares, A ^a   Rubio, M ^a   Gasso, M ^a   Roman, J ^a   Gimenez, A ^a   Varela Moreiras, G ^a   Caballeria, J ^a   Ballesta, A M ^a   Mato, J M ^a   Rodes, J ^a  

^a HOSPITAL CLÍNIC   (Spain)

Author keywords

Ascorbic acid; CCl4; Glutathione; Lipid peroxidation; Vitamin C; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; CARBON TETRACHLORIDE; COLLAGEN; GLUTATHIONE; HYDROXYPROLINE; S ADENOSYLMETHIONINE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ALPHA TOCOPHEROL DEFICIENCY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; LIVER CIRRHOSIS; LIVER INJURY; MALE; MEASUREMENT; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

EID: 0033787377     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0990315     Document Type: Article

References (45)

1. Regulation of phospholipid methylation and its effect on membrane protein
2. Transmethylation, transsulphuration and aminopropylation reactions of S-adenosyl-L-methionine in vivo
3. S-adenosyl-L-methionine: A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism
4. S-adenosyl-L-methionine attenuates alcohol-induced liver injury in the baboon
5. Protective role of s-adenosyl-L-methionine on liver injury induced by d-galactosamine in rats
6. The pathophysiological significance of lipid peroxidation in oxidative cell injury
7. S-adenosyl-L-methionine prevents intracellular glutathione depletion by GSH-depleting drugs in rat and human hepatocytes
8. Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver diseases
9. Oral S-adenosyl-L-methionine in the symptomatic treatment of intrahepatic cholestasis: A double blind, placebo-controlled study
10. S-adenosyl-L-methionine in the treatment of patients with intrahepatic cholestasis of pregnancy: A randomized, double blind placebo-controlled study with negative results
11. S-adenosylmethionine in the treatment of alcoholic liver cirrhosis: Results from a multicentric, placebo-controlled, randomized, double-blind clinical trial
12. Lipoperoxidation as a vector in carbon tetrachloride hepatotoxicity
13. Carbon tetrachloride hepatotoxicity: An example of lethal cleavage
14. Depressed selenium and vitamin E levels in alcoholic population: Possible relationships to hepatic injury through increased lipid peroxidation
15. Effect of heavy alcohol consumption on serum concentration of fat soluble vitamins and selenium
16. Reduced concentration of hepatic α-tocopherol in patients with alcoholic liver cirrhosis
17. Differential depletion of carotenoids and tocopherol in liver disease
18. Vitamin E deficiency in adults with chronic liver disease
19. Vitamin E dietary supplementation protects against carbon tetrachloride-induced chronic liver damage and cirrhosis
20. Ascorbate: The most effective antioxidant in blood plasma
21. Cellular defenses against damage from reactive oxygen species
22. The antioxidant role of vitamin C
23. Glutathione deficiency decreases tissue ascorbate levels in newborn rats: Ascorbate spares glutathione and protects
24. Vitamins: Vitamin E
25. Measurements of total ascorbic acid in biological fluids
26. A fluorimetric method for determination of oxidized and reduced glutathione in tissues
27. Determination of malonaldehyde in biological materials by high-pressure liquid chromatography
28. Amino acid analysis by reverse phase High-Performance Liquid Chromatography: Precolumn derivatization with phenylisothiocyanate
29. S-adenosylmethionine treatment prevents carbon tetrachloride induced S-adenosylmethionine synthetase inactivation and attenuates liver injury
30. Effects of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis
31. α-Tocopherol inhibits collagen alpha (1) gene expression in cultured human fibroblasts: Modulation of constitutive gene expression by lipid peroxidation
32. Depressed hepatic glutathione and increased diene conjugates in alcoholic liver disease. Evidence of lipid peroxidation
33. Ascorbic acid deficiency in liver disease
34. Ascorbic acid deficiency in porphyria cutanea tarda
35. Oxidative stress in patients with hepatitis, cirrhosis, and hepatoma evaluated by plasma antioxidants
36. Lipid peroxidation and antioxidant systems in the liver injury produced by glutathione depleting agents
37. Effects of alpha-tocopherol on carbon tetrachloride metabolism in rat liver microsomes
38. Vitamin E in humans: Demand and delivery
39. Absorption, transport and metabolism of vitamin E
40. Oxygen toxicity: Unique cytoprotective properties of vitamin E succinate in hepatocytes
41. Prevention of hepatocyte injury and lipid peroxidation by iron chelators and alpha-tocopherol in isolated iron-loaded hepatocytes
42. Comparative evaluation of the antioxidant activity of alpha-tocopherol, alpha-tocopherol polyethylene glycol 1000 succinate and alpha-tocopherol succinate in isolated hepatocytes and liver microsomal suspensions
43. Antioxidant defense systems and oxidative stress
44. Safety of high levels of vitamin C ingestion
45. Renal metabolism of the oxidized form of ascorbic acid (dehydro-L-ascorbic acid)