Molecular composition and function of the slit diaphragm: Nephrin, the molecule responsible for proteinuria

Clinical and Experimental Nephrology

Volumn 4, Issue 3, 2000, Pages 161-172

  Kawachi, Hiroshi ^a   Shimizu, Fujio ^a  

^a NIIGATA UNIVERSITY   (Japan)

Author keywords

Barrier function; Nephrin; Podocyte; Proteinuria; Slit diaphragm; ZO 1

Indexed keywords

CADHERIN; FAT PROTEIN; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 5 1 6; NEPHRIN; P CADHERIN; PLASMA PROTEIN; PROTEIN ZO1; UNCLASSIFIED DRUG;

GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS CAPILLARY; GLOMERULUS FILTRATION; HUMAN; NONHUMAN; PATHOGENESIS; PODOCYTE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTEINURIA; REVIEW; STRUCTURE ANALYSIS; TIGHT JUNCTION;

EID: 0033786902     PISSN: 13421751     EISSN: None     Source Type: Journal    
DOI: 10.1007/s101570070017     Document Type: Review

References (87)

1. A scanning electron microscopy of the glomerulus of normal and nephrotic rats
2. A scanning electron microscopy of human glomerulus
3. The fine structure of the renal glomerulus of the mouse
4. Glomerular permeability I. Ferritin transfer across the normal glomerular capillary wall
5. Porous substructure of the glomerular slit diaphragm in the rat and mouse
6. Massive proteinuria induced in rats by a single intravenous injection of a monoclonal antibody
7. Positionally cloned gene for a novel glomerular protein - nephrin - Is mutated in congenital nephrotic syndrome
8. Nephrin is specifically located at the site of the slit diaphragm of glomerular podocytes
9. Cloning and expression of the rat nephrin homologue
10. Cloning of rat nephrin: Expression in developing glomeruli and in proteinuric states
11. Glomerular expression of nephrin is decreased in acquired human nephrotic syndrome
12. Endothelial cell membrane contains podocalyxin - The major sialoprotein of visceral glomerular epithelial cell
13. The ultrastructure of the normal human glomerulus
14. Morphometric studies of the peripheral glomerular basement membrane in early juvenile diabetes: Development of initial basement membrane thickening
15. Quantitative glomerular morphology of the normal human kidney
16. Thickness of glomerular basement membranes
17. Structure and development of the glomerular capillary wall and basement membrane
18. Alport syndrome and thin basement membrane disease
19. Isolation of the specific glomerular basement membrane antigen involved in Goodpasture syndrome
20. Goodpasture antigen of the glomerular basement membrane: Localization of noncollagenous region of type IV collagen
21. Physical and immunochemical studies of the glomerular domain of type IV collagen
22. Alport familial nephritis: Absence of 28 kilodalton noncollagenous monomer of type IV collagen in glomerular basement membrane
23. Distribution of anionic sites in glomerular basement membranes: Their possible role in filtration and attachment
24. Presence of heparan sulfate in the glomerular basement membrane
25. Isolation of glycosaminoglycans (heparan sulfate) from glomerular basement membranes
26. Glomerular permeability: In vivo tracer studies with polyanionic and polycationic ferritins
27. Glomerular filtration of proteins: Clearance of anionic, neutral and cationic horseradish peroxidase in the rat
28. The permeability of glomerular capillaries to graded dextrans. Identification of the basement membrane as the primary filtration barrier
29. Glomerular permeability: Ultrastructural cytochemical studies using peroxidases as protein tracers
30. Bovine lactoperoxidase as a cytochemical protein tracer for electronmicroscopy
31. Protein transfer in mouse kidney utilizing tyrosinase as an ultrastructural tracer
32. The isoporous substructure of the human glomerular slit diaphragm
33. Identification and characterization of podocalyxin - The major sialoprotein of the renal glomerular epithelial cell
34. Glomerular permeability barrier in the rat. Functional assessment by in vivo methods
35. Structural determinants of glomerular hydraulic permeability
36. Hindered transport of macromolecules through a single row of cylinders: Application to glomerular filtration
37. Hindered transport of macromolecules in isolated glomeruli. II. Convection and pressure effects in basement membrane
38. Ultrastructural model for size selectivity in glomerular filtration
39. The tight junction protein ZO-1 is concentrated along slit diaphragm of the glomerular epithelium
40. Slit diaphragm-reactive nephritogenic MAb 5-1-6 alters expression of ZO-1 in rat podocytes
41. Nephritogenic mAb 5-1-6 is directed at the extracellular domain of rat nephrin
42. Unraveling the mechanisms of glomerular ultrafiltration: Nephrin, a key component of the slit diaphragm
43. The glomerular slit diaphragm is a modified adherens junction
44. FAT is a possible component of the slit diaphragm
45. Differentiation of epithelial foot processes and filtration slits: Sequential appearance of occluding junctions, epithelial polyanion, and slit membrane in developing glomeruli
46. Biogenesis of podocalyxin: The major glomerular sialoglycoprotein in the new born rat kidney
47. Identification of ZO-1: A high molecular weight polypeptide associated with the tight junction (zonnula occludens) in a variety of epithelia
48. Developmental expression of the nephritogenic antigen of monoclonal antibody 5-1-6
49. Symplekin a novel type of tight junction plaque protein
50. Mammalian occludin in epithelial cells: Its expression and subcellular distribution
51. The 220kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction associated protein in epithelial cells: cDNA cloning and immunoelectronmicroscopy
52. Cell adhesion: The molecular basis of tissue architecture and morphogenesis
53. Nephrin localizes to the slit pore of the glomerular epithelial cell
54. Nephrin localizes at the podocyte filtration slit area and is characteristically spliced in the human kidney
55. Cloning of murine nephrin and comparison to the human NPHS1 gene
56. Congenital nephrotic syndrome in mice lacking CD2-associated protein
57. A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts
58. Quantitative studies of monoclonal antibody 5-1-6-induced proteinuric state in rats
59. Effect of chlorpromazine on kinetics of injected monoclonal antibody in MoAb-induced glomerular injury
60. Divalency of the monoclonal antibody 5-1-6 is required for induction of proteinuria in rats
61. Strain variation in susceptibility to the development of monoclonal antibody 5-1-6-induced proteinuria in rats
62. Water and protein permeability is regulated by the glomerular epithelial slit diaphragm
63. Altered anionic GBM components in monoclonal antibody against slit diaphragm-injected proteinuric rats
64. Altered localization of antigen recognized by proteinuria-inducing monoclonal antibody in experimental nephrosis
65. Study on the glomerular alterations in the proteinuric rats induced by a monoclonal antibody 5-1-6
66. New concepts of glomerular injury: Role of an epitope specific interaction
67. Structural continuity of filtration slit (slit diaphragm) to plasma membrane of podocyte
68. Podocytes in metanephric organ culture express characteristic in vivo phenotypes
69. Characterization of ZO-1, a protein component of the tight junction from mouse liver and Madin-Darby canine kidney cells
70. Protein-protein interaction: PDZ domain networks
71. Protein interactions in the tight junction: The role of MAGUK proteins in regulating tight junction organization and function
72. The tight junction protein ZO-1 establishes a functional link between occludin and actin cytoskeleton
73. Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and drosophilia discs-large tumor suppressor protein
74. Localization and differential expression of two isoforms of the tight junction protein ZO-1
75. Diversity among tight junctions in rat kidney: Glomerular slit diaphragms and endothelial junctions express only one isoform of the tight junction protein ZO-1
76. The altered glomerular filtration slits seen in puromycin aminonu-cleotide nephrosis and protamine sulfate-treated rat contain the tight junction protein ZO-1
77. Increased Tyr phosphorylation of ZO-1 during modification of tight junction between glomerular foot processes
78. Effect of angiotensin-converting enzyme inhibition on glomerular basement membrane permeability and distribution of zonnula occludens-1 in MWF rats
79. Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions
80. Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins
81. Involvement of R-cadherin in the early stage of glomerulogenesis
82. Morphogenic roles of classic cadherins
83. Protocadherins and diversity of the cadherin superfamily
84. Urinary excretion of podocalyxin indicates glomerular epithelial cell injuries in glomerulonephritis
85. Urinary excretion of podocytes reflects disease activity in children with glomerulonephritis
86. Loosening tight junctions: Lessons from the intestine
87. First components found for key kidney filter (News Focus)